Ask about this productRelated genes to: SHBG protein
- Gene:
- SHBG NIH gene
- Name:
- sex hormone binding globulin
- Previous symbol:
- -
- Synonyms:
- ABP, TEBG, MGC126834, MGC138391
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-14
- Date modifiied:
- 2016-04-04
Related products to: SHBG protein
Related articles to: SHBG protein
- Free testosterone (FT), the bioactive form comprising 1%-2% of total testosterone, directly enters cells. Unlike total testosterone, FT levels are less affected by sex hormone-binding globulin and better reflect biological activity. Accurate serum FT measurement is crucial for diagnosing conditions like male hypogonadism, PCOS, metabolic syndrome, osteoporosis, and Alzheimer's. However, existing methods suffer from inadequate sensitivity, complexity, and high cost, necessitating improved detection technologies. We developed and evaluated a chemiluminescence assay kit for FT. - Source: PubMed
Publication date: 2026/04/28
Han ShuangLiu MinZhao SiminYan WenjunLu ZhixianHuang Xuan - β-Glucan, which is a type of polysaccharide, provides both cytoprotective effects and immunomodulatory effects, which scientists can use to develop treatments for hematologic conditions and melanoma through their ability to regulate lipid-hormone pathways. This study develops a computational framework to validate its effectiveness by combining network pharmacology and docking and Molecular Dynamics (MD) and In-vitro studies and experimental proof to study the immunomodulatory effects and antimelanoma Lipid-Hormone Axis modulation effects and Erythroprotection capabilities of β-Glucan obtained from Plum (Prunus bokharensis) PLYE1 through its extraction and characterization. β-Glucan extracted (NaOH/NaClO, 3.2 gms ± % yield) and characterized (HRMS: DP 1-5, β-(1 → 3)/(1 → 6) linkages). Network analysis using TCMSP and DisGeNET together with network analysis methods identified 110 compounds and 204 melanoma genes as research targets while they classified β-Glucan with a perfect score of 100 and identified NPC1L1 and HMGCR and NR1H3 and ESR2 and SHBG as essential network elements. Docking displayed high-resolution parameters between 2.00 and 3.3 Å together with high stereochemical accuracy enabled target protein assessment. Ramachandran plot analysis addressed ligand bound structures maintained their biological integrity which enabled accurate evaluation of β-Glucan therapeutic potential. The 500 ns MD simulation of the 7N4X-β-Glucan complex demonstrated binding stability through RMSD measurements which disclosed that the system reached equilibrium between 200 and 250 ns and maintained a stable distance range of 4.5 to 5.5 Å. The RMSF results showed that most residues displayed minor fluctuations beneath 1.5 Å while loop areas experienced greater movement that reached 3 to 6 Å. The radius of gyration remained stable at 4.3 to 5.0 Å which demonstrated that the protein maintained its compact structure while continuing to interact with ligands. The in-vitro study demonstrates that β-Glucan functions as an external ligand which triggers receptor-based immune response activation together with an increase in phagocytosis of 72.14% and an induction of cell death at an IC50 value of 104.33 μg/mL which caused BAX to increase and BCL2 to decrease but maintained Caspase-3 at its normal level. The docking results together with the 500 ns MD stability tests provide evidence that Prunus bokharensis (PLYE1) derived β-Glucan maintains its stable structural properties while interacting consistently with its key target molecules. The study demonstrated that the substance regulates lipid-hormone activity and offers therapeutic benefits through its immunomodulatory effects which occur via receptor pathways and its ability to induce apoptosis, thus establishing its value as a versatile bioactive molecule. - Source: PubMed
Publication date: 2026/04/28
Chaudhari ShradhaGaikwad ShikhaPolshettiwar Satish - Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder in which hyperandrogenism represents a centralpathophysiological feature. Increasing attention has been directed toward chronic inflammatory factors that may modulate androgenexcess. Helicobacter pylori (H. pylori) infection is a prevalent chronic bacterial infection associated with systemic low-grade inflammation.However, its potential relationship with androgen-related hormonal parameters in PCOS remains poorly explored. - Source: PubMed
Wutke-Ostręga JoannaSzul MateuszPluta Dagmara - Low circulating testosterone in physically stressed populations is frequently interpreted as evidence of hypogonadism or intrinsic gonadal dysfunction. However, convergent data from military field studies, endurance athletes, and competitive stress models demonstrate that testosterone suppression during sustained stress is commonly a centrally mediated, reversible adaptation rather than intrinsic testicular failure. Severe energy deficit, sleep disruption, and uncontrollable psychogenic stress suppress hypothalamic gonadotropin-releasing hormone and luteinizing hormone pulsatility, reduce testicular androgen production, and frequently increase sex hormone-binding globulin (SHBG), thereby disproportionately lowering free testosterone. Human chorionic gonadotropin stimulation studies confirm preserved Leydig cell responsiveness under these conditions, supporting hypothalamic-pituitary inhibition as the dominant mechanism. In contrast, high mechanical loading in resistance-trained men does not suppress basal testosterone when energy availability is maintained, underscoring energetic sufficiency, not exercise modality, as the principal determinant of androgen tone. Acute competitive stress produces rapid, appraisal-dependent modulation of testosterone independent of SHBG, further demonstrating central regulation. Across contexts, androgen suppression tracks energetic and psychological constraint and is reversible with restoration of energy balance and recovery. Recognition of this adaptive endocrine phenotype is essential to distinguish functional central suppression from pathological hypogonadism and to guide appropriate clinical evaluation. - Source: PubMed
Publication date: 2026/04/27
Friedl Karl ENindl Bradley CPotter Adam W - This study reviews the main candidate genes involved in the pathophysiology of Polycystic Ovary Syndrome (PCOS). PCOS is a common endocrine-metabolic disorder in women of reproductive age, characterized by menstrual irregularity, hyperandrogenism, and polycystic ovarian morphology. It is associated with increased metabolic and cardiovascular risk and is a leading cause of infertility. Although its pathophysiology is not fully understood, alterations in the hypothalamic-pituitary-ovarian axis, insulin metabolism, and steroidogenesis have been described. Polymorphisms in genes encoding hormones, enzymes, and receptors in these pathways contribute to clinical variability and ethnic differences, offering potential for early diagnosis and personalized medicine. This review summarizes key candidate genes related to insulin metabolism (INS, INSR, IRS-1), the hypothalamic-pituitary-ovarian axis (LHβ, LHCGR, FSHR, GnRHR, AMH, AMHR2, KISS1, CAPN10), steroidogenesis (CYP11A, CYP17A1, CYP19A1, CYP21, 17β-HSD, SHBG, AR, STAR), and other clinically relevant mechanisms such as obesity, lipid metabolism (PPARG, VDR, FTO), and follicular development (ACE). - Source: PubMed
Publication date: 2026/04/19
Cepero-González María de Los AngelesAguilar-Galarza AdrianaRodríguez-García Víctor ManuelGarcía-Gasca TeresaMoreno Celis Ulisses