Ask about this productRelated genes to: CD138 antibody
- Gene:
- SDC1 NIH gene
- Name:
- syndecan 1
- Previous symbol:
- SDC
- Synonyms:
- CD138, syndecan, SYND1
- Chromosome:
- 2p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-03-18
- Date modifiied:
- 2014-11-19
Related products to: CD138 antibody
Related articles to: CD138 antibody
- Breast cancer (BC) incidence continues to rise, and recurrence and metastasis remain major contributors to mortality. The epithelial-mesenchymal transition (EMT), associated with the acquisition of invasive functions by epithelial cells, also promotes resistance to anticancer therapies. Here, an EMT-based prognostic model was developed to enhance BC outcome prediction. - Source: PubMed
Publication date: 2026/03/15
Wu ZizhengZheng JieMen ShuaiSui ShuangruiYan WeitaoLiu YinfengHan Meng - Shedding of the proteoglycan syndecan-1 (SDC-1) from the vascular endothelial surface into the circulation in severe trauma predicts mortality in trauma patients. However, the timing and duration of SDC-1 elevation in trauma patients have not been defined. The primary aim of this study was to describe the longitudinal pattern of SDC-1 elevation in trauma patients with either mechanical and/or burn injury during the first 120 hours of resuscitation and initial stabilization. Our secondary objective was to determine the association of endotheliopathy, as defined by elevated SDC-1 levels, with trauma-induced coagulopathy (international normalized ratio [INR] ≥ 1.4). - Source: PubMed
Publication date: 2026/04/07
Bonson GraceCallas PeterBravo Maria-CristinaOrfeo ThomasSackheim AdrianFauver OliviaWager Ray Abigail BKing RozCallcut Rachael APusateri Anthony EShupp Jeffrey WCohen Mitchell JFreeman Kalev - Acute respiratory distress syndrome (ARDS) has a high clinical mortality rate and continues to draw research attention regarding its mechanisms and potential treatments. Disruption of the endothelial barrier is a primary pathological feature, and glycocalyx degradation is a key factor contributing to this disruption. Human umbilical cord mesenchymal stem cells (hucMSCs) exhibit strong anti-inflammatory and immunomodulatory effects, making their application in ARDS treatment an area of increasing interest. Proteomic screening identified Cxcl12 as a protein secreted by hucMSCs. In male C57 mice and cell models, lipopolysaccharide (LPS) was used to induce injury, followed by interventions with hucMSCs or hucMSCs with silenced Cxcl12 to assess glycocalyx-related proteins SDC-1, HS, and the repair marker EXT-1. To evaluate downstream signaling, the CXCR4 receptor was inhibited and related indicators were examined. Silencing Cxcl12 reduced the therapeutic effect of hucMSCs on LPS-induced glycocalyx damage. Inhibition of CXCR4 also weakened the effect of Cxcl12. These findings indicate that hucMSCs alleviate LPS-induced glycocalyx damage in pulmonary vascular endothelial cells by secreting Cxcl12, which activates the downstream receptor CXCR4, providing a therapeutic effect for ARDS. - Source: PubMed
Publication date: 2026/04/16
Cui JinfengPeng ZhenyiChen YuanyuanLiu WeiChen QiuwenWang XiaozhiWang TaoHuang XiaoSun Ting - Peritoneal fibrosis (PF) is a serious complication in patients undergoing peritoneal dialysis (PD). Heparanase (HPA) may drive the progression of PF by promoting inflammation and tissue remodeling. This study aimed to evaluate HPA expression in peritoneal dialysate from end-stage renal disease (ESRD) patients receiving PD and to assess the correlation between HPA and fibrosis markers in PF. Peritoneal dialysate samples from ESRD patients were collected to measure HPA, syndecan-1 (SDC-1), and fibrosis markers. To further investigate the regulatory role of HPA in PF, a mouse model was established. Then mice were divided into four groups (n = 6 per group): control, PF, PF + HPSEi, and PF + Bailing groups. Tissue samples were collected for the detection of HPA, SDC-1, and fibrosis markers using RT-qPCR and Western blot. Fibrosis was evaluated via H&E and Masson staining. In peritoneal dialysate from 104 participants, HPA levels were positively correlated with SDC-1 (r = 0.617), TGF-β (r = 0.413), fibronectin (r = 0.278), and collagen I (r = 0.276). HPA (β = 0.0024), SDC-1 (β = 0.0572), TGF-β (β = 0.4358), and collagen I (β = 0.0023) were positively correlated with dialysis duration (all p < 0.05). Additionally, HPA was associated with high peritoneal transport function (p = 0.043). In mouse tissues, HPA inhibitor treatment downregulated TGF-β1, α-SMA, collagen I, and SDC-1, while upregulated E-cadherin expression and reducing tissue fibrosis. These effects were similar to those observed in the Bailing treatment group (all p < 0.05). HPA is positively correlated with SDC-1 and fibrosis markers. Inhibition of HPA attenuates PF, potentially through the HPA/SDC-1/TGF-β axis. - Source: PubMed
Wang JinLiu LipingHuang ShitaoHuang ZhongyaSun YiboYu YangZhao XueZeng Xiuqin - This randomized, double-blind, placebo-controlled trial investigated the effects of extract (CLE) supplementation on vascular, redox-inflammatory biomarkers, and neuropathy symptoms in adults with type 2 diabetes mellitus (T2DM). - Source: PubMed
Publication date: 2026/04/15
Viudes Drielly RodriguesMateus Alanna RamalhoSilva Cristina Antonialido Carmo Franco Maria