Ask about this productRelated genes to: MAdCAM1 antibody
- Gene:
- MADCAM1 NIH gene
- Name:
- mucosal vascular addressin cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- MACAM1
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-11
- Date modifiied:
- 2014-11-19
Related products to: MAdCAM1 antibody
Related articles to: MAdCAM1 antibody
- The rumen epithelium of Tibetan sheep plays a critical role in energy metabolism and immune defense; however, its post-transcriptional regulatory mechanisms under high-altitude hypoxia stress remain unclear. In this study, we employed integrated mRNA and miRNA transcriptome sequencing to analyze the adaptive strategies of the rumen epithelium in Tibetan sheep at different altitudes. A total of 2183 differentially expressed genes (DEGs) and 135 differentially expressed miRNAs (DEmiRNAs) were identified. Functional enrichment analysis revealed that DEGs and their target genes were significantly enriched in immune-related pathways such as the NF-κB signaling pathway and cytokine-cytokine receptor interaction, as well as metabolic pathways including oxidative phosphorylation and branched-chain amino acid degradation. Integrated network analysis highlighted key regulatory pairs, including targeting and , and regulating , suggesting coordinated modulation between mitochondrial homeostasis and immune responses. Specifically, the upregulation of immune genes (, ) and heat shock proteins at TS4500m indicates enhanced mucosal immunity and stress tolerance, while altered expression of metabolic genes reflects a shift in energy substrate utilization. These findings elucidate a complex mRNA-miRNA regulatory network that enables Tibetan sheep to maintain rumen epithelial integrity and energy balance under extreme high-altitude conditions, providing novel insights into the molecular basis of hypoxia adaptation in ruminants. - Source: PubMed
Publication date: 2026/05/28
Wang LeiHuang WeiSha YuzhuHe YanyuShao PengyangChen QianlingHe YapengFan JiangfengLiu XiuDu Wenhui - Given the global issue of the rising incidence of early-onset colorectal cancer (CRC), we tested the hypothesis that tumor vasculature phenotypes might vary with age at CRC diagnosis. - Source: PubMed
Publication date: 2026/03/25
Matsuda KosukeUgai SatokoMiyahara SatoshiYao QianCazaubiel JulesNakazawa NobuhiroHigashioka MayuZhong YuxueChan Andrew TMeyerhardt Jeffrey ANg KimmieSong MingyangVäyrynen Juha PNowak Jonathan AGiannakis MariosUgai TomotakaOgino Shuji - Tissue resident memory CD4+ T cells (TRMs) populate mucosal sites and play a critical role in local immune responses. Gut TRM cells persist for extended periods in the gut mucosa where they rapidly respond to invading pathogens and provide long lasting protection. This study investigates the factors that mediate differentiation of naïve CD4+ T cells into cells presenting a gut TRM phenotype. Naïve CD4+ T cells were cultured under conditions that mimicked mucosal environments. This included signaling through MAdCAM-1 in the presence of Retinoic Acid (RA) and TGF-β. This combination of stimuli primed naïve CD4+ T cells to adopt a TRM phenotype. However, to fully differentiate into TRMs an additional soluble factor provided by memory T cells was required. Our results identified IL-6 as one of the key factors that induces the expression of TRM -associated markers, including CD69, CD103 and CCR5. This unique combination of stimuli promoted TRM differentiation despite low level proliferation. TRM differentiation was mediated through JAK/STAT signaling, and antagonists that target JAK/STAT pathways suppressed MAdCAM-1 mediated TRM cell formation. Our findings revealed that MAdCAM-1 works together with TGF-β, RA and IL-6 in this process. Such information may aid in the design of next generation adjuvants and effective mucosal vaccines. Additionally, each of these factors may be targeted to treat excessive gut inflammation associated with conditions like inflammatory bowel disease. Overall, these findings provide new strategies aimed at modulating immune responses to invading pathogens and identify therapeutic approaches toward regulating gut inflammation. - Source: PubMed
Publication date: 2026/03/16
Kim Han GChan AmandaVimopatranon SinmanusGirard AlexandreJiang AndrewWertz SamuelHwang Il-YoungKehrl John HSchmeisser HanaSeemiller Madelyn MLusso PaoloHuang DaweiWei DanlanGoes Livia RSoares MarceloMartinelli ElenaArthos JamesCicala Claudia - - Source: PubMed
Publication date: 2026/02/26
Li YuananLiu YifanLu BingnanYao YuntaoLyu DonghaoZhang HangbiaoCui XingangPan Xiuwu - Enhanced expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) on high endothelial venules facilitates lymphocyte migration to sites of intestinal inflammation in inflammatory bowel disease (IBD). This process may be accompanied by increased shedding of soluble MAdCAM-1 (sMAdCAM-1) from endothelial cells. Hence, circulating sMAdCAM-1 may serve as a biomarker of intestinal inflammation in IBD. - Source: PubMed
Publication date: 2026/02/24
Muschaweck MoritzGutbier ChristianSellge GernotPappa AngelikiWenzl TobiasHamesch KarimWagner NorbertSchippers Angela