CD49b antibody (Azide Free)
- Known as:
- CD49b (anti-) (Azide Free)
- Catalog number:
- 10r-cd49cmsp
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- CD49b antibody (Azide Free)
Related genes to: CD49b antibody (Azide Free)
- Gene:
- ITGA2 NIH gene
- Name:
- integrin subunit alpha 2
- Previous symbol:
- CD49B
- Synonyms:
- CD49b
- Chromosome:
- 5q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2019-04-23
Related products to: CD49b antibody (Azide Free)
Related articles to: CD49b antibody (Azide Free)
- Compared with transplanted tumors, autochthonous tumors are difficult to cure using experimental radiation therapy in mice. Here we analyzed differences in immune-related gene expression profiles between mouse fibrosarcomas subcutaneously induced by 3-methylcholanthrene (3MC) and their corresponding transplanted tumors. The immune genes examined were Pd1, Pdl1, Pdl2, Cd3d, Cd8a, Cd8b, Ifnγ, Itga2, Gzmb, and Foxp3. Among 12 tumors, one was non-transplantable and showed a benign phenotype with an abundance of DX5+ natural killer cells and CD8+ T cells together with increased IFNγ expression and mRNA levels of all immune genes except for Itga2. The other 11 transplantable tumors showed increased expression of Pd1, Pdl1, Pdl2, Cd3d, Cd8b, and Ifnγ following transplantation into syngeneic mice. These effects of transplantation highlight the relevance of immune gene expression status to the curability of tumors. - Source: PubMed
Publication date: 2026/04/24
Tanooka HiroshiKudo-Saito ChieChiwaki FumikoIshiai MasamichiTatsumi KouichiSasaki HirokiOchiya Takahiro - There is an urgent need for the development of innovative diagnostic and therapeutic strategies in bladder cancer (BlCa) management, due to its significant incidence, mortality, and morbidity. Extracellular vesicles (EVs) constitute promising candidates as biomarkers, as their cargo is highly protected from degradation, and they can be isolated non-invasively from urine. Furthermore, they play a pivotal role in intercellular communication that drives disease progression, making them suitable candidates for tailored therapy approaches. - Source: PubMed
Publication date: 2026/04/09
Lourenço CatarinaConstâncio VeraTavares Nuno TiagoMonteiro-Reis SaraSilva-Santos RuiLobo JoãoCarvalho ÂngelaJerónimo Carmen - Pancreatic adenocarcinoma (PAAD) remains a highly lethal malignancy with limited therapeutic options, motivating the search for robust prognostic markers and tractable therapeutic targets. In this study, we applied an integrative bioinformatic pipeline combining cross-cohort differential expression analysis, high-confidence protein-protein interaction network reconstruction, and topological hub-gene prioritization. Hub candidates were then intersected with curated target repertoires of multi-target chemicals (notably quercetin and sulforaphane [SFN]) to nominate pharmacologically accessible "elite" targets. Downstream in silico validation included comparative mRNA and protein expression profiling, correlations with immune infiltration metrics, survival prognostic assessments, and molecular docking to evaluate ligand-target complementarity. This multilayered approach consistently highlighted extracellular matrix remodeling, integrin-mediated adhesion, and pericellular proteolysis as central processes in PAAD biology and identified COL1A1, ITGA2, and PLAU as top-priority targets that combine high network centrality with overlap to phytochemical target spaces. These genes demonstrated tumor-enriched expression, adverse survival associations, and distinct immune-microenvironment correlations, suggesting a potential involvement in pro-tumorigenic remodeling processes. Molecular docking analyses suggested computationally feasible ligand-target binding hypotheses, with quercetin exhibiting comparatively stronger predicted affinities than SFN across all targets. - Source: PubMed
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Publication date: 2026/03/12
Kumar VasantRay DebadritaJamwal ManuHans ChanderJain VanitaAhluwalia JasminaDas ReenaKumar Narender - The peri-implant seal established between a dental implant abutment and the surrounding gingival soft tissue, serves as the first line of defence against the oral environment. It is a critical determinant of the long-term stability and success of an osseointegrated implant. Carbon-fibre-reinforced polyetheretherketone (CFR-PEEK) is a promising alternative for metallic surgical implants. This in vitro study determined the optimal zirconia nanostructure on CFR-PEEK surfaces to enhance the response of human gingival fibroblasts (HGFs) and its antibacterial properties, thereby facilitating the peri-implant seal of gingival and dental implant abutments. - Source: PubMed
Publication date: 2026/02/28
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