Ask about this productRelated genes to: CD49e antibody
- Gene:
- ITGA5 NIH gene
- Name:
- integrin subunit alpha 5
- Previous symbol:
- FNRA
- Synonyms:
- CD49e
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-19
- Date modifiied:
- 2016-01-15
Related products to: CD49e antibody
Related articles to: CD49e antibody
- This study aimed to reveal the mechanism and prognostic significance of migrasome-related genes (MGs) in primary liver cancer (PLC) treated with Sorafenib (Sor) treatment. - Source: PubMed
Publication date: 2026/05/16
Wang LeiWan ZhaoxiaGao LinluDing FeiGao KunYin Xiaoling - Ultraviolet (UV) radiation exacerbates skin photoaging, disrupting extracellular matrix (ECM) homeostasis and thereby causing premature skin aging and increased susceptibility to damage. Effective therapeutic approaches to manage photoaging and promote skin regeneration are essential. This study developed a multifunctional nanocomposite hydrogel (CAPE@DMMg) by loading active compounds into citrate-functionalized mesoporous silica nanoparticles (CAPE@MSN-CA), incorporating a deep eutectic solvent to enhance skin penetration, and introducing magnesium ions to improve the mechanical stability of the hydrogel. Experimental results demonstrated that CAPE@DMMg scavenged reactive oxygen species, modulated ECM-related gene expression, and reduced skin wrinkles, restores skin thickness, and promotes collagen deposition, exhibiting remarkable anti-photoaging effects. Furthermore, CAPE@DMMg reduced UV-induced senescence-associated markers in multiple organs, indicating reduced systemic oxidative stress and senescence-related changes. Mechanistically, CAPE@MSN-CA restored mitochondrial function by targeting the FN1-ITGA5 axis and suppressing apoptosis. This effect was accompanied by increased type I/III collagen and reduced MMP1 and FN1 expression. In summary, this study presents a multifunctional drug delivery system that regulates ECM microenvironment homeostasis, offering a novel strategy for anti-aging skin therapy. - Source: PubMed
Publication date: 2026/04/20
Wang XiaoxiangZhou FeiBie FanXiong YahuiLi ZhanpengLiu XiaogangMo XiaoyingZhao JinglingZhang ZhaoqiangXie JulinChen Lei - Aortic dissection (AD) is a life-threatening vascular disorder characterized by medial degeneration and phenotypic switching of vascular smooth muscle cells (VSMCs). While integrin subunit alpha 5 (ITGA5) has been implicated in VSMC plasticity, the upstream molecular mechanisms governing its regulation remain poorly defined. - Source: PubMed
Publication date: 2026/05/06
Wang DongYang LingboZong Junqing - Follicular development in laying hens requires a balance between angiogenesis and redox status, yet their synergistic interplay across different production levels and physiological stages remains unclear. This study compared high-production (HP) and low-production (LP) hens at 50 and 75 weeks of age using morphological, antioxidant, angiogenic, and transcriptomic analyses. An acute tBHP-induced oxidative stress model was further employed to elucidate the temporal coupling between these systems. - Source: PubMed
Publication date: 2026/05/03
Qin KailongGao MingluLiu XiaoyingLiu YanliYang XiaojunYang Jiantao - This study aimed to comprehensively investigate the shared molecular mechanisms and intercellular communication signatures of gout and metabolic syndrome (MetS), seeking to identify and validate key regulatory genes and pathways for developing precise diagnostic and therapeutic strategies. - Source: PubMed
Publication date: 2026/04/15
Shao ZichenDeng QinqinCheng LingYang Fo