Ask about this productRelated genes to: SHBG protein
- Gene:
- SHBG NIH gene
- Name:
- sex hormone binding globulin
- Previous symbol:
- -
- Synonyms:
- ABP, TEBG, MGC126834, MGC138391
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-14
- Date modifiied:
- 2016-04-04
Related products to: SHBG protein
Related articles to: SHBG protein
- Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, imposing substantial clinical and socioeconomic burdens due to chronic pain, functional disability, and reduced quality of life. While diabetes is a well-established risk factor for CTS in observational studies, the causal nature of this association and the mediating roles of glucose levels and inflammatory pathways remain unclear. - Source: PubMed
Publication date: 2026/05/07
Wang JingQiu XuWu Xu - Lipid-based chemicals that are added to plastic materials to increase their functionality, phthalates are diesters of orthophthalic acid that contaminate various levels of the environment. Human phthalate toxicity is best recorded as endocrine disrupting chemicals, anatomical and physiological risks to a fetus, and disturbance to musculoskeletal, dermatologic, and reproductive systems. Testosterone and sex-hormone binding globulin (SHBG) are essential components for the regulation of the reproductive system, and dysregulation can result in decreased libido, anovulation, infertility, or effect on peripheral systems. The purpose of this study was to examine the correlation of urinary phthalate metabolites with abnormal testosterone and SHBG levels in the US female population aged 15-55 years. This study examines the correlation between urinary phthalate exposure and serum female hormone levels using data from the 2013-2014 and 2015-2016 National Health and Nutrition Examination Survey (NHANES). Weighted complex logistic regression analysis was conducted to assess the relationship between urinary creatinine-standardized phthalate concentrations and infertility status, as determined by serum testosterone and SHBG in females aged 15-55 years (N = 4,411). Subject demographic characteristics and medical and reproductive health conditions were included in the model as covariates. Among 4,411 study participants, the overall rate of infertility based on the testosterone (normal range: 15-70 ng/dl) was 24.2% (testosterone < 15: 22.4% and testosterone > 70: 1.8%) and rate of infertility based on the SHBG levels (normal range: 17.4-52.1 nmol/L) was 62.2% (SHBG < 17.4: 2.3% and SHBG > 52.1: 59.9%). Abnormal levels of testosterone were associated with increasing Mono-isononyl phthalate (MNP) [odds ratio (OR) = 1.041, 95% CI = 1.008, 1.075] and Cyclohexane 1,2-dicarboxylic acid monohydroxy isononyl ester (MHNCH) [OR = 1.030, 95% CI = 1.005, 1.055]. In the regression model for quantitative measures of SHBG, decreased SHBG levels were significantly associated with increased Mono(carboxyisononyl) phthalate (MCNP) (p = 0.034) and MHNCH (p = 0.002). Additionally, age, race, and BMI were significant predictors of female infertility in relation to SHBG levels. Analysis observed statistically significant correlation between testosterone-MNP, testosterone-MHNHC, SHBG-MCNP, and SHBG-MHNHC. Demographic factors associated with abnormal testosterone included age, country of birth, and alcohol use, and those associated with abnormal SHBG included age, education level, country of birth, body mass index (BMI), income status (FIPR), alcohol use, first menstrual cycle, and uterine cancer diagnosis. Further studies will be needed to determine causation and the mechanism of how phthalates affect testosterone and SHBG levels in females. - Source: PubMed
Publication date: 2026/05/09
Rahman Humairat HStokey Weston RJeon Soyoung - Sex hormones shape biological sex differences and alter the onset and severity of sleep and metabolic diseases in a sex-specific manner. To better understand relationships and underlying mechanisms, we develop summary proteomics and metabolomics scores for sex hormones and investigate their associations with sleep and metabolic disorders. - Source: PubMed
Publication date: 2026/04/28
Wang ZiqingZhang YuWood Alexis CBenson Mark DTaylor Kent DGuo XiuqingRich Stephen SClish Clary BGerszten Robert ERedline SusanRotter Jerome IGanz PeterDeo RajatDubin RuthLiu Peter YSofer Tamar - Prader-Willi syndrome (PWS) is a rare imprinting disorder characterized by typical dysmorphic features, lack of satiety, infantile hypotonia, and later morbid obesity with complications, short stature, hypogonadotropic hypogonadism, skeletal and psychiatric problems. From the literature, it is well known that patients with PWS have a more favorable metabolic pattern than healthy controls. - Source: PubMed
Publication date: 2026/05/05
Yordanova NikolinkaVasileva MilaGalcheva SonyaIotova Violeta - Past research on the health impacts of parabens has largely focused on susceptible groups like pregnant women. However, postmenopausal women, due to profound hormonal shifts, are also a sensitive yet underrecognized population. To evaluate paraben exposure patterns, we analyzed pooled urine samples from 6523 Chinese adults. Major paraben congeners (MeP, EtP, PrP, BuP, BzP) were measured to examine paraben exposure of different sexes and age groups. These descriptive data revealed distinctly elevated paraben burdens among women in midlife and older groups. To investigate the endocrine consequences of this heightened exposure, we subsequently evaluated an independent United States cohort comprising 556 premenopausal and 332 postmenopausal women. This integrative approach leverages large-scale exposure characterization from China and individual-level endocrine effect data from NHANES to explore potential susceptibility modifiers. Postmenopausal women exhibited higher sensitivity to paraben-induced disruption, indicating that menopausal status is a critical modifier. Specifically, compared to premenopausal women, postmenopausal women showed a greater increase in paraben mixtures, with an 11.2% rise in sex hormone-binding globulin (SHBG) and a 9.1% increase in the total testosterone/estradiol (TT/E) ratio, indicating a shift toward relative androgen predominance. Compared with non-obese postmenopausal women (no significant associations), overweight and obese postmenopausal women had elevated TT/E ratios with exposure to BuP (52.4%), MeP (27.1%), and EtP (30.1%). These findings strongly suggest a 'two-hit' mechanism in that menopause and obesity jointly magnify paraben-induced endocrine disruption beyond either factor individually. This heightened susceptibility challenges uniform exposure limits, necessitating the integration of menopausal and metabolic status into risk assessments. - Source: PubMed
Publication date: 2026/05/03
Yu ChaoYeerkenbieke GulijiaziQian JianpingWu ZhenghaoYao WeiXiao JianChen JieGao JianfaFu XiaofangLi Xiqing