Ask about this productRelated genes to: TIE1 protein (Fc Chimera)
- Gene:
- TIE1 NIH gene
- Name:
- tyrosine kinase with immunoglobulin like and EGF like domains 1
- Previous symbol:
- TIE
- Synonyms:
- JTK14
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-08-24
- Date modifiied:
- 2016-10-05
Related products to: TIE1 protein (Fc Chimera)
Related articles to: TIE1 protein (Fc Chimera)
- Endothelial cells (ECs) of the heart proliferate and form new vessels in response to vascular endothelial growth factor (VEGF), but VEGF has not benefited the therapy of cardiac ischemia because of its side effects. Here, we explored if deletion of the vascular steady-state homeostasis maintaining Tie1 and Tie2 receptor tyrosine kinases affects the proliferation and sprouting of cardiac ECs. - Source: PubMed
Publication date: 2026/01/21
Anisimov AndreyLackman Madeleine HAugustin Hellmut GMervaala EeroAlitalo KariKaraman Sinem - Infantile hemangioma (IH) is a common benign vascular tumor in infants, often requiring intervention due to potential functional impairment and cosmetic concerns. Propranolol, a nonselective β-adrenergic receptor blocker, is the first-line therapy for IH, yet its mechanisms remain incompletely elucidated. - Source: PubMed
Publication date: 2025/12/19
Liang LijunZhang YanMa YanLiu JingDu WangnanMa Qiang - Tie1, an orphan receptor, is a receptor tyrosine kinase that is expressed in endothelial cells. It can form a polymer with Tie2, thereby regulating the Ang/Tie2 signaling pathway, which is crucial for angiogenesis and plays a significant role in tumor progression. However, the specific role of Tie1, particularly in tumor processes, remains poorly understood. In this study, we investigated the functional effects of Tie1 knockdown in cervical cancer both in vitro and in vivo. We used CCK-8, wound healing, and Transwell assays to evaluate cervical cancer cell proliferation and migration in vitro. Additionally, we established subcutaneous xenograft tumor and lung metastasis mouse models to examine tumor growth and metastasis. The impact of Tie1 knockdown cervical cancer cell-conditioned medium on human umbilical vein endothelial cell (HUVEC) angiogenesis was assessed using an angiogenesis assay. Tie1 knockdown inhibited activation of the Tie2/PI3K/Akt signaling axis and weakened the migration and invasion abilities of cervical cancer cells in vitro and in vivo. Addition of Ang1 partially reversed the effects of Tie1 knockdown. Knockdown of Tie1 also reduces CD31 protein expression in vitro and in vivo. Tie1 derived from cervical cancer cells exerts an oncogenic role by promoting progression through activation of the Ang1/Tie2/PI3K/Akt signaling axis. These findings may provide new biomarkers and identify potential therapeutic targets for cervical cancer. - Source: PubMed
Publication date: 2025/12/17
Wei HongjianWang XinWang QixinLin BingjieLiu XinyanShi Yonghua - In the development of new drugs, one of the leading causes of late-stage failures are off-target adverse effects, but they are difficult to predict before expensive large-scale clinical trials. Proteomic changes observed in randomized controlled trials (RCTs) and Mendelian randomization estimates of the effects of these changes can provide valuable evidence about the likely effects of drugs on health outcomes. We provide proof of principle for this approach using data from the ILLUMINATE trial of torcetrapib, a drug developed to increase high-density lipoprotein (HDL) cholesterol while reducing low-density (LDL) cholesterol, but which unexpectedly increased blood pressure and mortality. We used Mendelian randomization to estimate the causal effects of 95 proteins perturbed by 3 months of torcetrapib exposure on 19 health outcomes. Six proteins showed concordant effects with the results of the trial, including C-type mannose receptor 2 (MRC2), cGMP-specific 3';5'-cyclic phosphodiesterase (PDE5A), Spondin-1 (SPON1), and Tyrosine-protein kinase receptor Tie-1 (TIE1), which increased blood pressure in the same direction as their observed protein. Our results demonstrate a generalizable genetic-proteomic framework for predicting likely adverse drug effects, reducing potential harm to patients and drug failure costs. - Source: PubMed
Publication date: 2025/12/04
Brody Jenifer ASitlani Colleen MPsaty Bruce MYe TingGanz PeterFloyd James SDavies Neil M - This study evaluated the long-term metabolic effects of prenatal nutrition in Nellore bulls. Pregnant cows (n = 126) received mineral supplementation only (NP), protein-energy supplementation during the last trimester (PP), or supplementation throughout pregnancy (FP). At slaughter, longissimus (muscle and meat) and subcutaneous fat samples from the offspring were collected for transcriptomics and metabolomics analyses. Data were reduced using Weighted Gene Co-expression Network Analysis, followed by functional enrichment, and then integrated via Spearman's correlations and holistic pathway analysis. Distinct molecular patterns emerged across prenatal nutrition treatments, although all groups influenced energy metabolism and cellular processes. The NP group was strongly associated with protein and lipid metabolism, highlighted by PPAR and sphingolipid signaling pathways, and key hub components including CNOT4 and tryptophan. In contrast, PP and FP groups were more closely linked to immune function, stress resilience, with enrichment of NF-kB signaling, cortisol synthesis, and hub components including TIE1, YWHAZ, carnitine, and glutaconylcarnitine. Shared transcriptome-metabolome modules between groups displayed inverse correlations, suggesting potential antagonistic effects driven by maternal diet. Overall, these results indicate that prenatal nutrition shapes key metabolic processes in muscle, meat, and fat, offering insights to enhance meat quality and production through maternal feeding strategies. - Source: PubMed
Publication date: 2025/12/13
Polizel Guilherme Henrique GebimCánovas ÁngelaDiniz Wellison J SRamírez-Zamudio German Dda Luz E Silva SauloDahlen Carl RFernandes Arícia ChristofaroPrati Barbara Carolina TeixeiraFurlan Édisondo Vale Pombo Gabrielade Almeida Santana Miguel Henrique