Ask about this productRelated genes to: LYVE1 protein
- Gene:
- LYVE1 NIH gene
- Name:
- lymphatic vessel endothelial hyaluronan receptor 1
- Previous symbol:
- XLKD1
- Synonyms:
- LYVE-1
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2015-07-22
Related products to: LYVE1 protein
Related articles to: LYVE1 protein
- - Source: PubMed
Takagaki Kazuki - To investigate the mechanism of Huiyang Shengji unguent (, HYSJ) for improving inflammation and promoting wound healing in patients with diabetic foot. - Source: PubMed
Fangning Y ULi LinXiao TangXiujuan H EBo ZhangYukun ChenYizhao M AZeyu LiuJinsheng Y EXuying X U - This study investigated the mechanism of pirfenidone (PFD) inhibiting metastasis of lung cancer in vivo.A nude mouse lung cancer model was established and treated with PFD (200, 400 μg/mL); lung metastatic tumor weight was recorded, Lyve-1 (lymphatic marker), LC3II (autophagy protein) and polo-like kinase 1 (PLK1) were detected. In human lung lymphatic endothelial cells (HMVEC-LLy) cells, PFD's effects on migration, apoptosis, lymphangiogenesis, and LC3II/LC3I/PLK1 levels were tested. PLK1-overexpressed HMVEC-LLy cells were treated with 400 μg/mL PFD to explore its mechanism. PFD inhibited the weight of lung metastases and down-regulated the expression levels of Lyve-1, LC3II/LC3I and PLK1. In cell experiments, PFD was found to inhibit HMVEC-LLy migration, apoptosis and lymph angiogenesis, as well as down-regulate LC3II/LC3I and PLK1 protein levels, and these effects could be reversed by PLK1 overexpression.PFD may inhibit lung cancer metastasis in vivo by regulating lymph angiogenesis through PLK1 signaling. - Source: PubMed
Publication date: 2026/04/21
Xia ZehaiWang QuanZheng LeiLv Qun - The anatomical localization of lymphatic vessels in bone remains controversial and has led to conflicting interpretations of skeletal lymphatic function. Here we assessed lymphatic identity and localization in bone using mouse genetic labeling, tissue clearance, and three-dimensional imaging. We analyzed long bones after extensive periosteum removal and identified Vegfr3 blood vessels lacking Lyve1 expression within bone marrow, whereas Vegfr3 Lyve1 lymphatic vessels were confined to residual periosteal regions. Genetic lineage tracing using Prox1-Cre/ER;mScarlet further confirmed that lymphatic vessels are absent from long bone marrow and restricted to periosteal compartments, particularly in fibrous but not cambial layers. Extending these analyses to the mandible, we observed Vegfr3 Lyve1 lymphatic vessels localized to periarticular soft tissues surrounding the temporomandibular joint (TMJ), while mandibular bone marrow contained only Vegfr3 Lyve1 blood vessels and lacked Prox1 lineage-traced lymphatic vessels. Together, these findings establish that lymphatic vessels in bone are confined to periosteal and periarticular compartments and absent from bone marrow, providing a framework for interpreting lymphatic contributions to skeletal physiology and disease. - Source: PubMed
Publication date: 2026/04/08
Chang QingShu YangLiu HongzhiKo Pao-FenChen Jian-Fu - Recent studies in mouse models have demonstrated that macrophages in adult tissues are maintained not only by the differentiation of bone marrow-derived monocytes but also by the proliferation of macrophages originating from the yolk sac or fetal liver. However, the extent to which this paradigm shift occurs in human tissues is not fully understood. In this study, we detected a human peritoneal macrophage subset that exhibited embryonic origin-like phenotypes. Macrophages in the ascites of patients with gastric cancer were divided into CCR2 and CCR2 subsets, the ratios of which varied among donors. The gene expression profiles of these subsets were similar to those of the macrophage subsets in the heart. CRIg was recently reported as a marker for distinguishing between two macrophage subsets in the ascites of patients with cirrhosis. CCR2 and CCR2 subsets expressed high and low levels of CRIg, respectively. Importantly, the CCR2CRIg subset expressed the cell proliferation marker Ki67 and the recently proposed core markers (TIMD4, LYVE1, and FOLR2) of embryo-derived macrophages at higher levels than the CCR2CRIg subset. Moreover, many other markers shared by TIMD4LYVE1FOLR2 macrophages in heart, lung, kidney, and liver exhibited similar expression patterns in the peritoneal CCR2CRIg subset. These results suggest that the CCR2CRIg subset in the peritoneal cavity contains macrophages with embryonic origin. - Source: PubMed
Publication date: 2026/04/16
Takahashi NaofumiHabash Sara AKomohara YoshihiroUsuki ShingoYasunaga Kei-IchiroHino ShinjiroAbdelnaser Randa AEinarsdottir ThorbjorgNomura TakushiYonemura AtsukoIshimoto TakatsuguSuzu Shinya