Ask about this productRelated genes to: LYVE1 protein
- Gene:
- LYVE1 NIH gene
- Name:
- lymphatic vessel endothelial hyaluronan receptor 1
- Previous symbol:
- XLKD1
- Synonyms:
- LYVE-1
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2015-07-22
Related products to: LYVE1 protein
Related articles to: LYVE1 protein
- Metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver pathological condition, develops due to complex interactions among various hepatic cell types. Emerging evidence demonstrates the pivotal role of hepatic endothelium, specifically the liver sinusoidal endothelial cell (LSEC) phenotype, in MASLD pathogenesis. While global ablation of leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) improved metabolic fitness in mice, its cell-specific deletion revealed differential phenotypes. Here, we investigated the endothelial cell (EC)-specific role of Lgr4 in regulating LSEC phenotype and MASLD development. - Source: PubMed
Publication date: 2026/09/16
Aithabathula Ravi VarmaCollier Daniel MSingal VarunRairao SrijaIslam Rifat AraSvetich BriannaSingla Bhupesh - : Congenital pulmonary airway malformation (CPAM) is a rare developmental disorder characterized by cystic lung lesions, yet its extracellular matrix (ECM) composition remains poorly understood. This study employed decellularization and data-independent acquisition (DIA) proteomics to compare ECM profiles between cystic (CPAM) and histologically normal non-diseased (ND) regions from the lungs of four patients. : The decellularized scaffolds retained their native architecture with minimal residual DNA (<50 ng/mg). Proteomic analysis revealed 431 differentially expressed proteins (DEPs), with 171 upregulated and 260 downregulated in CPAM. Key findings revealed CPAM-specific enrichment of collagens (COL4A6, COL4A2, COL10A1, COL21A1 and PIIINP), glycoproteins (SPP1, FRAS1, FREM1, FREM2, LTBP1 and FBLN7), ECM regulators (TENM2, ROR2 and OMD), and ECM-affiliated proteins (ANXA7), alongside downregulation of glycoproteins (VASN and ABI3BP), proteoglycans (PODN and MXRA7), ECM regulators (SCARA5, PAPPA, SAA4, CPXM1, CTSC, THY1, SERPINA6/A1/D1, BSG, LYVE1, ITIH4 and CD44), and ECM-affiliated proteins (LGALSL). Pathway analysis highlighted the dysregulation of TGF-β, PI3K-AKT, and mTOR signaling in CPAM and aberrant ECM-cell interactions in pathogenesis. We also evaluated their functional properties and investigated the impact of ECM-based hydrogels on recellularization. : These findings provide a comprehensive proteomic atlas of CPAM ECM alterations, offering insights into disease mechanisms and potential therapeutic targets. - Source: PubMed
Publication date: 2026/08/30
Li YananYang PingYuan MiaoZhu XinglongMao ShengqiangYang YingYao MenglinChen FeiZhou YanyanBao JiXu ChangLi Yi - Severe asthma is a chronic inflammatory disease characterised by airway dysfunction, persistent immune activation and corticosteroid resistance. While macrophages are key regulators of lung immunity, how individual subsets, particularly interstitial macrophages (IMs), contribute to disease remains poorly understood. - Source: PubMed
Wang HaoFung Nok HimAloe ChristianKermani Nazanin ZounematAdcock Ian MSelemidis StavrosVlahos RossMcQualter JonathanBozinovski Steven - Endothelial cells were among the first cells identified to have a surface glycocalyx, but its functions are still elusive. Within the glycocalyx are many glycoproteins whose O-glycosylation is partly regulated by Cosmc, an essential chaperone for functional activity of T-synthase that adds galactose to O-glycans initiating their elongation. Using mice with inducible deletion of either Cosmc (C1Galt1C1) or the sialyltransferase St3Gal-1 in lymphatic endothelial cells (LEC), we discovered that loss of elongated O-glycans is accompanied by major changes in glycoprotein composition, including podoplanin, CD44, Lyve-1, and ICAM-1. These changes in the endothelial glycocalyx are sensed by adhesion molecules, such as Siglec-1, and lead to major changes in the size and phenotype of lymph node macrophage populations. Our findings demonstrate the crucial roles of O-glycosylation in regulating LEC functions and lymph node macrophage differentiation. - Source: PubMed
Frey JasminRatter AnnkathrinBrigger FinnCielen LouieKunz PascalTulin EaMikos KingaDieterich LotharD'Addio MarcoHalin CorneliaCummings Richard DOtto Vivianne I - Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) has been recognized as a marker of lymphatic vessels; however, recent studies have reported that LYVE-1 is expressed in diverse cell types and functionally contributes to organ repair. Herein, we examined the expression pattern of LYVE-1 in acute respiratory distress syndrome (ARDS) model mice. - Source: PubMed
Publication date: 2026/08/22
Matsunaga ShuntaroTakamori ShinnosukeLin ShenMan ChenMizuta YukieNarahara SayokoKawano TakahitoMurata MasaharuAkahoshi Tomohiko