Ask about this productRelated genes to: VEGFR2 protein
- Gene:
- KDR NIH gene
- Name:
- kinase insert domain receptor
- Previous symbol:
- -
- Synonyms:
- FLK1, VEGFR, VEGFR2, CD309
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2019-04-23
Related products to: VEGFR2 protein
Related articles to: VEGFR2 protein
- Scanning genomes for selection signals could illuminate the impact of domestication, natural, and artificial selection on the phenotypic traits of cattle breeds. The present study investigated the diverse genomic selection signatures using whole genome sequencing data from 15 pooled samples of five indigenous cattle breeds of Tamil Nadu: Alambadi, Bargur, Kangayam, Pulikulam, and Umblachery. Two approaches, namely composite likelihood ratio (CLR) and fixation index (), were employed to detect selection signatures from the 1,390,449 filtered single-nucleotide polymorphisms. The analysis identified 7250 and 806 genomic regions containing selective sweeps in 1238 and 101 candidate genes using CLR and methods, respectively. These regions were predominantly associated with production traits ( and ), coat colour ( and ), disease resistance ( and ), and adaptation to tropical climates ( and ). Particularly, six regions were shared across all the five cattle breeds, of which, five were intergenic regions and one had a candidate gene, , associated with susceptibility to bovine tuberculosis. A total of 12 candidate genes were common between CLR and methods, relating to production, disease resistance, and behavioural traits. NETWORK analysis revealed six candidate genes allied with calving ease ( and ), milk fat yield (), bovine respiratory disease susceptibility ( and ), and meat and carcass traits (). This study presents the first genomewide map of selective sweeps in Tamil Nadu cattle breeds, providing insights into selection signatures and candidate genes that could enhance genomeassisted breeding for improved production and health. - Source: PubMed
Vani SBalasubramanyam DSingh KaranbirKarthickeyan S M KTirumurugan K GGopinathan AHepsibha PMadhuri B Jaya - Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis and an established therapeutic target in diseases such as cancer and ocular disorders. However, long-term use of most current anti-VEGF agents is often limited by their associated side effects, including hypertension, bleeding, and gastrointestinal complications. These limitations have stimulated interest in naturally occurring VEGF inhibitors derived from dietary sources, which may offer safer alternatives due to their favorable safety profiles. In this study, we investigated shared structural features of potent VEGFR2 inhibitors, focusing on naturally derived polyphenols. Polyphenols representing multiple structural subclasses were evaluated for their ability to inhibit VEGFR2 kinase activity using an in vitro kinase assay, to suppress VEGF-induced phosphorylation of VEGFR2 and downstream MAPK signaling in endothelial cells by Western blot, and to reduce VEGF-stimulated endothelial cell proliferation. Across all assays, flavonoids with strong VEGFR2 inhibitory activity displayed consistent structural characteristics, including the number and specific positioning of hydroxyl groups on the A- and B-rings, as well as specific structural elements of the C-ring. Our findings provide a strong foundation for further structure-activity relationship (SAR) studies and facilitate identification of key molecular determinants required for VEGFR2 inhibition. Elucidation of these structural patterns may contribute to the development of more effective and safer angiogenesis inhibitors with reduced adverse effects. - Source: PubMed
Publication date: 2026/04/18
Yim AndrewLu JianmingWen Wei - Follicular development in laying hens requires a balance between angiogenesis and redox status, yet their synergistic interplay across different production levels and physiological stages remains unclear. This study compared high-production (HP) and low-production (LP) hens at 50 and 75 weeks of age using morphological, antioxidant, angiogenic, and transcriptomic analyses. An acute tBHP-induced oxidative stress model was further employed to elucidate the temporal coupling between these systems. - Source: PubMed
Publication date: 2026/05/03
Qin KailongGao MingluLiu XiaoyingLiu YanliYang XiaojunYang Jiantao - Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous mesenchymal tumours sharing clinical and histopathological features. Compared to AFX, PDS has an increased risk of local recurrence and metastasis. A precise diagnosis is critical to ensure proper clinical management and follow-up. AFX and PDS show a similar genetic background, but also a heterogeneous pattern of different molecular abnormalities still poorly investigated due to the rarity of these tumours. Multiple data from different institutions and geographical areas, facilitate the identification of molecular alteration/s of valuable diagnostic and/or sub-classification power. We investigated the DNA profile of 32 AFX and PDS samples using a custom targeted Next-Generation Sequencing panel including 228 cancer genes. We confirm a common pattern of gene mutations affecting TP53, CDKN2A and NOTCH1. Differences appeared in less frequently detected genes (e.g. TSC2) and in NF2 harbouring novel genetic alterations. Integrating our results with published datasets of AFX and PDS mutation profiles we observed a divergent distribution of alterations in genes signalling through angiogenic pathway (KDR, PDGFRB), DNA damage response (ATR), cellular migration/metastasis (DDR2, CDH1). These differences do not reach statistical significance, and histopathological evaluation remains the diagnostic gold standard, however, they offer valuable insights into the pathogenesis of these tumours. - Source: PubMed
Publication date: 2026/05/03
Caprini ElisabettaScaglione Giovanni LucaScarponi ClaudiaMorelli MartinaMadonna StefaniaMarani CarlaSebastiani ValeriaScala EnricoAlbanesi CristinaRahimi Siavash - In this study, a novel series of chromene-based derivatives was rationally designed as potential VEGFR-2 inhibitors based on key structural and pharmacophoric features required for antiangiogenic activity. Accordingly, twelve chromene derivatives (13a-e, 15a-e, and 17a-b) were successfully synthesized and structurally characterized. The synthesized compounds were evaluated in vitro for their cytotoxic activity against human cancer cell lines (MCF-7, HepG-2, and HCT-116), in addition to normal WI-38 and WISH cells. Among the tested compounds, compound 13a demonstrated the most potent and selective antiproliferative activity, exhibiting low micromolar IC values and favorable selectivity indices. Enzymatic assays confirmed its VEGFR-2 inhibitory activity (IC = 1.666 ± 0.025 µM), comparable to the reference drug sorafenib. Mechanistic investigations revealed that compound 13a effectively inhibited cancer cell migration in a wound healing assay, highlighting its potential antiangiogenic properties. Furthermore, compound 13a induced significant G0/G1 cell cycle arrest in MCF-7 cells and triggered apoptosis, as evidenced by Annexin V/PI staining. To support the experimental findings, Density Functional Theory (DFT) calculations confirmed favorable structural stability and electronic properties. Molecular docking studies demonstrated strong binding interactions within the VEGFR-2 ATP-binding site. These results were further validated by 200 ns molecular dynamics simulations, MM-GBSA binding free energy calculations, Protein-Ligand Interaction Fingerprints (Pro-LIF), Principal Component Analysis of Trajectories (PCA-T), and Free Energy Landscape (FEL) analyses, confirming the dynamic stability and favorable energetics of the VEGFR-2-13a complex. Overall, this integrated experimental and computational study identifies compound 13a as a promising VEGFR-2-targeted anticancer lead warranting further preclinical investigation. - Source: PubMed
Elkady HazemElgammal Walid EEissa Ibrahim HMahdy Hazem AAlsfouk Aisha AAmin Fatma GHusein Dalal ZMetwaly Ahmed MElkaeed Eslam B