Ask about this productRelated genes to: CD105 antibody
- Gene:
- ENG NIH gene
- Name:
- endoglin
- Previous symbol:
- ORW1, ORW
- Synonyms:
- END, HHT1, CD105
- Chromosome:
- 9q34.11
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-03
- Date modifiied:
- 2019-04-23
Related products to: CD105 antibody
Related articles to: CD105 antibody
- Additive manufacturing (AM) is increasingly applied to lower-limb prosthetic sockets, offering faster production, lower cost, and improved customisation. Multi-material additive manufacturing (MMAM) enables rigid and flexible regions to be combined in a single socket, potentially improving load distribution and user comfort. However, research on MMAM remains limited and is distributed across engineering, biomechanical, and clinical disciplines. - Source: PubMed
Publication date: 2026/04/24
Alharbi SattamSewell PhilipDyer BryceBatley AbigailMontalvão Diogo - Scalable, continuous biomanufacturing processes have grown in importance to meet demand for smaller bioreactor sizes, lowered production costs, and improved quality attribute consistency. The Sf9/recombinant baculovirus (rBV) expression system demonstrates promise for virus-like particle (VLP) vaccine and gene therapy production. Here, we present a continuous rBV platform integrating an infection plug flow reactor (PFR) between stirred tank growth (gCSTR) and production (pCSTR) bioreactors. Cell expansion in the gCSTR included a ramp-up stage followed by continuous growth, reaching a steady state of 5×10 cells/mL and >90% viability. Péclet number-fit tracer studies confirmed near-ideal plug flow in the PFR, yielding a 10 h residence time and progressive infection as measured by gp64 signaling. Finally, a pCSTR with a residence time of 48 h exhibited sustained recombinant protein production. An integrated pilot cascade incorporating all reactors ran continuously for 5 days, maintaining stable CSTR cell densities and a measurable increase in infected cell diameter from 14.5 μm to 16.1 μm. Western blotting and EM of ~ 100 nm VLPs in pCSTR effluent demonstrated platform success. Digital twin mechanistic models across four distinct stages of bioreactor operation and Hill-type relationships for rBV infection kinetics predicted cell growth and death for a 7-day run, demonstrating promise for designing continuous systems in silico and building a quantitative framework for scale-up and optimization. Our multi-stage reactor configuration represents a cell host- and product-agnostic production scheme, particularly for processes prone to product heterogeneity, and paves the way towards a true end-to-end continuous platform for myriad modalities in the future. - Source: PubMed
Publication date: 2026/04/24
Sargunas JustinPriem BradleyCarman DylanSarvari TaravatNold Natalie MSharma VaishaliPekosz AndrewHeldt Caryn LBetenbaugh Michael - Photosensitivity is central to cutaneous lupus erythematosus and dermatomyositis (DM), but the mechanisms linking UVB exposure to tissue-specific autoimmunity are poorly defined. Using single-cell RNA sequencing, spatial transcriptomics, proteomics, UVB provocation and in vitro modeling, we identify MMP9⁺CD14⁺ myeloid cells as critical mediators of photosensitivity. These cells expand significantly in lesional skin, produce interferon-β (IFNβ) and colocalize with cytotoxic CD4⁺ T cells at the dermal-epidermal junction. Keratinocytes activate fibroblasts in the superficial dermis, prompting them to release chemokines (CCL2, CCL19, CCL7, CCL8) that recruit MMP9⁺CD14⁺ cells. In vitro, type I interferon-primed keratinocytes exposed to UVB release cytokines activating dendritic cells, mirroring in vivo responses. UVB irradiation of non-lesional skin of patients with DM rapidly recruits these myeloid cells. In a clinical proof-of-concept study, anti-type I interferon treatment with anifrolumab prevented UVB-induced myeloid infiltration and reduced photosensitivity. Therefore, targeting MMP9⁺CD14⁺ cells may offer therapeutic potential for managing photosensitive autoimmune skin conditions. - Source: PubMed
Publication date: 2026/04/24
Wang YuqingAfshari KhashayarHaddadi Nazgol-SadatLopes Carolina SalomãoEng Chee-Huat LinusWhiteman Leah MMartinez NuriaKyawe Pyae PAnufrieva Ksenia SWei KevinFrieda KirstenRosenbach MishaVleugels Ruth AnnGallucci StefaniaHarris John ERashighi MehdiGarber Manuel - Molecular dynamics (MD) simulations have become a powerful tool for studying polymers, designing new materials, and composites. Mechanical behavior in MD simulations are typically evaluated through stress-strain curves. However, MD-generated stress-strain curves are often obscured by thermal noise from atomic vibrations. This noise complicates the reliable derivation of mechanical properties and hinders objective and reproducible analysis. The noise in the stress-strain curves has been removed by using a Butterworth low-pass filter, enabling clearer interpretation of stress-strain data. Building on this, a novel analysis framework the Regression Fringe Response (RFR) is introduced to systematically determine the Young's modulus, yield strength, and Poisson's ratio from filtered stress-strain curves. The RFR-method is explained, considerations for phenomena such as toe regions and plasticity are incorporated, and validation is performed across a range of polymer systems. The results demonstrate that RFR-method provides an accurate, robust, and reproducible approach for quantifying mechanical properties from MD simulations. - Source: PubMed
Publication date: 2026/04/24
Kemppainen JoshMuzzy TristanWavrunek Trevor KOdegard Gregory M - Breast cancer remains a leading cause of mortality among women, with brain metastatic breast cancer (BMBC) posing significant challenges due to poor prognosis and therapy resistance. Dormant tumor cells evade treatment, risking late relapse and highlighting the need to study dormancy-associated resistance mechanisms. We employed a biomimetic hyaluronic acid (HA) hydrogel to induce dormancy and suspension culture to promote proliferation, allowing comparison of dormant vs. proliferating BMBC spheroid responses to chemotherapy and targeted therapy. Proliferating spheroids exhibited reduced proliferation and increased apoptosis following treatment, whereas dormant spheroids showed minimal changes, indicating resistance. In proliferating spheroids, the ratio of percentage phosphorylated-ERK/p38 positive cells decreased post-treatment, indicating susceptibility, while dormant spheroids maintained dormancy-associated signaling. Transferring spheroids from HA hydrogel to suspension reversed dormancy, and restored therapy response. Additionally, p38 MAPK inhibition reactivated dormant spheroids, enhancing therapeutic sensitivity. This platform may aid in studying dormancy-associated drug resistance, potentially guiding more effective BMBC therapies. - Source: PubMed
Publication date: 2025/11/03
Sarker ParomitaShevde Lalita ARao Shreyas S