Ask about this productRelated genes to: ICAM1 antibody
- Gene:
- ICAM1 NIH gene
- Name:
- intercellular adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- BB2, CD54
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-24
- Date modifiied:
- 2016-01-15
Related products to: ICAM1 antibody
Related articles to: ICAM1 antibody
- Human rhinoviruses (HRVs) are major etiological agents of upper respiratory tract infections and are strongly associated with asthma exacerbations and chronic obstructive pulmonary disease, yet no approved antiviral therapies are currently available. Reverse genetics systems, particularly reporter viruses, are critical for facilitating antiviral discovery; however, robust and broadly applicable HRV infectious clones remain limited. Here, we recovered a viral genome from a clinical sample and generated infectious cDNA clones of an HRV-A1 strain, designated HRV-fd. Both the wild-type virus and a Nanoluc (Nluc) reporter virus exhibited efficient replication in HeLa cells without inducing pronounced cytopathic effects and were capable of infecting HeLa-ICAM1 cells at extremely low inocula. Leveraging the reporter virus, we conducted a drug-repurposing screen and identified pyrvinium pamoate as an antiviral compound that targets multiple steps of the HRV infection cycle, exhibiting an IC of 58.6 nM, an IC of 193.1 nM, and a CC of 3.4 μM. Notably, pyrvinium pamoate conferred sustained antiviral activity following transient exposure and subsequent withdrawal, suggesting the induction of host cellular alterations that restrict viral amplification. Collectively, these findings establish a robust HRV-A1 reverse genetics and reporter platform for virological studies and antiviral screening, and identify pyvinium pamoate as a promising lead compound for the development of effective anti-HRV therapeutics. - Source: PubMed
Publication date: 2026/04/21
Pang LinlinZou JingyiYuan ZhenghongZhao PingYi Zhigang - Gastrointestinal stromal tumors (GIST) can become malignant upon recurrence and metastasis, yet no drugs specifically target these processes. This study explores the effectiveness and mechanism of paeoniflorin in treating GIST. Initially, the impact of paeoniflorin on the viability, proliferation, and migration of GIST cell lines (GIST-T1 and GIST-882) was assessed using CCK-8, transwell, and wound healing assays at low (5 μM) and high (20 μM) concentrations. Subsequently, datasets GSE136755 and GSE21315 were analyzed to identify potential therapeutic targets for inhibiting GIST transfer. Key genes and pathways related to Paeoniflorin's anti-GIST effects were identified through molecular docking and Western blotting. Paeoniflorin influenced cell viability, proliferation, and migration in GIST-T1 and GIST-882 cell lines at low (5 μM) and high (20 μM) concentrations. We identified 761 differentially expressed genes (DEGs) and selected 50 hub genes using a PPI network. By screening paeoniflorin's potential targets, we identified eight key genes (CYP1A2, CYP2C9, CYP3A4, F2, ICAM1, NR1H4, PLG, and SERPINE1) that were significantly elevated in metastatic GIST samples. CYP3A4 was confirmed as a target of Paeoniflorin in GIST treatment through molecular docking and Western blotting. Pan-cancer analysis showed CYP3A4's enrichment in the tight junction pathway and a significant negative correlation with AKT2 protein. Paeoniflorin treatment led to high AKT2 expression in the tight junction pathway in GIST cell lines. Paeoniflorin acts on the CYP3A4 protein to affect the tight junction pathway, inhibiting the malignant metastasis of GIST. - Source: PubMed
Publication date: 2026/04/23
Cui DapengCui ZeyinLi YansenFan ShuangLi LeiYang ChengYu RuixiaCui JiaxinFu RunjiaFei Jiandong - Xuebijing (XBJ) has demonstrated efficacy in alleviating clinical symptoms in sepsis patients; however, its underlying mechanism requires further investigation. - Source: PubMed
Publication date: 2026/04/23
Meng XiaoyanYan XinmingKan ChenLi HaiquanHan DaheGuo YiXue PengJiang Yuxin - Aortic valve disease (AVD) is a cardiovascular disorder highly prevalent in the elderly population. Aortic valve leaflets suffer hardening due to extracellular matrix (ECM) remodeling and subsequent calcification, leading to impaired blood flow and aortic valve stenosis. Valve interstitial cells (VICs) are fibroblast-like cells that can undergo myofibroblast activation and osteogenic transformation, contributing to disease progression. - Source: PubMed
Publication date: 2026/04/07
Macarie Răzvan DȚucureanu Monica MCiortan LetițiaPreda Mihai BogdanMânduțeanu IleanaButoi Elena - Restoring normal morphology and function after craniofacial fractures remains a clinical challenge. Tissue engineering, particularly through cell-free approaches using secretome (soluble proteins and extracellular vesicles), has emerged as a promising strategy for enhancing bone regeneration. This study aims to evaluate the effectiveness of secretome therapy for craniofacial bone regeneration in animal and human models. - Source: PubMed
Publication date: 2026/04/21
Oley Mendy HOley Maximillian CSuoth Stevy CYong HengkiFaruk MuhammadSukarno VaniaGunawan Deborah Florencia