Ask about this productRelated genes to: GDF3 antibody
- Gene:
- GDF3 NIH gene
- Name:
- growth differentiation factor 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-23
- Date modifiied:
- 2016-10-05
Related products to: GDF3 antibody
Related articles to: GDF3 antibody
- - Source: PubMed
Publication date: 2026/07/18
Xia FangqiHu YaqiWang YaqiXue MengzhenZhu LeiqiLi YuanyangZhang YifanWang ShuwenWang RuiYuan QiHe YuminYuan DingZhang JihongYuan Chengfu - Prostate cancer is a prevalent disease with diverse tumor characteristics that complicate treatment. The integration of spatial patterns from prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT), pathology and expanding genomic data represents a groundbreaking advancement in histo-imaging genomics. The aim of this study was to elucidate the internetwork mapping between genetic biomarkers and PSMA PET/CT imaging in prostate cancer patients. - Source: PubMed
Publication date: 2026/07/04
Qu LiliLi KaiyueWang MuwenXiao YadiJin XinZhou HangYuan LujieLi YuekaiWang ShiweiLi RuiHacker MarcusLi XinLi Xiang - - Source: PubMed
Publication date: 2026/06/28
Xia FangqiHu YaqiWang YaqiXue MengzhenZhu LeiqiLi YuanyangZhang YifanWang ShuwenWang RuiYuan QiHe YuminYuan DingZhang JihongYuan Chengfu - The coordination of cell migration and proliferation is essential for embryogenesis and tissue homeostasis. However, the classical gradient signaling model is insufficient to explain how stable mitogenic signaling is maintained within migratory cells. Here, we reveal that primordial germ cells (PGCs) in zebrafish employ migrasomes-vesicular organelles formed during migration-to couple their proliferation with migration, ensuring germline expansion. Migrasomes, generated at retraction fibers via tspan7-dependent biogenesis, deliver the growth factor GDF3 specifically to neighboring PGCs through contact-dependent interactions. GDF3 activates the TGF-β receptor acvr1ba, driving proliferation in a spatiotemporally restricted manner. This homocrine signaling mechanism allows migrating PGCs to autonomously sustain proliferation, circumventing signal dilution in embryonic environments. This work uncovers migrasomes as a bridge linking migration and proliferation, with implications for understanding collective cell behaviors in development and disease. - Source: PubMed
Publication date: 2026/04/10
Liu BoqiJiang ZhengSong WenhaoZhai ZhaochengLi YaqiZhang WeiyingMeng AnmingYu Li - Mesenchymal stromal cells (MSCs) of various origins promote regeneration through paracrine signaling, immune modulation, and angiogenesis support. Premature ovarian failure (POF) is an excellent model to study coordinated ovarian and uterine repair, as cytotoxic injury simultaneously depletes ovarian follicles and impairs uterine receptors, resulting in infertility. - Source: PubMed
Borutinskaitė Veronika ViktorijaKrastinaitė IndrėValatkaitė ElvinaZentelytė-Vilkė AistėNavakauskienė Rūta