Ask about this productRelated genes to: IL12 antibody
- Gene:
- IL12RB1 NIH gene
- Name:
- interleukin 12 receptor subunit beta 1
- Previous symbol:
- IL12RB
- Synonyms:
- CD212
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-14
- Date modifiied:
- 2019-04-23
Related products to: IL12 antibody
Related articles to: IL12 antibody
- Mendelian susceptibility to mycobacterial disease (MSMD) is a rare syndrome characterized by increased and selective susceptibility to weakly virulent mycobacteria and other intramacrophagic pathogens. This study emphasizes the utility of immunological and functional assays in diagnosing MSMD by analyzing clinical, immunological, and genetic features in 50 Indian patients. Immunological workup included lymphocyte subset analysis, nitroblue tetrazolium test (NBT), and flow cytometric assessment of IFN-γR1 (CD119), IL-12Rβ1 (CD212), and phosphorylated STAT1/STAT4 following cytokine stimulation. Functional assays measured IFN-γ and IL-12p70 production. Genetic evaluation was performed using whole-exome or Sanger sequencing. The median age at onset was 3 mo. BCG complications were the most common presentation (96%), while 4% had non-tuberculous mycobacterial infections. Additional infections included , spp., spp., and multiple types of viruses. IL-12Rβ1 deficiency was the most frequent diagnosis, with 10 novel variants in the gene identified. These results demonstrate that combining flow cytometry with functional and genetic analyses enables accurate and timely MSMD diagnosis. - Source: PubMed
Publication date: 2025/12/18
Dalvi AparnaTemkar LavinaDesai MukeshGarg SwatiAluri JahnaviHule GouriBargir Umair AhmedSetia PriyankaKambli PriyankaDhawale AmrutaTamhankar ParagYadav Reetika MalikBhattad SagarSivasankaran MeenaLashkari Harsha PrasadKacha AsrutiBharathi T KasiKanakia SwatiGandhi Kamana ArunShelar ShraddhaShinde ShwetaJodhawat NehaKawale RameshSalve NitinCasanova Jean-LaurentBustamante JacintaMadkaikar Manisha R - Lung cancer is the leading cause of cancer-related death in the world. Blimp-1 is a transcriptional repressor that, by interacting with other transcription factors in lymphocytes, regulates their cellular fate. - Source: PubMed
Publication date: 2026/04/15
Finotto SusettaChiriac Mircea TKrammer SusanneYang ZuqinNeurath LauraGeppert Carol INendel ElvedinaTrump SonjaGeiger AdrianaWirtz StefanZundler SebastianNeurath Markus F - Although pediatric asthma is closely associated with dysregulated inflammatory cytokines, integrated analyses of inflammatory cytokine-related genes and their potential diagnostic biomarkers remain limited. - Source: PubMed
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Gao Mi MiWang XueYin LiWei Xiao YingLi Fang - - Source: PubMed
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Zhang WenjingZhang ZhenzhenLiu CongYang XiTang WenjingXing ShubinChen RanTang XuemeiZhang ZhiyongDing YuanZhou LinaJia YanjunAn YunfeiZhao Xiaodong - The tumor microenvironment (TME) promotes immune evasion by fostering regulatory immune programs. Although CD8 regulatory T cells have been described, their identity, upstream drivers and impact in tumors remain incompletely defined. - Source: PubMed
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