Ask about this productRelated genes to: IL12 antibody
- Gene:
- IL12RB1 NIH gene
- Name:
- interleukin 12 receptor subunit beta 1
- Previous symbol:
- IL12RB
- Synonyms:
- CD212
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-14
- Date modifiied:
- 2019-04-23
Related products to: IL12 antibody
Related articles to: IL12 antibody
- Acute myocardial infarction (AMI) increases the risk of arrhythmias, particularly ventricular arrhythmias (VA), and atrial fibrillation (AF) is also common after AMI. The paraventricular nucleus (PVN) is a key regulator of sympathetic outflow. This study used a PVN-centered strategy to investigate molecular changes after AMI, prioritize candidate molecules associated with VA, and assess whether related inflammatory and immune features are also present in AF cohorts. - Source: PubMed
Publication date: 2026/09/03
Wang WenlongZhao WenboChen YuranWang XinJi ChunruiSun JingmeiBai YuYang YuhangQu Xiufen - The effect of diet on genetic regulation in humans remains largely unexplored. Here, we investigate gene-diet interactions in a unique group of healthy individuals (N = 200) who alternate between omnivory and dietary restriction of animal products for religious reasons. Using longitudinal proteomic and genotype data, we identify diet-responsive cis-pQTLs and highlight regulatory effects on LBR and MSRA, proteins involved in cholesterol and methionine metabolism respectively. LBR-associated cis-pQTL rs74148404 colocalizes with obesity exclusively under dietary restriction, suggesting diet-dependent modulation of genetic risk. We also show that a diet-dependent cis-pQTL for metabolic regulator FGF21 colocalizes with eosinophil and platelet traits pointing to diet-sensitive immunometabolic signalling. By parallel profiling of a continuously omnivorous control group (N = 211), we uncover seasonally dynamic genetic regulation for proteins linked to apoptosis in immune system pathways (MAVS, CASP3, PDLIM7, IL12RB1), effects likely masked by animal product restriction. These findings reveal dynamic diet- and season-sensitive regulatory mechanisms with implications for precision nutrition and individualized disease prevention strategies, and underscore the need to integrate environmental context into genetic studies of health and disease. - Source: PubMed
Publication date: 2026/08/08
Simistiras AlexandrosBocher OzvanEmmanouil ChristinaSkoulakis AnargyrosGlentis StavrosScarmeas NikolaosZeggini EleftheriaRouskas KonstantinosDimas Antigone S - We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic response. - Source: PubMed
Pacheco AddisonRemalante-Rayco PatriciaHaroon NigilPoddubnyy DenisInman Robert D - The red-spotted grouper nervous necrosis virus (RGNNV) exhibits high pathogenicity in larval , yet the immune molecular mechanism remains unclear. Non-coding RNAs (ncRNAs) are vital in the host's immune responses during viral infection. However, there has been no study on ncRNA research for this species to date. We systematically identified 105 DE microRNAs (miRNAs), 157 DE long non-coding RNAs (lncRNAs) and 31 DE circular RNAs between the infection group and control group. Functional enrichment analysis revealed that these differentially expressed genes were significantly enriched in pathways associated with innate immune defense, inflammatory, and cell death, such as JAK-STAT signaling pathway, NF-κB signaling pathway, apoptosis, and necroptosis. Furthermore, the lncRNA-miRNA-mRNA interaction network involving miR-93 was constructed, which may represent a promising candidate therapy target for future investigations. This study presents the first comprehensive ncRNA transcriptome dataset of infected with RGNNV, identifies key antiviral defense and cell death-related genes and hub pathways, and thereby identifies miR-93-involved lncRNA-miRNA-mRNA network and key targeted genes () as hub molecular regulators in immune response of this species. - Source: PubMed
Publication date: 2026/08/12
Guo XiaoliGao ChengbinChen ZhangfanLu ShengWang LeiLi WenshengHe XinleiYang ChuanjunLi JianweiChen Songlin - Mendelian susceptibility to mycobacterial disease (MSMD) is a subset of inborn errors of immunity (IEIs) predisposing to clinical infections from less virulent mycobacterial species. Variants in 22 genes, particularly in IL-12Rβ1, have been identified that impair interferon-gamma (IFN-γ)-mediated immunity. We report a new rare MSMD patient with a homozygous variant who presented with severe and persistent ascites. - Source: PubMed
Publication date: 2026/08/25
Dolikhani MohammadrezaShakibamaram GhazalehRashtian ParisaSaberi MohammadReshadmanesh AzadehGhafaripour HosseinaliMoradian ElhamMahdaviani Seyed AlirezaBustamante Jacinta