Ask about this productRelated genes to: MCP3 antibody
- Gene:
- CCL7 NIH gene
- Name:
- C-C motif chemokine ligand 7
- Previous symbol:
- SCYA6, SCYA7
- Synonyms:
- MCP-3, NC28, FIC, MARC, MCP3
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-04
- Date modifiied:
- 2016-10-05
Related products to: MCP3 antibody
Related articles to: MCP3 antibody
- Intrahepatic cholangiocarcinoma (ICC) presents significant therapeutic challenges due to its late-stage diagnosis and inherent treatment resistance, resulting in dismal prognosis. While ferroptosis induction has emerged as a promising antitumor strategy, its clinical implementation in ICC has been impeded by poorly defined resistance mechanisms. Here, we systematically investigated the immunomodulatory role of the CXCL5/CXCR2 axis in governing ferroptosis susceptibility through dual mechanistical pathways. In vitro studies revealed that CXCL5/CXCR2 signaling confers ferroptosis resistance by transcriptional upregulation of prostaglandin-endoperoxide synthase 2 (PTGS2), which can serve as a functional regulatory factor for ferroptosis. Utilizing a tumor-immune co-culture platform, we further demonstrated that CXCL5/CXCR2 axis-driven recruitment of N2 tumor-associated neutrophils (TANs) orchestrates a protective microenvironment against ferroptosis. Intriguingly, PTGS2 enhances N2 TANs chemotaxis via CCL2 and CCL7, and the recruited N2 TANs subsequently activate the NF-κB/PTGS2 pathway, thereby establishing a synergistic positive feedback loop. Notably, combinatorial treatment with the CXCR2 antagonist SB225002 and ferroptosis inducer Erastin exhibited synergistic antitumor activity in preclinical ICC models. This study provides mechanistic insights into the ferroptosis-immune crosstalk and proposes a novel combinatorial therapeutic paradigm for overcoming treatment resistance in ICC. - Source: PubMed
Publication date: 2026/08/17
Ye ChanqiLin KefengYang ShuyaoZhang YanGao WenliChen JiaqiDong YingBai RuiTian YangWang MinghaoYuan ZhijunMa YuxiaoHe YuqinChen RuyinFu WenguangJiang QiLi QiongRuan Jian - Atrophic non-union is a significant clinical challenge associated with impaired early inflammation resolution and delayed osteogenesis. Although the osteoimmune microenvironment is critical for bone healing, the specific molecular mechanisms regulating this process require further elucidation. - Source: PubMed
Publication date: 2026/07/20
Zhong KaiShao YufeiZhou YuHuang ZengyiLiu Xing - Immune-resistant colorectal cancer (irCRC), represented by microsatellite stable/proficient mismatch repair (MSS/pMMR) tumors, responds poorly to immune checkpoint blockade (ICB). Here, we developed an ultrasound-targeted nanodroplet destruction (UTND) strategy combined with surface anti-PD-L1-decorated nanodroplets (PPP@P@map) to enhance ICB responsiveness in MSS colorectal cancer. In CT26 and CMT93 murine subcutaneous MSS colorectal cancer models, PPP@P@map combined with UTND markedly suppressed tumor growth compared with control treatments. Single-cell RNA sequencing identified CAF_Pi16 as a candidate therapy-associated cancer-associated fibroblast subset that showed a treatment-related increase after PPP@P@map + UTND, which was further supported by flow cytometry and multiplex immunofluorescence validation. Mechanistically, UTND induced oxidative stress in tumor cells and promoted the generation of advanced glycation end products (AGEs), which activated the AGE-RAGE/PKCα/NF-κB pathway in CAF_Pi16 and increased CCL7 secretion. CAF_Pi16-derived CCL7 provided a CCR2-dependent functional cue to CD8 T cells. In purified CD8 T cells, CCL7 activated NF-κB-related signalling, enhanced activation and cytotoxic effector features, and promoted NKG2D expression; these effects were attenuated by CCR2 blockade or NF-κB inhibition. Functionally, CCL7 enhanced CD8 T cell-mediated tumor-cell killing, whereas NKG2D blockade reduced this effect and weakened the antitumor efficacy of PPP@P@map + UTND in vivo. Together, these findings reveal a UTND-induced tumor cell-CAF_Pi16-CCL7-CD8+ T-cell signalling axis that enhances NKG2D-associated antitumor immunity and provides a mechanistic basis for further investigation of UTND-based strategies to improve ICB responsiveness in MSS/pMMR colorectal cancer. - Source: PubMed
Publication date: 2026/07/29
Tuo BaojingLi NaLiu SenboGao ShuochenLiu HangPei LipingGao XueyanLi KaiboXu YanxinSun ZhenqiangZhang YanLiu LinWang Chengzeng - Prostate cancer (PCa) is the most common malignancy in men. Recent evidence indicates a correlation between modulation of the tumor microenvironment, tumor growth and metastasis. Chemokines, including C-C chemokine ligand 2 (CCL2) and C-C chemokine ligand 7 (CCL7), participate in regulating inflammation, angiogenesis, and the recruitment of immunosuppressive cells. This study aimed to assess the diagnostic potential of serum CCL2 and CCL7 in patients with PCa, benign prostatic hyperplasia (BPH) and healthy controls. The study included 53 patients with PCa, divided into groups at low, intermediate, and high risk of disease progression, 55 with BPH, and 30 healthy controls. CCL2 and CCL7 concentrations were measured using a multiplex Luminex assay. Serum CCL7 concentration in PCa patients was significantly lower compared to controls. No significant differences in its concentration were found between PCa and BPH patients or between PCa subgroups at different risk levels. CCL7 demonstrated promising sensitivity (96.2%) and AUC (0.917). However, its ability to distinguish PCa from BPH was limited. CCL2 concentrations were significantly lower in the PCa group only compared to the BPH group. These results suggest that CCL7 may represent a potential adjunct marker within multimarker diagnostic strategies for prostate cancer, while CCL2 showed limited diagnostic utility. - Source: PubMed
Publication date: 2026/07/11
Sokólska WeronikaZajkowska MonikaNowiński Adam RafałOrywal Karolina - Intratumoral bacteria influence the progression and treatment response of solid tumors through multiple mechanisms. Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the head and neck; however, the role of intratumoral bacteria in OSCC initiation and progression remains poorly understood. - Source: PubMed
Publication date: 2026/07/21
Dong YunmeiChen KuichiZheng HongyaLiu WeiYan LiLuo ZhuoyanQin YuqiLv ShipingYang BingChen FangchunLiu YiyunPu JuncaiXie PengJi PingJin Xin