Ask about this productRelated genes to: MCP3 antibody
- Gene:
- CCL7 NIH gene
- Name:
- C-C motif chemokine ligand 7
- Previous symbol:
- SCYA6, SCYA7
- Synonyms:
- MCP-3, NC28, FIC, MARC, MCP3
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-04
- Date modifiied:
- 2016-10-05
Related products to: MCP3 antibody
Related articles to: MCP3 antibody
- Polymyalgia rheumatica (PMR), a chronic inflammatory disease that affects older people, is characterized by musculoskeletal pain in the shoulder, neck, and pelvic girdle. It can be challenging to discriminate PMR from older age onset rheumatoid arthritis (RA). Systematic investigations of serum proteins have been conducted to identify new biomarkers. However, few proteomic analyses have been conducted for PMR. We analyzed serum protein profiles to identify biomarkers of PMR in the comparison between PMR patients before corticosteroid treatment [PMR Tx(-)] and healthy controls (HCs). - Source: PubMed
Publication date: 2026/09/09
Furukawa HiroshiHikichi YuichiKunieda KoheiOka ShomiHiguchi TakashiTohma ShigetoItoh Kenji - Iodine-125 (I) seed therapy is recognized for treating abdominal solid tumors with minimal adjacent tissue damage but may induce radiation colitis when its implantation near colonic tissues, leading to a poor prognosis. Nevertheless, the underlying pathogenesis is not well understood. - Source: PubMed
Liu PingpingZeng XiongLiu WenjingXie HuichaoFang YongkunYang ErwanTang XiaoqiFan ChenglinChen Yihui - Sepsis, defined as life-threatening multi-organ dysfunction, remains a critical health challenge. Givinostat, an orally active histone deacetylase inhibitor with anti-inflammatory properties, has been approved for the treatment of Duchenne muscular dystrophy. However, its function in sepsis-induced myocardial dysfunction (SIMD) remains unclear. This study demonstrates that Givinostat significantly improves survival and attenuates cardiac injury in both cecal ligation and puncture (CLP) and lipopolysaccharide (LPS)-induced SIMD. Givinostat administration markedly alleviated SIMD-induced myocardial inflammation, oxidative stress, and cardiomyocyte apoptosis. Mechanistically, Givinostat suppressed macrophage infiltration into the heart, downregulated CCL7 expression in cardiac macrophages, and enhanced macrophage phagocytic activity. Crucially, the cardioprotective effects of Givinostat were abolished by recombinant CCL7 administration, underscoring a CCL7-dependent mechanism. These findings reveal that Givinostat alleviates SIMD by attenuating macrophage inflammation through suppression of the CCL7/CCR1 signaling pathway and restoration of phagocytic function, highlighting its therapeutic potential for sepsis and SIMD. - Source: PubMed
Publication date: 2026/09/13
Jian WentingDu MingchengMa HuigaiJiang MengbiZhong YuLong XiangJiang JingjingZhu GuohongGong YuanZhang Sheng - Glutaminyl-peptide cyclotransferase-like protein (QPCTL) is a pivotal post-translational modification enzyme remodeling tumor microenvironment through catalyzing the pyroglutamation (pGlu) at the N-terminus of CD47, CCL2 and CCL7. Inhibiting QPCTL attenuates the CD47-SIRPα interaction and impairs the recruitment of pro-tumoral macrophages, thereby promoting anti-tumor immunity, and has emerged as a potential target for cancer immunotherapy. Nevertheless, the development of QPCTL inhibitors for cancer immunotherapy is still in its early stages. Herein, we report the discovery and characterization of QP6126, a highly potent and orally bioavailable small-molecule QPCTL inhibitor (IC of 2.3 nM). Mechanistically, QP6126 effectively ablates the pGlu-CD47 modification, thereby abolishing CD47-SIRPα interaction, and sensitizing melanoma cells to macrophage-mediated phagocytosis. Notably, QP6126 displays significant in vivo antitumor efficacy in B16F10 melanoma mouse model following oral administration. This study establishes QP6126 as a promising candidate for clinical translation and validate QPCTL as a strategic target for diversifying cancer immunotherapy. - Source: PubMed
Publication date: 2026/09/07
Xie LongyanZheng ZeningZhang XindanSun YaoliangLiu SiqiXu ShilinYu Lei - Asthma is a complex, heterogeneous, and inflammatory disease with an increasing incidence worldwide. This study aimed to investigate the therapeutic mechanisms of sophocarpine in asthma systematically. - Source: PubMed
Publication date: 2026/08/24
Zhi WenbingZhang HongQiao ZiyaoJiang ShengnanLiang ZongsuoLiu Yang