Ask about this productRelated genes to: IL2Ra antibody
- Gene:
- IL2RA NIH gene
- Name:
- interleukin 2 receptor subunit alpha
- Previous symbol:
- IL2R, IDDM10
- Synonyms:
- CD25
- Chromosome:
- 10p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-01-22
- Date modifiied:
- 2019-04-23
Related products to: IL2Ra antibody
Related articles to: IL2Ra antibody
- Regulatory T cells (Tregs) prevent autoimmunity through suppressive functions largely programmed by the transcription factor FOXP3. Healthy humans express approximately equivalent levels of two major alternatively spliced isoforms of FOXP3: a full-length version containing all coding exons (FOXP3-FL) and a version lacking exon 2 (FOXP3-ΔE2). However, sole FOXP3-ΔE2 expression causes lethal IPEX syndrome, and the FOXP3-ΔE2 isoform is elevated in several autoimmune diseases. These observations strongly suggest defects in suppression by FOXP3-ΔE2 Tregs which we investigated here using Foxp3-ΔE2 mice. In an influenza virus infection model, Foxp3-ΔE2 mice had an increased magnitude of the CD8 T cell response during acute and memory formation phases of infection. Transcriptomic and chromatin accessibility analyses of homeostatic Foxp3-ΔE2 Tregs revealed impaired Treg programming, including reduced expression of inhibitory molecules such as and chemokine receptors. Decreased cell surface CD25 expression on Foxp3-ΔE2 Tregs was associated with reduced IL-2 responsiveness in Foxp3-ΔE2 Tregs and, reciprocally, increased IL-2 responsiveness in CD8 T cells from Foxp3-ΔE2 mice. Additionally, altered chemokine receptor expression resulted in diminished localization of Foxp3-ΔE2 Tregs to the T cell zone of the inflamed lymph node. Thus, Treg programming by the Foxp3-ΔE2 isoform impairs suppressive function, resulting in failure to restrain CD8 T cells and aberrant immune responses. - Source: PubMed
Publication date: 2026/04/23
Weinstein Kristin NBishop Zoe HShamskhou Elya ABarry Finnegan NChandrashekar HarshiniVerdezoto Gabrielade Leon MarissaAlbe Joseph RKoval AndrewZhou BaohuaDomeier Phillip PGerner Michael YCampbell DanielZiegler Steven F - Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a Th2 disease characterized by heterogeneous mast cell hyperplasia. We previously used transcriptomics to identify discrete gene expression linked with intraepithelial MCs expressing tryptase alone (MC), subepithelial MCs co-expressing tryptase and chymase (MCs), and immature MCs in CRSwNP. While MCs were the only subset consistently observed in both CRSwNP and control CRS donors without nasal polyposis (CRSsNP), the degree to which they differ across disease states remains unexplored. - Source: PubMed
Publication date: 2026/04/25
Santos Rizza USuber JadaDerakhshan TaherehNiharika Gullapalli Sri VidyaMatsuda KenshiroZawacki Mabel CLai JuyingBergmark Regan WLee Stella EMaxfield Alice ZRoditi Rachel EBaloh Carolyn HLaidlaw Tanya MBoyce Joshua ADwyer Daniel F - Gene expression in regulatory T cells (Tregs) is context-dependent and maintains peripheral immune homeostasis. FOXP3 is lineage defining but not sufficient for Treg function or persistence. To define the cell-intrinsic roles of the FOXP3 paralogs FOXP1 and FOXP4, we generated and studied mice with Treg-specific deletion of and/or . FOXP1 and FOXP4 are required to maintain the peripheral Treg pool through enhancing transcription, thereby promoting sustained high-level expression of IL-2Rα and thus of the high-affinity IL-2Rαβγ complex. Integrating RNA-seq and ATAC-seq with previously published ChIA-PET and publicly available data, we propose a model of transcriptional regulation in which in which FOXP1 and FOXP4 anchor chromatin looping of the locus in mature Tregs, augment super-enhancer activity, and drive sustained CD25 expression. Our results reveal a unique role of FOXP1, and to a lesser extent FOXP4, in controlling Treg homeostasis. - Source: PubMed
Publication date: 2026/04/17
Dong DachuanHigdon Lauren EZhou JiayanLin Jian-XinPadiapu JyothiKim YeslLeonard Warren JMaltzman Jonathan S - Crohn's disease (CD) and ulcerative colitis (UC) share common features of inflammation to a greater extent in children than in adults. However, histopathological scoring systems of mucosal inflammation are usually available only for either one of these entities. The IBD-DCA score is the first of its kind to incorporate both into one scoring system but still lacks validation in pediatric IBD. - Source: PubMed
Publication date: 2026/03/28
Schnell AlexanderWei XinyiBossenz JanManuilova IrynaChristoph JanAllabauer IdaClassen MerleRegensburger Adrian PWoelfle JoachimErber RamonaHoerning André - Primary central nervous system lymphoma (PCNSL) is a rare and aggressive B-cell lymphoma in which early diagnosis remains challenging. Although cerebrospinal fluid (CSF) B-cell-associated factors including soluble interleukin-2 receptor subunit alpha (IL-2RA) are known diagnostic markers, they often reflect neuroinflammation and are insufficient on their own to reliably differentiate PCNSL from neuroimmunological diseases. On the other hand, CSF immune checkpoint molecules reflect neuro-immune regulation and remain incompletely evaluated as biomarkers for PCNSL. We aimed to determine whether CSF immune checkpoint molecules can serve as additional diagnostic and prognostic biomarkers for PCNSL alongside B-cell-associated factors. - Source: PubMed
Publication date: 2026/04/02
Nishii ShotaAkatani RitsuShiroma KyokaTakeda RyosukeTsuji AsatoKatanazaka KimitakaMatoba KentoOtani MayumiKoto ShusukeTanaka KazuhiroNagashima HiroakiSekiguchi KenjiSasayama TakashiChihara Norio