Ask about this productRelated genes to: CD137 protein
- Gene:
- TNFRSF9 NIH gene
- Name:
- TNF receptor superfamily member 9
- Previous symbol:
- ILA
- Synonyms:
- CD137, 4-1BB
- Chromosome:
- 1p36.23
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-12
- Date modifiied:
- 2016-10-05
Related products to: CD137 protein
Related articles to: CD137 protein
- Patients with Sjögren's syndrome (SS) are at significantly increased risk of developing non-Hodgkin lymphoma (NHL). However, effective biomarkers to identify the subgroup of SS patients who will progress to lymphoma are currently lacking. This study aims to elucidate the causal mechanisms linking SS to NHL and to identify circulating inflammatory protein biomarkers for risk stratification. - Source: PubMed
Publication date: 2026/04/08
Wang HongyeYan HelinYang MifengZhang YingyiZhang JiaZhouyang MengqianZhao Bo - Lichen planus (LP) is a chronic inflammatory disease of the skin and mucous membranes, marked by T cell infiltration and keratinocyte apoptosis. However, its immune microenvironment remains poorly understood. Using single-cell RNA sequencing, spatial transcriptomics, and proteomics on samples from 28 patients and 18 healthy controls, we identify elevated interferon (IFN) and cytotoxic signatures in CXCL13CD8 T cells in both cutaneous and mucosal LP, but not in lichen planopilaris. T cells expressing TNF and IFNG are spatially linked to epithelial cells through ligand-receptor interactions, correlating with inflammation. We identify cDC2A cells as key contributors, proximal to CXCL13CD8 T cells, serving as a major source of IL-15. CXCL13CD8 T cells express TNFRSF9 (4-1BB), which enhances their cytotoxic responses in the skin. In summary, our data reveal a critical role for cDC2A in driving CXCL13CD8 T-epithelial cytotoxicity in cutaneous and mucosal LP through TNFRSF9. - Source: PubMed
Publication date: 2026/03/14
Jiang RundongBogle RachaelXing XianyingKirma JosephFox JenniferHarms Paul WDo TranBilli Allison CKahlenberg J MichelleModlin Robert LTeles RosaneWest JulieMangold AaronZhang HaihanSchneider Martin ABruno SandroRoediger BenMartiny-Baron GeorgTsoi Lam CHacini-Rachinel FerielRöhn Till AGudjonsson Johann E - Previous investigations have shown that the absence of typical breast symptoms is associated with unfavorable outcomes after an acute myocardial infarction (AMI). Delayed diagnosis and therapy could not explain these results, so other causes seem to be involved. Therefore, in the present analysis the association between inflammatory plasma proteins and typical chest pain symptoms in hospitalized patients with acute ST-elevation myocardial infarction (STEMI) was investigated. - Source: PubMed
Publication date: 2026/03/11
Wolfermann SophiaSchmitz TimoRaake PhilipLinseisen JakobMeisinger Christa - Inflammatory responses are characterized by the activation of immune cells, while inflammatory biomarkers intricately interact with the immune system. While experimental studies have provided important mechanistic insights, large community-based investigations jointly profiling immune cell phenotypes and inflammatory biomarkers remain limited. This study aims to investigate the association between circulating immune cell phenotypes and inflammatory protein biomarkers in the Framingham Heart Study Offspring cohort. A sample of 873 dementia-free participants (52% female, mean age 61) had extensive profiling of peripheral blood mononuclear cells and inflammatory plasma protein biomarkers (OLINK Proteomics) collected at Offspring Exam 7 (the seventh examination cycle of the cohort, 1998 to 2001). Among cross-sectional pairwise associations between 77 immune cell phenotypes and 68 inflammatory biomarkers, CD8 naïve T cells showed negative associations with multiple inflammatory proteins, including CD40, CD5, CXCL9, CXCL10, IL8, OPG, TGF-alpha, TNF, TNFRSF9, and 4E-BP1. Higher levels of CD8 Cytotoxic T cells, CD8 + CD27-, CD8 effector T cells, and interferon gamma-producing CD8 T cells (Tc1) were all associated with higher levels of soluble CD8 alpha chain (CD8A). In contrast, CD4/CD8 T cell ratio, Immunoglobulin D (IgD)-expressing B cells and naïve Immunoglobulin D and Immunoglobulin M double-positive B cells (IgD + IgM + B cells) were associated with lower CD8A. Stratified analyses revealed significant associations primarily in males and participants over 60. These findings provide a comprehensive population-level characterization of the relationships between circulating immune cell phenotypes and inflammatory biomarkers in a well-defined community-based cohort, offering insight into immune cell-inflammatory profiles associated with aging. - Source: PubMed
Publication date: 2026/02/27
Chen JiachenDoyle Margaret FCao YumengIyer SandhyaRagab Ahmed A YMurabito Joanne MLunetta Kathryn L - Previous studies have found that circulating inflammatory proteins may play an essential role in the occurrence and development of neuropathic pain. However, the majority of existing evidence is derived from observational studies, which are prone to confounding factors and reverse causality, and the inflammatory profiles associated with different types of neuropathic pain remain poorly understood. Consequently, more robust methodologies are urgently required to elucidate the causal relationships between these variables. Therefore, a bidirectional Mendelian randomization analysis was performed to assess the causal relationship between inflammatory proteins and neuropathic pain, specifically focusing on neuralgia and neuritis, including glossopharyngeal neuralgia, phantom limb syndrome with pain,small fiber neuropathy, and unspecified neuralgia. - Source: PubMed
Publication date: 2026/02/17
Zhong JiajunLi HuanminHuang ChongboZhang PengfeiPang XiaoyuLuo ZimengLi Chunguang