Ask about this productRelated genes to: TAFA2 protein
- Gene:
- TAFA2 NIH gene
- Name:
- TAFA chemokine like family member 2
- Previous symbol:
- FAM19A2
- Synonyms:
- TAFA-2
- Chromosome:
- 12q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-17
- Date modifiied:
- 2019-01-14
Related products to: TAFA2 protein
Related articles to: TAFA2 protein
- To investigate the genetic relationships and domestication status of Hainan meat pigeon populations, whole-genome sequencing was performed on 70 individuals across seven breeds: Shiqi (SQ), Silver King (SK), Shenwang (SW), Dabao (DB), Tianxiang No.1 (TX), Hybrid King (HK), and White Carneau (WC), with each breed represented by 10 individuals (5 males and 5 females). From 824 Gb of high-quality sequencing data, we identified 13,347,452 high-confidence single nucleotide polymorphisms (SNPs). Population structure analysis revealed divergent genetic clustering: WC, DB, TX, and HK individuals demonstrated extensive genomic admixture, while SK, SQ, and SW breeds formed distinct clusters with minimal interbreed genetic exchange. Selective sweep analysis highlighted genes under strong positive selection (TAFA2, FNDC3B, TFAP2B, PDCL3, EPC1 and LHX2). Functional annotation linked TAFA2 to accelerated growth in SK pigeons through muscle development modulation. The genes FNDC3B and TFAP2B were associated with fat deposition capacity in SQ pigeons. Concurrently, PDCL3, NEK6, LHX2, and EPC1 were implicated in SW pigeons' large body size and superior production traits. This study provides the first genomic compendium for Hainan meat pigeons, delineating their genetic diversity, adaptive evolution, and domestication patterns. The identified selection signatures establish a foundation for precision breeding strategies targeting growth, reproduction, and climate resilience in commercial pigeon production. - Source: PubMed
Publication date: 2025/08/25
Xu ZixinXu TieshanGuo ShunBai DingpingZhang LiSun YayaXia WenpengLiu YutingXue MengruGu Lihong - Liver injury, a common pathophysiological basis of various liver diseases, is associated with inflammation. Hepatic nerves regulate inflammation. However, the specific signals that trigger inflammation and methods to treat inflammation by targeting nerves remain unknown. - Source: PubMed
Publication date: 2025/03/07
Zhou XiMa ZhiboCheng QiJiang NaLi JunboZhan TianaoYuan NaonaoChen YanyuWang LuWang JingzengLi QingwenJia WenlongXie BowenZhao YuanyuanZhang BoYang BoDai ChenWei LaiLiu JingChen ZhishuiLan Peixiang - TAFA2, a cytokine specifically expressed in the central nervous system, plays a vital role in neuronal cell survival. TAFA2 deficiency has been correlated to various neurological disorders in mice and humans. However, the underlying mechanism remains elusive, especially its membrane-binding receptor through which TAFA2 functions. This study aimed to identify the specific binding receptor responsible for the anti-apoptotic effects of TAFA2. - Source: PubMed
Publication date: 2023/11/07
Liang HuiTang Ling YunGe Hao YangChen Ming MeiLu Shun YuanZhang Hong XinShen Chun LingShen YanFei JianWang Zhu Gang - TAFA chemokine like family member 4 (TAFA4, also named FAM19A4) is a member of the TAFA chemokine like ligand or FAM19A family, which includes TAFA1, TAFA2, TAFA3, TAFA4, and TAFA5 (or FAM19A1, FAM19A2, FAM19A3, FAM19A4, and FAM19A5). They are also referred to as neurokines and are involved in the regulation of a diverse range of cellular processes, including chemotaxis of macrophages, phagocytosis, and release of reactive oxygen species (ROS). TAFA4 is a marker of C-low-threshold mechanoreceptors and is expressed predominantly in nociceptors, such as dorsal root ganglia (DRG). TAFA4 has been implicated in the sensory perception of pain in the spinal cord. Mice with deficiency of TAFA4 demonstrate altered excitability in lamina IIi neurons in DRG in addition to increased mechanical and chemical nociception following inflammation or injury. As a secreted protein, TAFA4 binds to cell surface receptor formyl peptide receptor 1 (FPR1), a G protein-coupled receptor to mediate the chemoattraction of macrophages, phagocytosis, and the inflammatory profile of macrophages. It also interacts with cell surface neurexin to mediate signalling across the synapse. Further understanding the mechanisms by which this conserved protein family regulates diverse biological processes such as in neuronal functions, inflammation, and tissue fibrosis will help to design therapeutic targets for the treatment of TAFA related diseases such as spinal cord injury and neuro-inflammatory disorders. - Source: PubMed
Publication date: 2022/05/31
Zhu SipinHu XiaoyongBennett SamuelMai YuliangXu Jiake - Exacerbation of asthma is affected by genetic and environmental factors, but little is known about genetic differences according to smoking status. We evaluated genetic factors associated with asthma exacerbations in smokers and non-smokers, and identified the underlying mechanisms via a genome-wide association study (GWAS) and gene-level analyses according to smoking status. - Source: PubMed
Publication date: 2022/05/17
Son Ji-HyePark Jong-SookLee Jong-UkKim Min KyungMin Sun-AhPark Choon-SikChang Hun Soo