Ask about this productRelated genes to: ITAC protein
- Gene:
- SDCBP2 NIH gene
- Name:
- syndecan binding protein 2
- Previous symbol:
- -
- Synonyms:
- ST-2, SITAC18
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-17
- Date modifiied:
- 2015-12-16
Related products to: ITAC protein
Related articles to: ITAC protein
- Lung adenocarcinoma (LUAD) is a global health threat due to its rapid malignant progression and poor prognosis. Ferroptosis plays a key role in LAUD progression, but the critical ferroptosis-related factors in LUAD have not been further explored. The aim of this work was to explore novel ferroptosis-related therapeutic targets and prognostic biomarkers for LUAD. - Source: PubMed
Publication date: 2025/12/02
Sun ShaowuGu ZhuoyuYuan ShuangZhang KaishangLiu WeiWei ZhengpanFan WenboWang ZelongZhao TianliangTang MingboGao XinliangZhang GuoqingLi XiangnanPan Xue - This study investigated the effects of dietary chitosan oligosaccharide (COS) in sows on the reproductive performance and milk composition of sows, as well as the intestinal growth and development of piglets. A total of forty pregnant sows (average parity = 4) at day 90 of gestation were randomly divided into two groups and fed a basal diet (CONm, = 20) or a diet supplemented with 100 mg/kg COS (COSm, = 20) from late gestation to lactation. At 24 days of age, a 2 × 2 factorial treatment arrangement was employed with two independent factors: the sow diet and the piglet diet. The piglets selected from the same litter of sows fed CONm or COSm were assigned to receive either a control diet (CONp, = 6) or a diet containing 100 mg/kg COS (COSp, = 6) for 14 days. Maternal COS supplementation shortened the weaning-to-estrus interval and improved milk composition, up-regulated jejunal mRNA expressions of , , , , and , ileal concentrations of IL-10 and IFN-γ in 2-days old suckling piglets ( < 0.05); and enhanced plasma TG level, jejunal mRNA expressions of and , ileal concentrations of IL-10 and mRNA expressions in 24-days old suckling piglets ( < 0.05). In 38-days old weaning piglets, maternal COS enhanced the ratio of spp., butyrate, and propionate concentrations in cecal digesta, as well as decreased the concentrations of IL-10 and IFN-γ in ileal mucosa ( < 0.05), and the concentration of ( < 0.05) in cecal digesta. Meanwhile, COS supplementation in weaned piglets increased the jejunal mRNA level of , and cecal acetate, propionate, and total SCFA contents ( < 0.05). There were interaction effects between dietary COS in sow and dietary COS in piglet on ileal density, jejunal crypt depth and jejunal expression ( < 0.05). These results indicated that maternal COS intervention can enhance the reproductive performance and milk composition in sows, while improving intestinal growth and immunity parameters of suckling piglets. Furthermore, supplementing both sows and piglets with COS appeared to be a more effective way to promote gut growth in weaning piglets. - Source: PubMed
Publication date: 2025/09/23
Fang TingtingYao YingTian GangZheng PingYu JieYan HuiPu JunningYu Bing - Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy that lacks reliable biomarkers to guide treatment decisions. Effective prognostic tools are needed to improve its clinical management. We conducted a comprehensive proteomic analysis on 115 PDA patient samples with matched adjacent normal tissue. A 20-protein diagnostic panel was identified (LGALS1, ANXA2, LGALS3BP, CTSD, S100P, COL12A1, SFN, THBS2, CTHRC1, THBS1, SERPINB5, LAMC2, POSTN, CEACAM6, CTSE, PLEC, PKM, S100A11, TAGLN2, ALDOA). Consensus clustering analysis identified four prognostic proteomic subtypes. Subtypes with poorer prognoses exhibited upregulation of neutrophil degranulation, extracellular matrix remodeling, focal adhesion, Mesenchymal Epithelial Transition, collagen formation, and PI3K-Akt-mTOR-related pathways, indicating a predominance of basal-like and activated stromal features. In tumors with homologous recombination deficiency or Catalogue of Somatic Mutations in Cancer Signature-3, several immune-related proteins were enriched. An 18-protein (PURB, SDCBP2, CD2BP2, GALM, SERPINA3, OAS3, FAN1, ZPR1, KRT2, NUDT2, SMNDC1, SERPINA4, CUTA, WDR36, POSTN, CLEC11A, PEX14, and PI4KA) risk score was developed and validated using multicox regression analyses with LASSO regularization. The risk score demonstrated independent prognostic significance for overall survival and recurrence, and was validated in an independent proteomic dataset generated using a different proteomic technology. This study thus introduces four novel prognostic PDA subtypes, and an 18-protein risk score validated in an independent dataset, which shows promise for improving survival prediction and could serve as a valuable tool for personalized treatment guidance. - Source: PubMed
Aref Adel TGrealey JasonPathan MohashinNoor ZainabAnees AsimAzad A K MSmith Daniela LeeHumphries Erin MBucio-Noble DanielKoh Jennifer M SSykes Erin KWilliams Steven GLyons Ruth JLucas NatashaXavier DylanSahni SumitMittal AnubhavSamra Jaswinder SPearson John VWaddell NicolaKondrashova OlgaChou AngelaSioson LorettaSheen Amy Hains Peter GRobinson Phillip JZhong QingReddel Roger RGill Anthony J - Regenerative processes occur at various levels in all organisms, yet their complexity continues to raise new questions about their mechanisms. It has been demonstrated that small extracellular vesicles (sEVs), secreted by all cells and influencing their function, play a significant role in regeneration. In the context of regenerative processes, oral mucosal tissues consistently receive interest, as they are among the most rapidly healing tissues in the human body. In this study, we utilized spatial transcriptomics to map gene expression to specific spatial locations within the gingiva tissue section, using publicly available transcriptomic data. This analysis revealed new insights into this tissue and the biogenesis of sEVs within it. The identified clusters encompassed two main regions-the epithelium and lamina propria-as well as minor niches within them. Using Gene Ontology (GO) analysis, we identified two clusters most enriched in extracellular vesicle-related GO processes. These included the superficial and deeper layers of the sulcular epithelium, one of the most peripheral regions of the gingiva. Of the 43 genes identified in the literature as having a potential or documented role in sEVs biogenesis, 12 were selected for further analysis. , , and showed clear specificity and the highest expression in the superficial layer of the sulcular epithelium. also exhibited high expression in this layer, though its levels were comparable to the outer layer of the oral epithelium. Other well-established sEVs marker genes, such as , , , , , , , and , were also expressed in the examined tissue; however, their expression was not specifically exclusive to the sulcular epithelium. Our study is the first to perform a meta-analysis of available gingival transcriptomic data in the specific context of sEVs biogenesis. The presented data and conclusions provide new insights into the role of different structures within healthy human gingiva and shed new light on both known and potential markers of sEVs biogenesis. These findings may contribute to the development of regeneration-targeted research, especially on oral tissues. - Source: PubMed
Publication date: 2025/04/07
Borowiec Blanka MariaBlatkiewicz MałgorzataDyszkiewicz-Konwińska MartaBukowska DorotaKempisty BartoszRuciński MarcinNowicki MichałBudna-Tukan Joanna - Numerous long noncoding RNAs (lncRNAs) have been proven to participate in osteogenesis and postmenopausal osteoporosis (PMOP). We measured serum SDCBP2-AS1 expression changes in patients with PMOP and investigated its effects on osteoblast differentiation in human bone marrow-derived mesenchymal stem cells (hBMSC) cells. - Source: PubMed
Publication date: 2025/07/10
Chen JindongZhang ShilongCai DixinYin QingXie QianXu PengfangZhu Junling