Ask about this productRelated genes to: TECK protein
- Gene:
- CCL25 NIH gene
- Name:
- C-C motif chemokine ligand 25
- Previous symbol:
- SCYA25
- Synonyms:
- TECK, Ckb15
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-14
- Date modifiied:
- 2016-03-01
Related products to: TECK protein
Related articles to: TECK protein
- Tuft cells are a rare type of epithelial cell that are essential to regulate innate and adaptive immune responses. Mucosal immunity is also composed primarily of IgA produced by B cells that is secreted onto mucosal surfaces as secretory IgA via the polymeric immunoglobulin receptor (pIgR). The homing of B cells in lymphoid organs is mediated by certain adhesion receptors, such as α4β7 and chemokine receptor 9 (CCR9), that bind to the specific vascular ligands, mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) and chemokine ligand 25 (CCL25), respectively. It is unclear whether tuft cells, MAdCAM-1, CCL25, and pIgR are present or expressed in the nasal cavities of pigs. Our study aimed to develop immunohistochemistry (IHC) or immunofluorescence (IF) staining for the detection of tuft cells, MAdCAM-1, CCL25, pIgR, and IgA- or IgG-positive cells in porcine nasal turbinates. The tissues were acquired from the piglets of two different treatment groups in our previous studies that investigated the impact of oral vitamin A supplementation (VA) on the maternal immunity of vitamin A-deficient (VAD) sows and the passive protection of their piglets against rotavirus A (RVA): (1) VAD + VA + RVA and (2) VAD + RVA piglets. Our IHC staining revealed that low numbers of advillin-positive, bottle-shaped cells that morphologically resemble tuft cells were present in the mucosal epithelium and the mucous duct or glands. There were also moderate to large amounts of MAdCAM-1 and CCL25 in the endothelial cells lining the vascular structures present in the lamina propria of nasal turbinates and moderate to large amounts of pIgR in the turbinate mucosal epithelium. Moderate to high numbers of IgA- or IgG-positive cells were present in the lamina propria. There were no differences in IF- or IHC-positive scores or the positive cell numbers of all parameters tested between VAD + VA + RVA and VAD + RVA piglets, suggesting little or no effect of VA on the parameters tested. Our study demonstrated the use of IHC/IF staining methods for the detection of tuft cells, MAdCAM-1, CCL25, pIgR, and IgA- or IgG-positive cells in porcine nasal turbinates, expanding our understanding of the in situ distribution and comparison in the nasal cavity of pigs born to the sows fed vitamin A-deficient diets with or without vitamin A supplementation. - Source: PubMed
Publication date: 2026/09/18
Jung KwonilVlasova Anastasia NSaif Linda J - - Source: PubMed
Publication date: 2026/09/18
- To investigate the potential causal effects of six circulating inflammatory proteins on lung adenocarcinoma risk using Mendelian randomization. - Source: PubMed
Publication date: 2026/08/05
Tan HeyiMa ShirongLiu Yi - Lymphocyte recruitment to inflamed intestines in inflammatory bowel disease (IBD) critically depends on shearstress-regulated integrin αβ/MAdCAM-1 interactions. However, the mechano-chemical coupling between the chemokine CCL25 and the intracellular adaptor Kindlin-3 in activating αβ under physiological flow remains unclear. - Source: PubMed
Publication date: 2026/08/08
Zhuo PaiminLuo ZhiqingLuo XianwenWang HefengDong ChengLi Quhuan - Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disease associated with increased cardiovascular risk, yet the mechanisms linking AD to atherosclerosis and clinically relevant biomarkers of early vascular involvement remain poorly defined. We characterized the circulating proteomic profile of moderate-to-severe AD and identified biomarkers associated with subclinical atherosclerosis. In this cross-sectional study, serum samples from patients with AD (n=34), psoriasis (n=34), and healthy controls (n=20) were analyzed using proteomic panels targeting inflammatory and cardiovascular pathways. Participants underwent carotid and femoral ultrasound to detect atheromatous plaques. Compared with controls, AD showed increased circulating Th2 (CCL13, ST2, IL-13), innate (IL-6, IL-18), Th1 (IFN-γ), and Th17 (IL-17RA) markers, together with cardiovascular-related proteins including CCL19, FGF21, HGF, and P-selectin, with enrichment of atherosclerosis-related pathways. In AD, plaques were associated with higher LDL receptor, CDH5, transferrin receptor, CCL19, and CCL25, and lower IGFBP-2 levels, which also correlated with atherosclerosis burden. A composite proteomic score showed good discrimination of plaques (AUC 0.94) and outperformed traditional cardiovascular risk factors. Proteomic profiles and plaque-associated proteins differed markedly from psoriasis. These findings identify a disease-specific systemic proteomic signature in AD linked to early atherosclerosis and highlight circulating biomarkers with potential relevance for cardiovascular risk stratification. - Source: PubMed
Publication date: 2026/09/09
Berna-Rico EmilioNeria FernandoGómez-de la Fuente EnriquePérez-García BibianaAranda Carlos JAbbad-Jaime de Aragón CarlotaPerez-Bootello JavierDomínguez-López RaquelMonge DianaDavo-Mogica MariaBlauvelt AndrewGonzález-Cantero Álvaro