Ask about this productRelated genes to: IL17F protein
- Gene:
- IL17F NIH gene
- Name:
- interleukin 17F
- Previous symbol:
- -
- Synonyms:
- IL-17F, ML-1, ML1
- Chromosome:
- 6p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-03-18
- Date modifiied:
- 2019-04-23
Related products to: IL17F protein
Related articles to: IL17F protein
- 2-year safety and efficacy of bimekizumab, a dual IL-17A and IL-17F inhibitor, has been demonstrated across the full disease spectrum of axial spondyloarthritis (axSpA). We report bimekizumab long-term safety and efficacy over 3 years. - Source: PubMed
Publication date: 2026/06/15
Baraliakos XenofonDeodhar Atulvan der Heijde DésiréeVan den Bosch FilipMagrey MarinaMaksymowych Walter PTomita TetsuyaXu HujiCoarse JasonPrajapati ChetanManente MyriamMarten AlexanderGensler Lianne S - Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans-kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In , EVs contribute to parasite survival, host-pathogen interactions, and immune modulation. In this study, EVs were isolated from trophozoites grown in two serum-free media of distinct nutritional complexity (TYI-33 and DMEM) and characterized to define their molecular composition, pathogenic potential, and immunogenic properties. Nanoparticle tracking analysis showed vesicles predominantly 51-150 nm in diameter. Proteomic profiling identified 227 proteins in TYI-33 EVs and 97 in DMEM EVs, including molecules involved in metabolism, antioxidant defence, and virulence. Among these, giardipains 1-3, enolase, fructose-bisphosphate aldolase, ornithine carbamoyltransferase, and arginine deiminase were detected. TYI-33 EVs induced disruption of epithelial junctions and apoptotic-like changes in IEC-6 monolayers, consistent with contact-independent cytopathic activity. To assess their immunoprotective capacity, gerbils were intranasally immunized with TYI-33 EVs and challenged with . Immunized animals showed significant reductions in intestinal trophozoite burden and faecal cyst shedding at 7, 14, and 21 days post-infection, accompanied by increased serum IL-17F and IL-22. Collectively, these findings indicate that EVs, while carrying virulence-associated factors, also possess strong immunogenic properties, supporting their potential as a novel mucosal vaccine platform against giardiasis. - Source: PubMed
Publication date: 2026/06/11
Gerardo Corral-RuizRaúl Argüello-GarcíaDalia Ortiz-LozanoLizbeth Salazar-VillatoroOnam Pech-Santiago EdarMartha Espinosa-CantellanoDaniel Hernández-CuetoAngélica Silva-Olivares DAbigail BetanzosGuadalupe Ortega-Pierres M - : GG (LGG) is one of the most widely utilized probiotic strains with a variety of biological functions including prevention and treatment of gastro-intestinal infections and regulation of immune responses. : Here, we explored the role of LGG in regulating the differentiation of naïve CD4 T cells and its effect on alleviating the dextran sulfate sodium (DSS)-induced colitis in mice. : In vitro, we showed that LGG-derived metabolites not only promoted the differentiation of naive CD4 T cells into T-helper 17 cells (Th17 cells), but also selectively upregulated the expression of lactate-specific transporter solute carrier family 5 member 12 (SLC5A12). Interestingly, we manipulated a CD4 T cell-monocytes co-culture and found that heated LGG-loaded monocytes modulate naive CD4 T cells to differentiate preferentially into Treg cells rather than Th17 cells. To explain the above-mentioned contradiction, we used an experimental colitis model and found that LGG administration alleviated the DSS-induced colitis in mice, as indicated by decreases in weight loss and disease activity index. Moreover, SLC5A12 blockade (using a specific antibody) further reduced the colonic histological inflammatory score and decreased secretion of proinflammatory cytokines such as IFN-γ, IL-6, IL-17F, and IL-21. Notably, SLC5A12 blockade abolished the LGG-induced differentiation of the IL-17CD4 T (Th17) cells but significantly increased the frequency of Foxp3CD4 T (Treg) cells in the colonic lamina propria. Furthermore, a higher intracellular lactate concentration was observed in the colonic CD4 T cells isolated from the LGG-treated colitic mice compared with other groups. Additionally, we also found elevated levels of oxidative stress indicators such as MDA and HO, as well as excessive reactive oxygen species (ROS) in colonic tissue of DSS-treated only mice, while LGG can scavenge ROS by inducing nuclear factor-erythroid 2-related factor 2 (Nrf2) expression in enterocytes. : Altogether, these results indicate that LGG might alleviate preclinical colitis by modulating the Th17/Treg balance, and SLC5A12 blockade appears to enhance the anti-inflammatory properties of LGG. - Source: PubMed
Publication date: 2026/05/28
Zhang YilingHe XianghongZhao QianDuan QimingLi HepingQin RuiZuo WeifangXie KunhongHan Bo - : Palmoplantar psoriasis (PP) is a challenging variant of psoriasis that affects high-impact areas such as palms and soles and significantly impairs quality of life despite often limited body surface involvement. Conventional topical and systemic therapies may be insufficient, and evidence on biologic treatments for this specific phenotype remains limited. Bimekizumab (BKZ), a monoclonal antibody targeting IL-17A and IL-17F, has shown high efficacy in plaque psoriasis. This study aimed to evaluate the real-world effectiveness and rapidity of action of BKZ in patients with palmoplantar psoriasis compared with patients with psoriasis vulgaris (PV). : We conducted a multicenter retrospective cohort study using data from 22 Italian dermatological units within the IL-PSO (Italian Landscape-Psoriasis) database. Adult patients treated with BKZ between November 2022 and October 2024 were included and categorized into three groups: isolated PP, PP associated with PV (PP + PV), and PV without palmoplantar involvement. Clinical outcomes included the Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), and pruritus Visual Analogue Scale (VAS). Outcomes were assessed at baseline, week 4, and week 16. : A total of 47 patients were included. The baseline PASI was lower in the PP group compared with the PP + PV and PV groups, whereas the DLQI was highest in patients with isolated PP. Rapid clinical improvement was observed in all groups. The mean % PASI reduction at week 4 was 60.5%, 65.1%, and 77.0% in the PP, PP + PV, and PV groups, respectively, increasing to 94.8%, 90.4%, and 91.8% at week 16. The proportion of patients achieving complete clearance (PASI = 0) at week 16 was 73.3% (11/15), 68.2% (15/22), and 70.0% (7/10), respectively. Significant improvements were also observed in DLQI and pruritus scores over time. No significant safety concerns emerged. : In this real-world multicenter cohort, bimekizumab demonstrated rapid and high efficacy in patients with palmoplantar psoriasis, both isolated and associated with psoriasis vulgaris. These findings support the use of BKZ as an effective therapeutic option for psoriasis involving high-impact areas, as the palmoplantar, although larger studies are needed to confirm these results. - Source: PubMed
Publication date: 2026/05/28
Burlando MartinaSacchelli LidiaBettacchi AlbertaBrunasso Vernetti Giovanna AlexandraCaccavale StefanoBalato AnnaCagni Anna ElisabettaChersi KarinConti AndreaCostanzo AntonioD'amico DomenicoDe Simone ClaraDi Lernia VitoEsposito MariaGiofre' ClaudiaGisondi PaoloGraziola FrancescaLembo SerenaLicciardello MatteoLoconsole FrancescoMalagoli PiergiorgioSatolli FrancescaSusi Maria ElenaStrippoli DavideCozzani Emanuele Claudio - Indigenous chicken breeds in Bangladesh represent valuable genetic resources with resilience to infectious diseases; however, their breed-specific immune responses remain poorly defined. This study investigated cytokine-mediated immune responses in three native Bangladeshi chicken breeds (Deshi, Naked Neck, and Hilly) and one exotic commercial crossbred line, Sonali (widely used in Bangladesh), following experimental infection with 70,000 sporulated Eimeria tenella oocysts. Quantitative PCR was used to evaluate temporal expression of key cytokines (IL-2, IFN-γ, IL-12, IL-17A, IL-17F, IL-22, IL-10, TGF-β) and immune regulators (TLR-4, TLR-15, CTLA-4) at 6, 10, and 14 days post-infection (DPI), which corresponded to early invasion, active schizogony, and later stages involving repeated parasite life cycles. Distinct breed-specific immune patterns were observed. Deshi chickens exhibited a Th17-dominant response supported by Th1 activation, characterized by strong upregulation of IL-17A and IFN-γ at 14 DPI, along with balanced IL-10 expression, suggesting effective immune regulation and parasite clearance. Sonali chickens showed pronounced activation of innate immune receptors, particularly TLR-4 and CTLA-4, indicating strong early immune activation with variable cytokine modulation. Naked Neck chickens demonstrated moderate and balanced cytokine responses, while Hilly chickens exhibited dysregulated immune signaling, characterized by suppressed TLR-4 expression and elevated IL-12 levels, suggesting susceptibility to immune imbalance. Correlation and multivariate analyses revealed coordinated activation of Th1 and Th17 pathways and highlighted interactions between pro-inflammatory and regulatory cytokines. Principal component analysis clearly differentiated breeds based on cytokine expression profiles, indicating distinct immunological trajectories. These findings emphasize the importance of indigenous chicken breeds as genetic resources for disease resistance and provide insights for developing sustainable, breed-based poultry health strategies. To our knowledge, this is the first study to characterize breed-specific cytokine-mediated immune responses to E. tenella infection in indigenous chickens of Bangladesh. - Source: PubMed
Publication date: 2026/06/09
Ashikuzzaman MdRahman Md AfazurTarak Al NurSohan MohammadShahiduzzaman Md