Ask about this productRelated genes to: IL17F protein
- Gene:
- IL17F NIH gene
- Name:
- interleukin 17F
- Previous symbol:
- -
- Synonyms:
- IL-17F, ML-1, ML1
- Chromosome:
- 6p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-03-18
- Date modifiied:
- 2019-04-23
Related products to: IL17F protein
Related articles to: IL17F protein
- Single nucleotide polymorphisms (SNPs) in the interleukin-17F (IL-17F) gene may modulate inflammatory responses, with distinct effects on inflammation and tumour progression. Helicobacter pylori infection, a Group 1 carcinogen, is strongly associated with gastric cancer (GC) development. This study investigated the influence of IL-17F SNPs rs763780 (T>C), rs2397084 (T>C), rs9382084 (G>T), and rs12203582 (G>A) on GC susceptibility, considering H. pylori infection status. A total of 301 gastric biopsy samples were classified into the control (n = 95), gastritis (n = 112), and cancer (n = 94) groups. Helicobacter pylori detection and SNP genotyping were performed by quantitative real-time PCR (qPCR). Statistical analyses included Hardy-Weinberg equilibrium (HWE), Fisher's exact test, haplotype analysis, and genetic models using the SNPStats software, with sensitivity analysis performed in G*Power. All SNPs conformed to HWE except for rs763780. The T/C genotype and C allele of rs763780 were more frequent in the control group, indicating a protective effect (OR = 0.35; 95% CI = 0.14-0.91; p = 0.04). In contrast, the G/G genotype of rs9382084 (OR = 2.29; 95% CI = 1.02-5.13; p = 0.039) and the A/A genotype of rs12203582 (OR = 3.01; 95% CI = 1.01-8.93; p = 0.047) were associated with increased GC risk. No significant association was found for rs2397084. Haplotype analysis identified the rs763780-C/rs2397084-T/rs9382084-T/rs12203582-G haplotype as protective against GC (OR = 0.30; 95% CI = 0.10-0.86; p = 0.026). Stratified analysis according to H. pylori infection status suggested specific associations between SNPs rs763780, rs2397084, and rs12203582 and the risk of GC. These findings suggest that IL-17F gene SNPs influence GC susceptibility, exerting protective or risk effects depending on the specific polymorphism and its interaction with H. pylori infection. - Source: PubMed
Publication date: 2026/09/17
Nagahara MikaelaFredi Bruno MariBrandt Fabricio AbdallaFonseca Alanis Dos SantosCoelho Milena MilaniGirolli DanielliChen Elizabeth SuchiBarbosa Monica SantiagoPayao Spencer Luiz MarquesRasmussen Lucas Trevizani - To evaluate the impact of bimekizumab, a dual IL-17A and IL-17F inhibitor, on sacroiliac joint (SIJ) and spine inflammation/structural damage in axSpA using MRIs/radiographs from the phase 3 studies BE MOBILE 1 (nr-axSpA) and 2 (r-axSpA) and their open-label extension (OLE). - Source: PubMed
Publication date: 2026/09/14
Maksymowych Walter PRamiro SofiaPoddubnyy DenisBaraliakos XenofonLambert Robert G WMassow UteVaux TomPrajapati ChetanMarten Alexanderde Peyrecave NatashaØstergaard Mikkel - Primary mediastinal large B-cell lymphoma (PMBCL) predominantly affects female adolescents and young adults. It displays an immune-privileged phenotype and demonstrates the involvement of key cytokine signaling pathways, including increased expression of Thymus and activation-regulated chemokine (TARC/CCL17). Currently, there is a lack of established markers for stratification. We studied plasma concentrations of 24 cytokines at diagnosis in a large population-based pediatric cohort of 62 patients with PMBCL. Compared to a group of age-matched patients with other types of lymphoma in long-term remission and healthy individuals (n=26), we detected elevated concentrations of CCL4, CCL17, interleukin (IL)-6, CXCL8, CXCL9, CXCL10, and CXCL11. The median CCL17 level was 1695 pg/ml (IQR, 642-3142) in patients with PMBCL compared to 81 pg/ml (IQR, 41-190) in controls (p < 0.0001). Concentrations of CCL17, CXCL9, and CXCL10 significantly correlated with mediastinal tumor volume (MTV) and lactate dehydrogenase activity (LDH) but were not associated with event-free survival (EFS). Concentrations of IL-17F and IL-22 were inversely correlated with LDH and MTV. Elevated IL-6, IL-10, IL-17A, and IL-22 were significantly correlated with inferior EFS in a subgroup of 50 patients uniformly treated with dose-adjusted EPOCH with rituximab. Although based on a limited number of events, IL-6 showed the strongest association with outcome (hazard ratio of 6.8 (95%-CI, 1.5-30.9). In summary, pretreatment cytokine levels in patients with PMBCL reveal distinct patterns associated with tumor burden (CCL17, CXCL9, CXCL10) and outcome (IL-6, IL-10, IL-17A, IL-22). - Source: PubMed
Publication date: 2026/09/10
Nipper MalteDamm-Welk ChristineShepheard WillOschlies IlskeKlapper WolframBurkhardt BirgitWoessmann WilhelmKnörr Fabian - Hidradenitis suppurativa (HS) is an extremely painful skin condition with both nociceptive and neuropathic components. Biologics may offer superior neuropathic pain relief and impede worsening of this disease compared to other treatments. - Source: PubMed
Publication date: 2026/08/31
Feeney Josephine MHenderson Nikayla APatel Tanisha MArdoin Anna KAnwar Ahmed IAbd-Elsayed AlaaKaye Alan D - IL-17-producing Type 17 T (T17) cells are central drivers of inflammation in both psoriasis and hidradenitis suppurativa (HS), as evidenced by the clinical efficacy of IL-17-targeting therapies. However, therapeutic responses differ substantially between diseases, raising the possibility that the composition and regulation of T17 states are disease context dependent. - Source: PubMed
Publication date: 2026/08/14
Park NayoungLee JongeunKim DayeonRambhia DarshnaKim JaebumZhou WeiCao JunyueKrueger James GKo YounheeKim Jaehwan