Ask about this productRelated genes to: IL16 protein
- Gene:
- IL16 NIH gene
- Name:
- interleukin 16
- Previous symbol:
- -
- Synonyms:
- LCF, IL-16, prIL-16, HsT19289, FLJ42735, FLJ16806
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: IL16 protein
Related articles to: IL16 protein
- Early detection of gastric cancer (GC) remains challenging, and conventional serum tumor markers show limited sensitivity for precancerous gastric lesions. Inflammatory cytokines change during tumorigenesis and may provide complementary information for noninvasive screening. We evaluated whether serum cytokine profiling combined with routine tumor markers could improve discrimination across the spectrum from healthy mucosa to precancerous lesions and early GC. - Source: PubMed
Publication date: 2026/04/28
Zhang QiuyanZhai JingChen PuHan TiantianDeng XuetingMiao LinZhang Xiuhua - Monotherapies for lupus nephritis (LN) often fail to fully control the disease's hallmark, renal inflammation and immune complex deposition. This study investigates a novel combination therapeutic strategy using urolithin A (UA), a multifaceted anti-inflammatory and antioxidant agent, with cyclosporine A (CsA), an established immunosuppressant. The combination therapy's superior efficacy is evidenced by a robust reduction in immunoglobulin G (IgG) anti-dsDNA levels, with markedly improved renal function. The treatment also effectively mitigated immune complex deposition and multiple inflammatory chemokines, including I309, IL-16, and MIP-3. This alleviated kidney damage and suppressed lymphocyte infiltration. We found that CsA alone was ineffective across the analyzed markers, while UA alone produced only a modest effect, highlighting the complementary action of their combination. These findings underscore the potent anti-inflammatory and antioxidant properties of UA and suggest that combining it with CsA offers a more robust strategy for controlling inflammation and preserving renal integrity in LN. Given the FDA-approved status of CsA and UA's "generally recognized as safe" (GRAS) classification, this combination therapy presents a promising and practical clinical pathway for the treatment of lupus nephritis. - Source: PubMed
Ganugula RBabalola K TArora MMaruvada VPavuluri AKarthikeyan S KChandrashekar D SVarambally SAgarwal S KMohan CRavi Kumar M N V - Early diagnosis of Alzheimer's disease (AD) remains a formidable challenge. Although retinal markers are extensively studied, the cornea-the eye's primary transparent window-presents a potential but poorly understood platform for biomarker discovery. This study systematically characterized AD-associated corneal pathological evolution using the 5 × FAD mouse model. - Source: PubMed
Zhang DiHuang DuntaoHe JunjuShen YongDai LinbinShi Lei - Oral inflammatory diseases affect nearly half of all humans, yet mechanisms underlying rapidly-destructive inflammation remain poorly understood. We compared peri-implantitis with moderate- and high-grade periodontitis using integrated microbial and single-cell sequencing (>967,169-cells; single-cell RNA-seq, spatial proteotranscriptomics). Laser capture microdissection with compartmental microbiome analysis revealed reduced bacterial load and diversity in peri-implantitis. Expansion of the Human Periodontal Atlas with peri-implantitis single-cell RNA-seq data (36-samples; 121,395 cells) identified CD34 vascular endothelial cell (VEC) rarefaction and oxidative stress, hypoxia, and NAD⁺ metabolism-associated transcriptional programs enriched in a TNFRSF6B⁺/ICAM1⁺ post-capillary venule (PC-VEC) subpopulation. NAD⁺-consuming ectoenzyme CD38 was selectively enriched and orthogonally confirmed by spatial transcriptomics (6-samples; 283,377-cells) and proteomics (23-samples; 562,397-cells). Spatial neighborhood analyses demonstrated CD38⁺-high PC-VEC expansion, closer proximity, and higher IL16-CD4 T cell signaling in peri-implantitis. Matched high-grade periodontitis biopsies confirmed spatially restricted CD38⁺-VECs despite similar microbial burden, identifying endothelial vasculopathy underlying rapidly advancing oral inflammation and a potential therapeutic axis. - Source: PubMed
Publication date: 2026/05/08
Easter Quinn THuynh Khoa L AStolf Camila SchmidtXie JialiuMatuck Bruno FHasuike AkiraAlvarado-Martinez ZabdielKim William SChen ZhaoxuRibeiro Apoena AguiarPareek NiveditaAzcarate-Peril Andrea MWu DiCasarin RenatoKo Kang ILiu JinzeByrd Kevin M - Elevated remnant lipoproteins are a causal risk factor for atherosclerotic cardiovascular disease. We tested the hypothesis that low-grade inflammation can explain part of the increased risk of peripheral artery disease (PAD) and myocardial infarction conferred by elevated remnant lipoproteins; we also explored the causal effect of genetically elevated remnant cholesterol on inflammatory cytokine levels. - Source: PubMed
Publication date: 2026/05/01
Wadström Benjamin NWulff Anders BPedersen Kasper MNordestgaard Børge G