Ask about this productRelated genes to: CYR61 protein
- Gene:
- CCN1 NIH gene
- Name:
- cellular communication network factor 1
- Previous symbol:
- IGFBP10, CYR61
- Synonyms:
- GIG1
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-02
- Date modifiied:
- 2018-10-11
Related products to: CYR61 protein
Related articles to: CYR61 protein
- Hypoxic kidney injury remains difficult to treat due to the lack of therapies that effectively prevent podocyte injury and disease progression. Bioassay-guided investigation of Tabernaemontana pandacaqui yielded ten monoterpenoid indole alkaloids (MIAs), including eight new compounds with five unprecedented carbon skeletons. Notably, compound 6 is the first MIA monomer with a 6/5/6/5/6 pentacyclic diazaspiro[acenaphthylene-3,2'-indoline]-dione core containing three nitrogen atoms. Cytoprotective screening identified 2 and 6 with nanomolar potency (EC50 ≈ 22 nM). In a chronic hypoxic kidney injury mouse model, both compounds alleviated renal injury by restoring podocyte integrity and normalizing HIF-1α, p62, and LC3-II. Integrated activity-based protein profiling, chemical proteomics, RNA sequencing, molecular docking, and functional validation identified cellular communication network factor 1 (CCN1) as the molecular target of 2. Together, these findings expand the chemical space of MIAs, establish CCN1 as a therapeutic target for hypoxic kidney injury, and identify MIAs as a promising class of renoprotective leads. - Source: PubMed
Publication date: 2026/08/18
Qiao XueChen Shun-QingSarotti Ariel MZhang JixianZhong Yu-TingChen Wei-ChenWang XiaofenWang WumeiHuang JianyingWu Xiao-YanWang Hui-MingCao ShugengLi ZhengqiuWu QihaoXiao YulingHong XuechuanCai You-Sheng - Sarcopenia is a prevalent complication of chronic kidney disease (CKD), yet reliable biomarkers remain limited. CCN1, a matricellular protein involved in cellular senescence, has been implicated in muscle wasting, but its role in CKD-associated muscle strength decline is incompletely understood. - Source: PubMed
Publication date: 2026/08/21
Zuo YidanChen RuyiXu DiyanZhang WenliLuo ShengnanHu FeifeiSu Zhen - During brain development, neural stem progenitor cells (NSPCs) and microglia interact within precise spatial niches; however, decoding mechanism is full of challenges using traditional analytical techniques. Here, we investigated the role of CCN1, a secreted protein enriched in NSPCs, using CNS-specific knockout mice. Through single cell RNA-seq analysis, we found that microglia were significantly reduced in the ventricular zone (VZ) at E17.5 and P2, with elevated expression of autophagy- and activation-related genes in -CKO mice. Spatial transcriptomics at P2 further showed that deletion region-specific redistributes microglia and leads to increased microglial aggregation and activation in the rostral lateral septum (LSR), alongside reductions in the VZ. Mechanistically, deletion in NSCs led to region-specific dysregulation of the key signaling ligands, and . We found the elevated expression of and specifically within the LSR region, which corresponded to the up-regulation of their respective receptors (, ) and downstream targets (, ) in LSR microglia, affecting microglial status. Our study reveals a region-specific NSC-microglia interaction regulated by , offering a new paradigm for understanding multicellular dynamics in brain development. - Source: PubMed
Publication date: 2025/12/09
Bai ZhileChang ZhanheWang ShuguangZheng JiangliWu HuanLiu HanyuZhang YalinXie JiayangBai QingranYin JiqingWu YouShen QinGao ShaorongGao Yawei - Endometriosis is a chronic, inflammatory, estrogen-dependent disease that affects approximately 6-10% of women of reproductive age. The present study aimed to investigate the expression of 48 immune-related genes in different types of biological samples from patients with histologically confirmed endometriosis compared to a control group. We analyzed (1) patients' endometrial tissue, ectopic lesions, and menstrual and venous blood, as well as (2) the control group's endometrial tissue and menstrual and venous blood. After RNA isolation, expression analysis of 48 immune-related genes was performed using NanoString nCounter Elements XT technology. All samples were normalized using nSolver Analysis Software, including control normalization and the use of a reference gene, as well as additional approaches for the detection of reliable differential expression. Expressions of the analyzed genes were similar in venous blood between patients and the controls; no significant dysregulation was found in menstrual blood. Most of the analyzed genes were upregulated in patients' endometria. Three genes attracted our attention due to their overexpression in ectopic lesions. We were able to demonstrate the differential expression of three genes in ectopic lesions, suggesting their association with the development of endometriosis-, , and . The evidently higher expression of in the ectopic lesions nominates this molecule as a potential therapeutic target in endometriosis as well. - Source: PubMed
Publication date: 2026/08/01
Mihaylova ElianaNikolova DragomiraLechova-Dimitrova RalitsaVazharova RadoslavaValerieva ElitzaMagunska NadiaAndreeva PetiaMilanova MihaelaDimova Ivanka - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent but heterogeneous condition. How its genetic diversity shapes systemic disease risk remains unclear. We aimed to identify genetically defined MASLD subtypes, assess their effects on extrahepatic diseases, and uncover potential protein-mediated mechanisms. - Source: PubMed
Publication date: 2026/08/11
Weng YuxuanDu MingyiWu TianhaoLu LinyaoJiang YanfengSuo ChenJin LiZhang TiejunChen XingdongLiu Zhenqiu