Ask about this productRelated genes to: GDF11 protein
- Gene:
- GDF11 NIH gene
- Name:
- growth differentiation factor 11
- Previous symbol:
- -
- Synonyms:
- BMP-11
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-02
- Date modifiied:
- 2016-10-24
Related products to: GDF11 protein
Related articles to: GDF11 protein
- Aim: To explore link between circulating Growth Differentiation Factor 11 (GDF11) levels and atherogenic lipid parameters in individuals with diabetic dyslipidemia, and to evaluate whether GDF11 may serve as a potential biomarker to minimize atherosclerosis in this population. - Source: PubMed
Ghafil Nagham YahyaAli Sura Hadi Ibraheim Abd - Myostatin (MSTN) is a TGFβ family ligand that restricts muscle growth. Genetic loss-of-function in MSTN increases muscle mass, reduces fat accumulation, and improves metabolic health in mice and humans, with no known adverse phenotypes. Thus, depleting MSTN has therapeutic potential for obesity, sarcopenia, and other muscle wasting conditions. Recently developed monoclonal antibodies (mAbs) targeting MSTN or its receptors are expensive, require frequent injections/infusions, and risk a loss of efficacy from the development of anti-drug antibodies. Here, we report a comparatively inexpensive and durable alternative to mAbs, a virus-like particle (VLP)-based active immunotherapy, termed "MS2.87-97", that elicits an antibody response against a discrete and unique epitope in mature MSTN protein, with no cross-reactivity to GDF11. Compared to controls, MS2.87-97-treated mice had less age-associated weight gain and exhibited significantly reduced body fat by DEXA scan. MS2.87-97-treated mice also had significantly improved bodyweight-adjusted grip strength, and upon dissection, they were found to have increased muscle mass. No major safety concerns were identified. Echocardiography revealed no evidence of functional impairment of the heart, and histological analysis showed no change in myocardial collagen deposition (fibrosis). These initial findings support the continued preclinical development of MS2.87-97 as an immunotherapeutic for treating obesity, sarcopenia, and muscle wasting. - Source: PubMed
Publication date: 2026/04/08
Jacquez QuiteriaPeabody JulianneAcosta Eduardo HernandezChackerian BryceEndicott S Joseph - Alpha-terpineol (α-terpineol), a ubiquitous monoterpenoid alcohol found in numerous essential oils, is widely employed in cosmetics, perfumes, and aromatic therapies. Despite its extensive application, concerns regarding its potential reproductive and developmental toxicity remain inadequately characterized, particularly concerning specific teratogenic effects and underlying molecular mechanisms. This study presents novel findings, demonstrating that α-terpineol exposure during the critical organogenesis period significantly induces developmental toxicity in Wistar rat fetuses. α-terpineol was administered at the doses of 0, 75, 150, and 300 mg/kg with a dose volume of 5 mL/kg. We report dose-dependent embryotoxic and teratogenic effects, including reduced fetal weight and a spectrum of severe skeletal malformations such as anophthalmia, club foot, micrognathia, phocomelia, and irregularities in the vertebral column, ribs, and limb bones. Crucially, our comprehensive gene expression analysis revealed statistically significant alterations in the expression patterns of HOXD13 and GDF11, two pivotal genes essential for skeletal patterning and limb development. The observed downregulation of these genes suggests a potential molecular association into α-terpineol-induced teratogenesis. These findings underscore the significant developmental risks associated with α-terpineol exposure during pregnancy and provides insights into potential molecular changes underlying its teratogenic potential, warranting further investigation into human health implications and the establishment of safe exposure limits for this widely used compound. - Source: PubMed
Publication date: 2026/04/01
Hegde Sneha SumaMalashetty Vijaykumar B - Type 2 diabetes mellitus (T2DM) is the most common type of diabetes, which can cause various complications that threaten health. Long non-coding RNA (lncRNA) is associated with the occurrence and development of diabetes and its complications. - Source: PubMed
Publication date: 2026/04/03
Zeng YanSun LiyuLi JunliHuang ZhongyunYin Pengying - Human corneal endothelial cells rarely proliferate after embryonic development and exhibit limited regenerative capacity following injury. Previous studies reveal that the expression level of growth differentiation factor 11 (GDF11) is higher in fetal corneal endothelium compared with that in adults. However, the role of GDF11 in corneal endothelium has not yet been investigated. This study explores GDF11's role in corneal endothelial injury repair. In a mouse corneal cryoinjury model, GDF11 expression increases following injury. In vivo, adeno-associated virus-mediated regulation of GDF11 accelerates injury repair by promoting proliferation (an increase in Ki-67-positive cells), thereby restoring corneal transparency and thickness. In vitro experiments, knocking down or overexpressing GDF11 in cells, reveal that it promotes cell proliferation by regulating the cell cycle, while enhancing cell migration and inhibiting apoptosis. After GDF11 overexpression, mRNA sequencing of the cryoinjured mouse corneal endothelium suggests that GDF11 is associated with cell proliferation and the Wnt signaling pathway. Through in vitro and in vivo experiments, it was discovered that GDF11 regulates the SRY-box transcription factor 9 (SOX9)-β-catenin axis to promote cell proliferation, thereby providing a novel therapeutic target for corneal endothelial diseases. - Source: PubMed
Publication date: 2026/03/26
Li ZhaoLi XiaoqiLi ZongyuanChen MingxiongXie LuoyingWang AnYu HanruiBai GeWang QunHuang YifeiWang Liqiang