Ask about this productRelated genes to: CYP1A1 antibody
- Gene:
- CYP1A1 NIH gene
- Name:
- cytochrome P450 family 1 subfamily A member 1
- Previous symbol:
- CYP1
- Synonyms:
- P450DX, P1-450, P450-C, CP11
- Chromosome:
- 15q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CYP1A1 antibody
Related articles to: CYP1A1 antibody
- Cytochrome P4501A (CYP1A) is a widely used biomarker of environmental stress in fish, primarily associated with xenobiotic metabolism but also responsive to broader changes in water quality. This study provides a region-specific, field-based assessment of hepatic CYP1A responses in Cyprinus carpio in relation to nutrient enrichment across freshwater lakes of the North-Western Himalayas. Fish and water samples were collected monthly over two consecutive years from four lakes representing contrasting trophic conditions Viz Dal, Wular, Manasbal, and Nilnag along with laboratory-maintained control fish. Hepatic CYP1A concentrations were quantified, and concurrent measurements of total phosphorus, nitrate-nitrogen, ammonical nitrogen, dissolved oxygen, temperature, and pH were conducted.CYP1A levels showed pronounced spatial and seasonal variability, with significantly higher concentrations in fish from nutrient-enriched lakes, particularly Dal and Wular, compared to less impacted lakes and laboratory controls. These lakes were characterised by elevated nutrient concentrations and comparatively lower dissolved oxygen levels, reflecting eutrophic conditions. To appropriately address repeated monthly sampling and non-independence of observations, linear mixed-effects models were applied, incorporating lake and season as fixed effects and sampling event as a random effect. Model outputs indicated that total phosphorus and nitrate-nitrogen were significant predictors of CYP1A variation after accounting for seasonal and site-specific effects, whereas ammonical nitrogen showed no independent influence. The results suggest that nutrient enrichment indirectly modulates CYP1A expression through altered environmental conditions such as oxygen availability and metabolic stress rather than direct contaminant exposure alone. Overall, this study demonstrates the utility of CYP1A as an integrative biomarker of ecological stress under eutrophic conditions and highlights the importance of mixed-effects modelling in long-term freshwater biomonitoring. - Source: PubMed
Publication date: 2026/06/16
Andleeb SaimaShah AzraQazi DurdanaBazaz Asim IqbalBhat Irfan AhmadRather Mohd AshrafAsimi OyasShah Rashid AhmadKhan Irfan Ahmad - The aryl hydrocarbon receptor (AhR) is known to respond to various chemicals as a sensor for environmental chemicals that induce drug-metabolizing enzymes; however, reports on its activation by pesticides and herbicides remain limited. We evaluated compounds from commonly used pesticides and herbicides that modulate AhR using a yeast reporter gene assay. Notably, bromacil (Brm), which is a uracil herbicide, exhibited ligand-like activity with mouse AhR in a yeast-based assay used for first screening., functioning as an antagonist and inducing AhR nuclear translocation in human cells, while exhibiting no cytotoxicity or mutagenicity. Although AhR modulators may be nontoxic, they could alter the mutagenicity of procarcinogens, which are metabolically activated by inducing the expressions of drug-metabolizing enzymes. Co-exposure to Brm and benzo[a]pyrene (BaP) reduced BaP-induced cytotoxicity and mutagenicity. Moreover, Brm induced Nrf2 activation and upregulated its target gene mRNA levels in an AhR-dependent manner, which may contribute to the observed attenuation of BaP-induced cytotoxicity and mutagenicity. These findings indicated that Brm is a novel AhR antagonist that modifies AhR-mediated chemical toxicity through AhR inhibition and Nrf2 activation. - Source: PubMed
Publication date: 2026/06/12
Koike MebaeTakemoto ShunKomatsu ShowaKarube RikakoKanamaru SakiShiozawa MinamiShiizaki Kazuhiro - Dendritic cells (DCs) activate CD4 T cells by presenting antigens via MHCII. MHCII surface levels are regulated by diverse mechanisms, including ubiquitination. The aryl hydrocarbon receptor (AhR) further modulates MHCII expression and DC function. Whether monocyte-derived dendritic cells (mo-DCs) regulate antigen presentation by sensing exogenous antigens through the AhR remains unclear. - Source: PubMed
Publication date: 2026/06/12
Xie HuanchengWu HanxiWang JingLi LinmeiHe YingWang YingHuang YuyiYan JieSun WeiminTao Ailin - Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with adverse cardiometabolic outcomes. But the molecular mechanism is still unexplored. The purpose of our study is to investigate the relationship between exposure to PAHs and cardiometabolic dysfunction, and to explore the mechanism and molecular pathways. - Source: PubMed
Publication date: 2026/06/09
Du ZiyePan YuxinZhan HuiyiWang ZhentingZhao Mingyi - Postmenopausal osteoporosis (PMOP) involves bone loss and fracture risk, driven by estrogen deficiency, oxidative stress, immune dysregulation, and endocrine alterations. Bushen Huoxue Decoction is used for osteoporosis, but its mechanisms in PMOP are unclear. - Source: PubMed
Publication date: 2026/06/11
Yin LiChen XinXu Jianli