Ask about this productRelated genes to: CYP1A1 antibody
- Gene:
- CYP1A1 NIH gene
- Name:
- cytochrome P450 family 1 subfamily A member 1
- Previous symbol:
- CYP1
- Synonyms:
- P450DX, P1-450, P450-C, CP11
- Chromosome:
- 15q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CYP1A1 antibody
Related articles to: CYP1A1 antibody
- Oral submucous fibrosis (OSF) is a chronic and insidious oral disease characterized by hyalinization of the subepithelial connective tissue and progressive fibrosis of the oral submucosa. It is a precancerous condition of oral squamous cell carcinoma. Studies have demonstrated that single nucleotide polymorphisms (SNPs) are closely associated with susceptibility to OSF. This study aims to comprehensively evaluate the association between SNPs and OSF risk and to rank the strength of the association between different genetic models and OSF susceptibility. - Source: PubMed
Huang ChunxiaLiu JuanZeng BinZhang LeleZhou ZhihangHuang XiaoshanHe BinshengBao Meihua - The aryl hydrocarbon receptor (AHR) is a central mediator of cellular responses to environmental exposures, including cigarette smoke. Appropriate selection of in vitro hepatic models is critical for investigating AHR-dependent induction of xenobiotic-metabolizing enzymes. Therefore, The aim of this study was to compare AHR-mediated induction of CYP1A1 and CYP1A2 across five human hepatic in vitro models to identify the most suitable model. Primary human hepatocytes (PHH), HepaRG, HepG2, HuH-7, and upcyte® hepatocytes were exposed to cigarette smoke extract and prototypical CYP inducers, responses were assessed at mRNA and enzyme activity levels. PHH confirmed their role as gold standard model, while HepaRG cells emerged as practical and ethical alternative for mechanistic studies. HepG2 and HuH-7 showed limited responsiveness. Upcyte® hepatocytes displayed strongly elevated fold changes, compared to other models. Overall, pronounced model-specific differences in AHR responsiveness emphasize the importance of informed in vitro model selection for exposure-relevant studies. By directly contrasting transcript and functional activity endpoints across five models, this work clarifies strengths and limitations that are often not apparent in single-model studies. Therefore, this work provides practical guidance for informed model selection in studies of the AHR signaling pathway. - Source: PubMed
Publication date: 2026/09/04
Lenich Ann-KathrinReindl Lisa-MarieRuez Stephanie - Benzo(a)pyrene (BaP), a widespread environmental and food pollutant, induces cellular toxicity through CYP1A1-mediated metabolic activation. This study demonstrated that neohesperidin (NH) and neohesperidin dihydrochalcone (NHDC) effectively inhibited CYP1A1 activity. The recombinant CYP1A1 protein expressed in E. coli confirmed these inhibitory effects in vitro. Using a HepG2 cell model, both NH and NHDC significantly alleviated BaP-induced cytotoxicity and oxidative stress, as evidenced by enhanced cell viability and upregulated HO-1, NQO-1, and Nrf-2 expression. Comet assay results further showed that NH and NHDC reduced BaP-induced DNA damage. Molecular docking revealed stable binding interactions between NH, NHDC, and CYP1A1 active sites. Collectively, NH and NHDC attenuated BaP-induced hepatocellular injury in association with CYP1A1 inhibition and enhancement antioxidant defense. These findings highlight their potential as natural chemoprotective agents and demonstrate the value of molecular docking for identifying bioactive compounds with specific functional properties. - Source: PubMed
Publication date: 2026/09/03
Hao RiliGe JunlinDu ShuchengBai JieYang ZhongyuYe YutingGuan HuiLi Dapeng - Lung ischemia-reperfusion injury (LIRI) is a serious complication of lung transplantation that causes respiratory distress and is associated with high mortality. Ferroptosis, a novel form of programmed cell death, contributes to the pathogenesis of LIRI. The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcription factor that regulates a variety of physiological functions. However, the role and mechanism of AhR in ferroptosis during LIRI after lung transplantation remain to be further investigated. - Source: PubMed
Publication date: 2026/08/27
Deng PengXu GuanghuaWan LiXu JianweiYao ZuhuanSun Quanchao - Increasing studies investigate the association of polymorphisms in carcinogen-metabolizing enzymes with oral potentially malignant disorder (OPMD) progression to oral squamous cell carcinoma (OSCC) risk. However, these results remain inconsistent and conflicting. This pooled analysis aimed to systematically evaluate the 5 enzymes (CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1) polymorphisms in OPMD versus OSCC. - Source: PubMed
Publication date: 2026/04/01
Xu ZiyuanZhu YuhanShi LinjunLiu Wei