Ask about this productRelated genes to: CYP1A1 antibody
- Gene:
- CYP1A1 NIH gene
- Name:
- cytochrome P450 family 1 subfamily A member 1
- Previous symbol:
- CYP1
- Synonyms:
- P450DX, P1-450, P450-C, CP11
- Chromosome:
- 15q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CYP1A1 antibody
Related articles to: CYP1A1 antibody
- Triazole fungicides are ubiquitous in agricultural practices, yet the multifaceted mechanisms underlying their hepatotoxicity remain inadequately defined. In this study, we employed an integrated multi-omics framework, incorporating network toxicology, transcriptomics, untargeted metabolomics, and molecular docking, to investigate the effects of flusilazole (10 μM) on AML12 mouse hepatocytes. Molecular docking established a robust mechanistic nexus between flusilazole and Cytochrome P450 (CYP) enzymes, revealing high binding affinities for CYP51, CYP1A1, and CYP2D22. These interactions correlated with a profound systemic disruption of lipid homeostasis, specifically the blockade of steroid hormone biosynthesis and the perturbation of sphingolipid metabolism. Integrated O2PLS and pathway analysis identified concordant transcriptomic and metabolomic alterations in the tryptophan-NAD and pentose phosphate pathways. These findings suggest a hypothesized metabolic cascade wherein flusilazole-induced enzymatic inhibition shunts tryptophan flux away from de novo NAD biosynthesis, potentially triggering a bioenergetic crisis. This is further evidenced by a compensatory shift toward the pentose phosphate pathway and the activation of IL-17/TNF stress-response signaling. Comparative analysis further distinguishes flusilazole through its specific suppression of circadian rhythm and DNA replication signatures. Collectively, our results provide a holistic and data-anchored perspective on flusilazole-induced hepatotoxicity, highlighting the interplay between enzymatic blockade, metabolic reprogramming, and chronobiological desynchronization as critical drivers of triazole-mediated hepatic injury. SYNOPSIS: Flusilazole, a widely used triazole fungicide, disrupts endocrine balance and amplifies mixture toxicity risks through conserved biological targets, threatening ecosystem and human health. - Source: PubMed
Publication date: 2026/03/12
Zhang ShenghanYu XiLiu YinuoGuo YunliangLiu YingjuanLi Xu - Doxorubicin alone or in combination is widely used as first- or second-line chemotherapy in multiple solid tumors. Yet poor overall/progression-free survival and high mortality reflect the inherent Dox-resistance. Such resistance significantly limits the response to anthracycline-containing regimens. Frequent occurrence of TP53 mutations across cancers suggests that mutant-p53 may drive selective chemoresistance towards first- and second-line chemotherapeutics but the underlying mechanism remains inadequately explored. - Source: PubMed
Publication date: 2026/04/16
Mehrotra MeghaShenoy Priti SSakpal AsmitaChakraborty SouravRay Pritha - The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug-metabolizing enzymes (DMEs). - Source: PubMed
Yu HanaLee Song HeeKim Ji HyeonKim Seung JinKang Hee Eun - Elevated water hardness (HW) level could negatively impact the health of various kinds of fish, especially Nile tilapia. The current work aimed to explore the cytoprotective role of rutin (RUT), a natural antioxidant, against HW-induced cell injury in Nile tilapia, and to find the possible mechanistic pathways underlying this protection. Sixty monosex fish were allocated into four different experimental groups (n = 15): control, RUT (1 g/kg), HW-exposed group (300 ppm) and HW + RUT group. The daily exposure of fish to elevated HW for 90 days significantly altered the haematological profile, increased malondialdehyde (MDA) and nitric oxide (NO) levels and reduced the antioxidant enzyme activity. Additionally, it elevated the serum levels of both liver and kidney function biomarkers, alongside pronounced histopathological alterations in gills, the liver and kidneys. Mechanistically, the HW markedly increased the expression of either gene or protein levels of iNOS, casp-3, CYP1A1, MT-1 and Hsp70 in both the liver and kidneys, alongside strong proliferating cell nuclear antigen (PCNA) immunoexpression in the gills. In contrast, dietary RUT effectively ameliorated the toxicological alterations induced by elevated HW, contributing to the enhancement of immune and antioxidant defence mechanisms, which therefore reduced the aforementioned cell signalling pathways. In conclusion, the potent antioxidant, anti-apoptotic and immunostimulant properties of RUT can contribute to reducing HW-induced toxicity in Nile tilapia. - Source: PubMed
Publication date: 2026/04/21
Mohamed Wafaa AHassanen Eman IKhalefa Hanan SHassan Neven HIbrahim Marwa AMahmoud Mahmoud A - Chronic kidney disease (CKD) and chronic obstructive pulmonary disease (COPD) frequently present as comorbid conditions, while the underlying mechanisms remain largely unknown. Therefore, we aimed to explore the genetic correlations, shared genetic variants, and potential causal relationships between five kidney function traits (serum creatinine-based estimated glomerular filtration rate (eGFRcrea), cystatin C-based estimated glomerular filtration rate (eGFRcys), blood urea nitrogen (BUN), urinary albumin-to-creatinine ratio (UACR), urate) and four lung function traits (forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio (RATIO), and peak expiratory flow (PEF)), using data from UK Biobank and CKDGen Consortium with a total of about 1 004 040 participants. Our genome-wide cross-trait study found a strong genetic correlation between eGFRcys, urate, and FVC, and causal analysis using summary effect estimates further confirmed a negative causal effect of FVC on urate while identifying a positive causal effect of eGFRcrea on the RATIO. Cross-trait analysis uncovered 6 overlapped genes significantly shared across 20 trait pairs. Another 7 key genes were further found via transcriptome-wide association, colocalization, and fine-mapping analyses. These 13 key genes converged on four major biological functions, including immune response, endogenous compounds, developmental regulation, and olfactory receptors. Notably, six genes: RF00017, ZNF391, CYP1A1, CYP1A2, OR2J2, and OR14J1, showed novel links to both kidney and lung function traits. These findings uncover the genetic basis of kidney-lung interorgan communication and identify potential therapeutic strategies for reducing multi-system comorbidity. - Source: PubMed
Su ShiqiXiang NanyanYao PeijiYang YongSu ShuFu TingtingWang LeLiao ShuyuanLi WeiminLin YifeiHuang Jin