Ask about this productRelated genes to: TRPA1 antibody
- Gene:
- TRPA1 NIH gene
- Name:
- transient receptor potential cation channel subfamily A member 1
- Previous symbol:
- ANKTM1
- Synonyms:
- -
- Chromosome:
- 8q21.11
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-15
- Date modifiied:
- 2016-10-05
Related products to: TRPA1 antibody
Related articles to: TRPA1 antibody
- Chronic cough is increasingly viewed as a heterogeneous clinical syndrome associated with cough hypersensitivity, not simply a symptom defined by duration. This review examines key mechanisms in chronic cough, the reasons why mechanistic insights have translated poorly into therapy, and future directions involving patient stratification and biomarkers. - Source: PubMed
Publication date: 2026/05/28
Yang XinyueDuan Xianglong - Allergic contact dermatitis (ACD) is a common inflammatory skin condition characterized by cutaneous inflammation and pruritus. Purinergic 2X receptor 3 (P2X3) and transient receptor potential ankyrin 1 (TRPA1) are implicated in acute and chronic pruritus, but their interactions remain unclear. Sesamin has anti-inflammatory, antioxidant, and antitumor properties; however, its effectiveness in alleviating ACD and the underlying mechanism remain unknown. In this study, male C57BL/6 mice (20-25 g body weight) were used. Results showed that squaric acid dibutylester (SADBE) increased scratching behavior and upregulated P2X3, TRPA1, IL-1β, and TNF-α expression in the right trigeminal ganglion (TG). Intraperitoneal administration of sesamin attenuated these effects, reducing pruritic behavior and inflammation-related gene expression. Compared to the control group, the ACD model group showed significantly increased co-expression of Mas-related G protein-coupled receptor member A3 (MrgprA3) and P2X3. Transfection experiments in HEK293 cells demonstrated that P2X3 regulated TRPA1 channel activation by modulating intracellular calcium levels. These findings suggest that sesamin alleviates pruritus in ACD mice, likely through downregulation of P2X3 and suppression of P2X3-mediated intracellular calcium elevation. Furthermore, sesamin inhibited TRPA1 expression and reduced calcium levels in cells co-transfected with the TRPA1 plasmid. Thus, sesamin may attenuate activation and expression of the inflammatory receptor TRPA1 by inhibiting P2X3, highlighting its potential as an antipruritic agent for SADBE-induced ACD. - Source: PubMed
Publication date: 2026/05/28
Ma XiaoqianZhang YuanyuanYang YuxinSun YusenLiang ShangdongLi Guilin - Renal ischemia and reperfusion (I/R) injury is a potentially serious issue encountered during various medical and surgical procedures. This condition is clinically significant because of its high incidence and mortality rate. In this study, we aimed to investigate the protective effect of dexmedetomidine (DEX) on oxidative stress-activated TRPM2 and TRPA1 channel expression in rats with a renal I/R model. - Source: PubMed
Uzunboy AbdulkadirKuloglu TuncayDemirel OguzhanTurk AhmetAltuntas GülsümBolat Esef - This study aimed to evaluate the effect of pulsed radiofrequency (PRF) treatment with various time courses on rheumatoid arthritis (RA)-caused joint pain and pathological damage in rats. - Source: PubMed
Publication date: 2026/05/22
Li XinWang MengWang YingDiZhao GangGao JuWang Cunjin - Carpesium abrotanoides L. (Asteraceae) is traditionally used to treat inflammatory conditions including bronchitis, sore throat, and tonsillitis. However, the evidence supporting its potential in chronic obstructive pulmonary disease (COPD) treatment remains limited. - Source: PubMed
Publication date: 2026/05/26
Han Yoo KyongKim So YeonYang Won-KyungJi Yeong EunKim Seung-HyungKim Dong-SeonSung Yoon-Young