Ask about this productRelated genes to: TRPV2 antibody
- Gene:
- TRPV2 NIH gene
- Name:
- transient receptor potential cation channel subfamily V member 2
- Previous symbol:
- -
- Synonyms:
- VRL, VRL-1, VRL1
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-29
- Date modifiied:
- 2016-01-28
Related products to: TRPV2 antibody
Related articles to: TRPV2 antibody
- Brown and Beige adipocytes play a pivotal role in energy dissipation and metabolic homeostasis, and emerge as an attractive target for obesity and metabolic disease. Transient receptor potential (TRP) channels function as key sensory-metabolic transducers that integrate thermal, chemical, and dietary stimuli to modulate thermogenesis, adipocyte differentiation, mitochondrial activity, and sympathetic outflow. Several members of TRP channel family, including, TRPV1, TRPV2, TRPV3, TRPV4, TRPM2, TRPM8, and TRPA1, influence adipose tissue plasticity however their role is variably understood. This review synthesizes current knowledge on TRP channels as nodal regulators of Ca-dependent signaling in brown and beige adipocytes, with a focus on AMPK/SIRT1 and PGC-1α pathways, mitochondrial remodeling, and neuro-adipose crosstalk. Dietary and natural TRP agonists such as capsaicin, menthol, cinnamaldehyde, and allyl isothiocyanate, consistently promote thermogenesis and metabolic benefits in preclinical models and emerging evidence suggests the potential for additive or cooperative metabolic effects when TRP agonists are combined with other therapeutic strategies, including incretin-based approaches; however, formal evidence of pharmacological synergy remains limited. Here, we critically review mechanistic insights linking TRP channel activation to thermogenic reprogramming, adipocyte differentiation, and CNS-adipose crosstalk. We further highlight the opportunities and challenges of leveraging TRP channels as polypharmacological targets in obesity therapeutics, with particular emphasis on natural agonists and combination therapies. This emerging field holds substantial promise, yet requires rigorous translational validation to establish safety, efficacy, and long-term metabolic benefits in humans. - Source: PubMed
Publication date: 2026/04/30
Mukheja YashdeepLal RoshanSoni NehaKaur JasleenKhare PragyanshuKondepudi Kanthi KiranChopra KanwaljitBishnoi Mahendra - Investigating strategies to enhance T cell effector function can improve the adoptive immune responses to tumors and complement existing tumor immunotherapies. Here, we present a novel artificially designed recombinant protein, PK5-Gal-3C, which is composed of the fifth kringle domain of plasminogen (PK5) and the C-terminal carbohydrate-recognition domain of galectin-3 (Gal-3C). This protein exhibited potent anti-tumor activity by significantly enhancing T cell effector function. Specifically, PK5-Gal-3C directly activated T cells by binding to glycosylated TRPV2 via Gal-3C, a thermosensitive calcium-permeable cation channel, thereby promoting the influx of calcium ions to enhance T cells cytotoxicity via the activation of c-Jun. Correspondingly, inhibition of TRPV2 or c-Jun impaired the cytotoxicity of T cell mediated by PK5-Gal-3C. Additionally, PK5-Gal-3C demonstrated significant anti-tumor activity by enhancing T cell tumor infiltration and cytotoxicity in a mouse model, as well as improving the anti-tumor efficacy of CAR-T cells in solid tumors. In summary, PK5-Gal-3C is a safe and potent anti-tumor agent with promising potential for T cell-mediated cancer immunotherapy. - Source: PubMed
Publication date: 2026/05/08
Zhang GuopengZhang WeiWei XiaohuanWang ZhenyuWang FeitongSun ShishuoXu HaihengLiu XiangyeZhang QingGao Xiaoge - Poultry birds are exposed to diverse environmental stressors, including high ambient temperatures and endotoxins, which negatively affect the birds' health and productivity. This study investigated the impacts of both stressors and the mediatory role of dietary L-citrulline (LCT) on the physiological responses of broiler chickens. - Source: PubMed
Publication date: 2026/04/21
Li LanUyanga Victoria AnthonyJiao HongchaoZhao JingpengWang XiaojuanLi HaifangTona KoukouLin Hai - Following their domestication, chickens were translocated around the world to novel environments. Through a combination of natural and artificial selection, chickens adapted to these local conditions, creating significant genetic diversity across populations worldwide. Studying this diversity in the context of local environmental conditions may offer insights into mechanisms of adaptation to environmental stressors. In this study, we analyzed genomic data from the Chicken Genomic Diversity Consortium, applying multiple statistical approaches, including fixation index (F), nucleotide diversity (π), Tajima’s D, and runs of homozygosity (ROH), to identify selective sweeps among indigenous chickens from Afghanistan, China, Indonesia, Iran and Pakistan, compared with White Leghorn chickens. We identified sweeps in 14 genes related to heat tolerance, associated with relevant gene ontology (GO) terms and located within ROH regions. These genes, such as , , , , , , , , , , , , , , and play crucial roles in calcium signaling pathways, thermal sensation, and the plasticity of neurodevelopmental processes. These findings illustrate the significant role of selection in shaping genomic differentiation across chicken populations and provide insights into the genetic basis of adaptation to environmental stressors. - Source: PubMed
Publication date: 2026/04/07
Hosseinzadeh SevdaRafat Seyed AbbasJavanmard ArashHasanpur KarimBardou PhilippeCharles MathieuKlopp ChristopheSmith Adrian LFiddaman Steven R - Skeletal muscle responds to stressors such as exercise and muscle injury by adaptive remodelling. The resilience of skeletal muscle involves not only mature muscle fibres but also the adjacent muscle satellite cells (MuSCs). We previously found that transient receptor potential vanilloid type 2 (TRPV2) is expressed in MuSCs and is essential for MuSC proliferation and activation in MuSC-specific conditional knockout mice. These mice show no mechanical-load-induced muscle hypertrophy and delayed injury-induced muscle regeneration. The effect of TRPV2 on Ca signalling during early myogenesis is unknown; however, here, we demonstrate that tranilast, an inhibitor of TRPV2, suppressed IPR-derived Ca oscillations in early myogenesis. The addition of adenovirus (Ad)-TRPV2 or Ad-Cre recombinase to floxed-TRPV2 cells modulated TRPV2 expression, and demonstrated the TRPV2 dependence of IPR and MEF2c expression, nuclear translocation of MEF2c, and Ca oscillations. These findings indicate that TRPV2 regulates intracellular Ca signalling during early myogenesis and highlight its potential as a target for the prevention and treatment of muscle disorders. - Source: PubMed
Publication date: 2026/03/25
Chen YanzhuKatanosaka KimiakiKatanosaka Yuki