Ask about this productRelated genes to: PRKCZ antibody
- Gene:
- PRKCZ NIH gene
- Name:
- protein kinase C zeta
- Previous symbol:
- -
- Synonyms:
- PKC2
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-10-05
Related products to: PRKCZ antibody
Related articles to: PRKCZ antibody
- Tetrabromobisphenol A (TBBPA), a widely used brominated flame retardant, bioaccumulates in the liver and disrupts glucolipid homeostasis, yet its diet-dependent metabolic effects remain unclear. This study investigated how differing dietary fat levels modulate TBBPA-induced hepatic disturbances. Adult zebrafish were exposed to environmentally relevant concentrations of TBBPA (10 and 100 nM) for 4 weeks under normal-fat (6% crude fat) or high-fat (24% crude fat) diets. Morphological and biochemical assessments, combined with integrated metabolomic and transcriptomic analyses, revealed distinct diet-specific mechanisms. Under normal-fat conditions, TBBPA activated the and axes, enhancing gluconeogenesis and lipogenesis and inducing selective hepatic insulin resistance manifested by hyperglycemia, hyperinsulinemia, and adiposity. Conversely, under high-fat conditions, TBBPA decreased IRS1 abundance and phosphorylation, suppressing insulin signaling and leading to complete hepatic insulin resistance with hyperglycemia, reduced lipid deposition, and body-weight loss. These findings demonstrate that the dietary fat content critically shapes TBBPA-induced metabolic toxicity and highlight the need to incorporate nutritional status into the health-risk assessment of brominated flame retardants. - Source: PubMed
Publication date: 2026/03/16
Ren XinxinGuo YongyongLi BingjieXu TaoWang BingfeiYang LihuaHan JianZhou YuxiZhou Bingsheng - Long-term memory formation transiently activates Ca-calmodulin kinase II and atypical protein kinase C isoform iota/lambda, whereas persistent activation of the other atypical PKC, protein kinase M zeta (PKMζ), together with its interacting partner, the scaffolding-protein KIBRA (Wwc1), are necessary for maintaining potentiated synapses and memory. Here, we use immediate-early gene (IEG) Arc activation during active place avoidance memory expression to tag memory-activated neurons with EYFP-ChR2. PKMζ immunohistochemistry identified persistently altered hippocampal somatodendritic domains. EYFP-PKMζ colocalization persistently increases in the hippocampal trisynaptic pathway (dentate gyrus [DG]→CA3→CA1) tracing a 1-month PKMζ engram. DG, CA3, and CA1 transcriptional profiling identifies that memory persistence correlates with upregulated IEGs Arc, Fos, and NPas4 in DG, but not with Prkcz, the PKMζ gene, or most genes known to be crucial for LTP and memory. This rules out strong memory-related transcriptional but not translational regulation or altered stability of such "shadow proteins" like PKMζ that, despite being crucial for memory maintenance, evade detection by unbiased transcriptome profiling. In contrast, our method Correlation Signal Co-cluster Reduction (C-SCoRe) incorporates weak linear and non-linear gene correlations and highlights network interaction changes predicting memory, and related IEG and Prkcz/Wwc1 expression. Manifold transcriptional relationships can reveal shadow molecular components of long-term memory. - Source: PubMed
Publication date: 2026/03/13
Han JiyeonGrau-Perales AlejandroHarris Rayna MLesburguères EdithKao Hsin-YiPal AsitAlarcon Juan MarcosSacktor Todd CMartiniani StefanoHofmann Hans AFenton André A - The clinical relevance of non-HLA antibodies remains uncertain due to the lack of standardized assays. This study aimed to assess comparative reference values for non-HLA antibody profiles in a cohort of kidney transplant candidates on the deceased donor waiting list (WL group) with 0% calculated panel reactive antibodies (cPRA) and in healthy male blood donors (BD group). - Source: PubMed
Publication date: 2026/02/13
Quintiliano AAgrawal AZuccarelli MWakefield L LSchinstock C AGandhi M JBentall A J - Alternative splicing (AS) serves as a fundamental mechanism governing proteomic diversity in brain cells throughout development and adulthood, profoundly influencing cell differentiation and synaptic plasticity. In this study we used a model system of rat primary neuron cultures to examine how global chromatin remodeling induced by the broad-spectrum HDAC inhibitor trichostatin A (TSA) influences local AS patterns in plasticity-related genes and explored their possible functional implications for synaptic functioning. Analysis of transcriptomic data uncovered a widespread dynamic AS-induced changes in plasticity-related genes through both transcription-coupled and post-transcriptional mechanisms. We found that prolonged TSA treatment preferentially alters the exon composition in genes involved in synapse organization and signal transduction. Using quantitative PCR, we validated these results for selected genes encoding involved in synaptic functioning cell adhesion molecules (, ), scaffold proteins (, ), glutamate receptors (), and signaling molecules (, ). To determine whether these molecular changes correlate with neural network activity, we performed calcium imaging in neuron cultures expressing the genetically encoded calcium sensor GCaMP6s. We found that molecular rearrangements accompanied the temporally delayed substantial network reorganization, which appeared at 19 h as an increased synchronization of neuronal activity, followed by elevated neuronal excitability at 48 h. These results establish a novel mechanistic link between epigenetic regulation, AS dynamics, and synaptic functioning, explaining how the HDAC inhibitors can enhance synaptic plasticity. Furthermore, our findings provide novel insights into molecular basis of neurological disorders associated with splicing dysregulation, offering new directions for therapeutic interventions. - Source: PubMed
Publication date: 2026/02/11
Beletskiy A PLeontovich Yu AAseyev N ABalaban P MBorodinova A A - Breast cancer (BC) is the most common malignancy afflicting women worldwide, yet the role of relaxin-related genes (RLN) in BC progression remains unclear. This study aims to elucidate the relationship between RLN and BC outcomes through immune microenvironment and metabolic pathway analysis. - Source: PubMed
Publication date: 2026/01/24
Du YiYuan QuanYu HaoYe RongjieLin HuanYu GeNiu MingQiu Huilei