Ask about this productRelated genes to: PDE3A antibody
- Gene:
- PDE3A NIH gene
- Name:
- phosphodiesterase 3A
- Previous symbol:
- -
- Synonyms:
- CGI-PDE
- Chromosome:
- 12p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-29
- Date modifiied:
- 2018-07-11
Related products to: PDE3A antibody
Related articles to: PDE3A antibody
- [This corrects the article DOI: 10.3389/fvets.2026.1821251.]. - Source: PubMed
Publication date: 2026/06/29
Widjiati WidjiatiLuqman Epy MuhammadDarsini NinikAulanni'am Aulanni'amHendrawan Viski FitriKurniawati Devia YoanitaJaafar Wan Nor Fitri Bin Wan - A major regulator of the intraoocyte levels of cAMP is the cGMP-inhibited PDE3A. This oocyte-specific PDE hydrolyses cAMP, counterbalancing its autonomous GPR3 production and gap junctional transfer from the follicle soma. The pituitary luteinizing hormone (LH) induces resumption of meiosis by reducing the somatic cGMP, which in concomitance with closure of gap junctions lowers its availability to the oocyte. Nevertheless, unlike cGMP, LH elevates the follicle cAMP. This apparent paradox questions whether and how the somatic cAMP elevation serves reinitiation of meiosis. To challenge this intriguing option, we used rat ovarian follicle clusters and cumulus-enclosed/cumulus-free, fully-grown oocytes. The oocytes were incubated with dbcAMP to elevate their cAMP. Follicles were incubated with LH to induce resumption of meiosis. Participation of NO-iNOS pathway was evaluated by either the NO-donor, SNAP or the iNOS inhibitor AG, and involvement of cGMP by a selective sGC inhibitor, ODQ. At the end of incubations, PDE3A activity as well as cAMP concentrations within oocytes were determined. We detected a LH-induced immediate elevation of intra-oocyte cAMP, followed by PKA-mediated activation of PDE3A. Both events were depended on open gap junctions. At this time window, the LH-induced decrease in granulosa-cells NO production followed by reduction in cGMP contributed to the relief of PDE3A inhibition. The later termination of cell-to-cell communication backed a sustained PDE3A activity by stopping the transfer of both, cAMP and cGMP. Our present study suggests that the transient increase in intraoocyte cAMP, which activates the oocyte PDE3A, may serve as a complementary mechanism, to increase the efficiency of LH-induced oocyte maturation. - Source: PubMed
Publication date: 2026/07/02
Gershon EranMaimon IrisElbaz MichalGaliani DaliaDekel Nava - Synovial sarcoma (SS) is molecularly defined by the pathognomonic fusion, a master epigenetic driver. While gene fusions are high-priority tissue-agnostic targets for TRK inhibitors like larotrectinib, their co-occurrence with established lineage-defining drivers in sarcomas is exceptionally rare and presents a therapeutic paradox. - Source: PubMed
Publication date: 2026/06/30
Ismayilov RashadOz BugeOguz ArzuAltundag Ozden - Can oocyte maturation be adapted to a phenotypic assay within a drug screening pipeline to identify compounds that block meiotic progression for female non-hormonal contraceptive drug discovery? - Source: PubMed
Publication date: 2026/05/29
Pea JeffreyZhu YiruLee Hoi ChangHaky Lauren RProudfoot JohnNelson RichardDuncan Francesca E - Although follicular development and oocyte competence depend on insulin-like growth factor-1 (IGF-1), its optimal dose and molecular mechanisms during goat maturation (IVM) remain unclear. - Source: PubMed
Publication date: 2026/05/29
Widjiati WidjiatiLuqman Epy MuhammadDarsini NinikAulanni'am Aulanni'amHendrawan Viski FitriKurniawati Devia YoanitaJaafar Wan Nor Fitri Bin Wan