Ask about this productRelated genes to: PDE7B antibody
- Gene:
- PDE7B NIH gene
- Name:
- phosphodiesterase 7B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-07
- Date modifiied:
- 2016-10-05
Related products to: PDE7B antibody
Related articles to: PDE7B antibody
- Intramuscular fat (IMF) content is an important factor for meat quality evaluation, which varies between species, and mainly involves the number and size of intramuscular adipocytes. However, the potential mechanism has not been well elucidated. In this study, the whole transcriptomic data of longissimus dorsi muscle from Laiwu pigs (LW, fatty type) and Duroc×Landrace×Yorkshire pigs (DLY, lean type) were collected and an in-depth analysis was conducted. Through differentially expressed analysis between species, 1899 mRNAs, 10 microRNAs (miRNAs), and 247 circular RNAs were identified. An integrated analysis of differentially expressed mRNAs and miRNAs generated two network modules that potentially regulate IMF formation in LW pigs, one consisted of 13 mRNAs (such as ESR1 and COQ3) and one miRNA gene (ssc-miR-874), and another included 31 mRNAs (such as SCML4 and PDE7B) and three miRNAs (ssc-miR-125a, ssc-miR-1343, and ssc-miR-204). In addition, a competitive endogenous RNA network including 13 circular RNAs, three miRNAs, and 31 genes was also delineated, which is probably involved in differential regulatory patterns of IMF deposition between LW and DLY pigs. The function of the SCML4 gene was verified with the 3T3-L1 cell line in vitro, and, when SCML4 was decreased, the expression of key proteins associated with fat formation (PPARγ and FABP4) was significantly inhibited. In summary, the study provided the novel insight of a competitive endogenous RNA regulatory network for IMF content in pig, and our results indicated that SCML4 is likely to be a regulatory gene promoting IMF formation. - Source: PubMed
Tian ZheLi WenwenYu MubinWang TaoRuan GuiliLi AiyingZhang ShuerZhang MinZhai XiangweiCheng ShunfengShen WeiWang Junjie - Y. Tang and X. Li, "Role and Mechanism of Circ-PDE7B in the Formation of Keloid," International Wound Journal 20, no. 9 (2023): 3738-3749, https://doi.org/10.1111/iwj.14269. The above article, published online on 08 June 2023 in Wiley Online Library (http://onlinelibrary.wiley.com/), and its corrigendum (https://doi.org/10.1111/iwj.14869), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons, Ltd. The original published article did not include details about the location for sample collection and details about the organization which provided ethical approval for the study. In addition, individuals other than the authors were included in the author contributions statement, which casts doubt about the origins of the research and authorship for this article. A corrigendum was published on 25 April 2024 (https://doi.org/10.1111/iwj.14869) which stated that samples were collected at Xi'an Central Hospital and corrected the authorship contribution statement to include reference to the listed authors. However, no information regarding the ethical approval of the study was included. The authors did not respond to an inquiry by the publisher and a request for original data and ethics approval information. As such, the publisher is not able to verify the origins and veracity of the research presented in this article. The editors have therefore agreed to issue a retraction for the article. The authors did not respond to our notice regarding the retraction. - Source: PubMed
- Wooden Breast (WB) myopathy is one of the most challenging problems facing the broiler industry. Fibrosis characterized by extracellular matrix (ECM) proteins has been recorded as the prominent pathological feature within the pectoralis major muscles affected by WB. During the process of fibrosis, fibroblasts are the key players. Transforming growth factor-β1 (TGF-β1) serves as the principal cytokine inducing fibroblast to myofibroblast Transition (FMT). The mechanism of TGF-β in regulating fibroblast activation remains unclear despite growing evidence of its involvement. The objective of this study was to establish an in vitro chicken fibroblast activation model using TGF-β1 stimulation, and to explore the transcriptomic changes during this process. Results indicated that TGF-β1 upregulated the expression levels of FMT markers α-SMA, Collagen I, ACTA2, COL1A1, and FN1 in a dose-dependent and time-dependent manner (P < 0.05). Subsequently, RNA-seq analysis showed that a total of 1532 differentially expressed mRNAs (DEmRNAs) were identified between TGF-β1-induced chicken fibroblasts and the control group. We screened crucial biological processes and core DEmRNAs enriched in functional pathways, and established the protein-protein interaction network. Upregulated DEmRNAs including AMPD3, PDE10A and PDE4D, as well as downregulated DEmRNAs including NT5C1B, NT5M, ENTPD1, PDE1A, ADSL, DGUOK and PDE7B were identified as hub genes. Collectively, our current study provides a model framework for investigating the pathogenesis of WB myopathy and advances the mechanistic understanding of TGF-β1-induced fibrosis development in broiler chickens. - Source: PubMed
Publication date: 2025/07/16
Hou TaijiangZhang LinZhao LiangGao FengXing Tong - Preeclampsia (PE) is one of the leading causes of perinatal maternal and fetal morbidity and mortality, but its precise mechanism remains elusive. Previous research has suggested that c-Maf-inducible protein (CMIP) is abnormally expressed in PE pathophysiology. Therefore, we aimed to explore the potential role of CMIP and its downstream molecules in PE. - Source: PubMed
Publication date: 2025/05/15
Li YinaYan XinjingYu HaiyangZhou YuanboGao YongruiZhou XinyuanYuan YujieDing YangnanShi QianqianFang YangDu HongmeiYuan EnwuZhao XinZhang Linlin - : Phosphodiesterase 7 (PDE7), a member of the PDE superfamily, selectively catalyzes the hydrolysis of cyclic adenosine 3',5'-monophosphate (cAMP), thereby regulating the intracellular levels of this second messenger and influencing various physiological functions and processes. There are two subtypes of PDE7, PDE7A and PDE7B, which are encoded by distinct genes. PDE7 inhibitors have been shown to exert therapeutic effects on neurological and respiratory diseases. However, FDA-approved drugs based on the PDE7A inhibitor are still absent, highlighting the need for novel compounds to advance PDE7A inhibitor development. : To address this urgent and important issue, we conducted a comprehensive cheminformatics analysis of compounds with potential for PDE7A inhibition using a curated database to elucidate the chemical characteristics of the highly active PDE7A inhibitors. The specific substructures that significantly enhance the activity of PDE7A inhibitors, including benzenesulfonamido, acylamino, and phenoxyl, were identified by an interpretable machine learning analysis. Subsequently, a machine learning model employing the Random Forest-Morgan pattern was constructed for the qualitative and quantitative prediction of PDE7A inhibitors. : As a result, six compounds with potential PDE7A inhibitory activity were screened out from the SPECS compound library. These identified compounds exhibited favorable molecular properties and potent binding affinities with the target protein, holding promise as candidates for further exploration in the development of potent PDE7A inhibitors. : The results of the present study would advance the exploration of innovative PDE7A inhibitors and provide valuable insights for future endeavors in the discovery of novel PDE inhibitors. - Source: PubMed
Publication date: 2025/03/21
Li YuzeWang ZheMa ShengyaoTang XiaowenZhang Hanting