Ask about this productRelated genes to: PRLHR antibody
- Gene:
- PRLHR NIH gene
- Name:
- prolactin releasing hormone receptor
- Previous symbol:
- GPR10
- Synonyms:
- PrRPR
- Chromosome:
- 10q26.11
- Locus Type:
- gene with protein product
- Date approved:
- 1995-01-25
- Date modifiied:
- 2016-10-05
Related products to: PRLHR antibody
Related articles to: PRLHR antibody
- Automated milking systems (AMS) enable the generation of objective measurements of teat placement, a key factor influencing milking efficiency and udder health. In this context, we performed GWAS to investigate the genetic background of 2 teat placement traits, i.e., rear teat distance (RTD) and front teat distance (FTD), derived from Cartesian coordinates recorded by AMS in American Holstein cows. Phenotypic data were collected from 36 AMS robots, resulting in 4,232,026 records from 4,118 cows genotyped for 57,598 SNPs. The GWAS was performed using the POSTGSF90 software, with SNP effects estimated by back-solving genomic EBV, followed by calculation of approximate P-values. For RTD, we identified 7 chromosome-wise significant SNPs located on chromosomes BTA8, BTA9, and BTA26. These genomic regions overlap with strong candidate genes, including HTR1B, PRLHR, EMX2, and GRK5, which have been previously associated with milk production, growth, and muscular development. A total of 203 previously reported QTL were found in the BTA9 and BTA26 regions identified for RTD, indicating the complex genetic background of this trait. For FTD, 8 significant SNPs were identified on BTA2, BTA8, BTA18, and BTA28, encompassing key genes such as UBE2R2, UBAP2, and NLRP12. We identified 46 QTL overlapping with these regions, which were previously associated with traits such as susceptibility to bovine respiratory disease, length of productive life, and stayability. These results suggest a genetic link between teat spacing and cow health and longevity. Overall, our findings indicate a polygenic basis for both FTD and RTD, with numerous small-effect variants associated with teat placement. The identified genomic regions and candidate genes associated with these traits contribute to enhancing our understanding of the biological mechanisms underlying teat placement traits in American Holstein cattle. - Source: PubMed
Publication date: 2026/01/20
Medeiros Gabriel CFerraz Jose Bento SSousa Luis Paulo BMussi Camila SSuárez-Vega AroaPedrosa Victor BChen Shi-YiOliveira Hinayah RBrito Luiz F - : Emerging evidence suggests that biological sex shapes glioma biology and therapeutic response. : We performed a sex-stratified analysis of CGGA (Chinese Glioma Genome Atlas) RNA sequencing data comparing low-grade glioma (LGG) with high-grade glioma (HGG) and glioblastoma (GBM). Using the 3PodR framework, we integrated differential expression analysis with Gene Set Enrichment Analysis (GSEA), EnrichR, leading-edge analysis, and iLINCS drug repurposing. : These comparisons provide a proxy for biological processes underlying malignant transformation. In LGG vs. HGG, 973 significantly differentially expressed genes (DEGs) were identified in females and 1236 in males, with 15.5% and 33.5% unique to each sex, respectively. In LGG vs. GBM, 2011 DEGs were identified in females and 2537 in males, with 12.6% and 30.7% being unique. Gene-level contrasts included GLI1 upregulation in males and downregulation in females, GCGR upregulation in males, MYOD1 upregulation in females, and HIST1H2BH downregulation in males. Additional top DEGs included PRLHR, DGKK, DNMBP-AS1, HOXA9, CTB-1I21.1, RP11-47I22.1, HPSE2, SAA1, DLK1, H19, PLA2G2A, and PI3. In both sexes, LGG-HGG and LGG-GBM grade comparisons converged on neuronal and synaptic programs, with enrichment of glutamatergic receptor genes and postsynaptic modules, including GRIN2B, GRIN2A, GRIN2C, GRIN1, and CHRNA7. In contrast, collateral pathways diverged by sex: females showed downregulation of mitotic and chromosome-segregation programs, whereas males showed reduction of extracellular matrix and immune-interaction pathways. Perturbagen analysis nominated signature-reversing compounds across sexes, including histone deacetylase inhibitors, Aurora kinase inhibitors, microtubule-targeting agents such as vindesine, and multi-kinase inhibitors targeting VEGFR, PDGFR, FLT3, PI3K, and MTOR. : Glioma grade comparisons reveal a shared neuronal-synaptic program accompanied by sex-specific transcriptional remodeling. These findings support sex-aware therapeutic strategies that pair modulation of neuron-glioma coupling with chromatin- or receptor tyrosine kinase/angiogenic-targeted agents, and they nominate biomarkers such as GLI1, MYOD1, GCGR, PRLHR, and HIST1H2BH for near-term validation. - Source: PubMed
Publication date: 2025/12/24
Rami Reddy Madhu Vishnu Sankar ReddyWood Jacob FNorris JordanBecker KathrynMurphy Shawn CDoddi SishirImami AliRyan V William GNguyen JenniferSchroeder JasonEisenmann KathrynMcCullumsmith Robert E - (1) Glioblastoma (GBM) is one of the most aggressive brain tumors with a poor prognosis. Therefore, new insights into GBM diagnosis and treatment are required. In addition to differentially expressed mRNAs, miRNAs may have the potential to be applied as diagnostic biomarkers. (2) In this study, profiling of human miRNAs in combination with mRNAs was performed on total RNA isolated from tissue samples of five control and five GBM patients, using a high-throughput RNA sequencing (RNA-Seq) approach. (3) A total of 35 miRNAs and 365 mRNAs were upregulated, while 82 miRNAs and 1225 mRNAs showed significant downregulation between tissue samples of GBM patients compared to the control samples using the iDEP to analyze RNA-Seq data. To validate our results, the expression of five miRNAs (hsa-miR-196a-5p, hsa-miR-21-3p, hsa-miR-10b-3p, hsa-miR-383-5p, and hsa-miR-490-3p) and fourteen mRNAs (E2F2, HOXD13, VEGFA, CDC45, AURKB, HOXC10, MYBL2, FABP6, PRLHR, NEUROD6, CBLN1, HRH3, HCN1, and RELN) was determined by RT-qPCR assay. The miRNet tool was used to build miRNA-target interaction. Furthermore, a protein-protein interaction (PPI) network was created from the miRNA targets by applying the NetworkAnalyst 3.0 tool. Based on the PPI network, a functional enrichment analysis of the target proteins was also carried out. (4) We identified an miRNA panel and several deregulated mRNAs that could play an important role in tumor development and distinguish GBM patients from healthy controls with high sensitivity and specificity using total RNA isolated from tissue samples. - Source: PubMed
Publication date: 2025/03/19
Géczi DóraKlekner ÁlmosBalogh IstvánPenyige AndrásSzilágyi MelindaVirga JózsefBakó AndreaNagy BálintTorner BernadettBirkó Zsuzsanna - Several groups of neurons in the NTS suppress food intake, including Prlh-expressing neurons (NTS cells). Not only does the artificial activation of NTS cells decrease feeding, but also the expression of Prlh (which encodes the neuropeptide PrRP) and neurotransmission by NTS neurons contributes to the restraint of food intake and body weight, especially in animals fed a high fat diet (HFD). We set out to determine roles for putative PrRP receptors in the response to NTS PrRP and exogenous PrRP-related peptides. - Source: PubMed
Publication date: 2025/01/02
Wang YiQiu WeiweiKernodle StaceParker CarlyPadilla Marc-AntonioSu JiaaoTomlinson Abigail JOldham StephanieField JossBernard EliseHornigold DavidRhodes Christopher JOlson David PSeeley Randy JMyers Martin G - Japanese encephalitis virus (JEV) is a pathogen with a substantial impact on both livestock and human health. However, the critical host factors in the virus life cycle remain poorly understood. Using a library comprising 123411 small guide RNAs (sgRNAs) targeting 19050 human genes, we conducted a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based screen to identify essential genes for JEV replication. By employing knockout or knockdown techniques on genes, we identified eleven human genes crucial for JEV replication, such as prolactin releasing hormone receptor (PRLHR), activating signal cointegrator 1 complex subunit 3 (ASCC3), acyl-CoA synthetase long chain family member 3 (ACSL3), and others. Notably, we found that PRLHR knockdown blocked the autophagic flux, thereby inhibiting JEV infection. Taken together, these findings provide effective data for studying important host factors of JEV replication and scientific data for selecting antiviral drug targets. - Source: PubMed
Publication date: 2024/04/24
Liu Le-leYin You-QinMa Kai-XiongXing Jin-ChaoRen Xing-XingHuang Jin-YuLiao MingQi Wen-BaoHuang Li-Hong