Ask about this productRelated genes to: CERK antibody
- Gene:
- CERK NIH gene
- Name:
- ceramide kinase
- Previous symbol:
- -
- Synonyms:
- hCERK, FLJ23239, dA59H18.3, DKFZp434E0211, FLJ21430, KIAA1646, LK4, dA59H18.2
- Chromosome:
- 22q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2002-10-09
- Date modifiied:
- 2018-03-13
Related products to: CERK antibody
Related articles to: CERK antibody
- Ovarian cancer (OV) is the leading cause of mortality among gynecological malignancies, often diagnosed at an advanced stage and prone to recurrence after treatment. In order to improve the prognosis, there is an urgent clinical need to identify novel strategies for early intervention and prognosis prediction. Sphingolipids are both important components of cell membranes and closely related to cell signaling. Key enzymes and intermediates of sphingolipid metabolism have critical roles in regulating biological processes such as proliferation and apoptosis of cancer cells, and some of the anticancer drugs targeting sphingolipid metabolism have already entered into clinical trials. However, the prognostic value of sphingolipid metabolism-related genes (SRGs) in OV remains unclear. This study aims to systematically evaluate the prognostic significance of SRGs in OV and construct a prognostic risk model to improve survival prediction. - Source: PubMed
Publication date: 2026/02/26
Lian XinChang HaoYang YunGuo YichenZhang LeiJia Xuemei - Post-traumatic Deep vein thrombosis (pt-DVT) is a serious health issue that often leads to considerable morbidity and mortality especially in patients with coronary heart disease (CHD). Diagnosis of DVT in a clinical setting, however, presents considerable challenges. Multiomics techniques has led to high diagnostic and prognostic accuracy for various pathological conditions. - Source: PubMed
Publication date: 2026/03/28
Aliyu MukhtarZhang KunHuang WeiGu JinshanXue HanzhongLi ZhongLin HuaGuo Yan - Ceramide kinase (CerK) catalyzes the phosphorylation of ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid with diverse signaling roles. While CerK has been identified in several cellular compartments, its presence and functional significance in kidney proximal tubules remain unexplored. Herein, we report the first characterization of CerK activity in basolateral membranes (BLMs) from porcine proximal tubule cells. We demonstrate that BLM fractions contain neutral and acidic sphingomyelinases, providing local substrate for CerK, which efficiently generates C1P under physiological pH (6.5-7.2) and temperature (30-37 °C) conditions. Enzyme activity was stimulated by cAMP in a protein kinase A-dependent manner but was not affected by angiotensin II. Lipidomic analysis confirmed the presence of C1P in human proximal tubule (HK-2) cells under basal conditions and revealed changes during ischemic stress. Transcriptomic analysis of kidney biopsies from patients with chronic kidney disease (CKD) further uncovered coordinated remodeling of sphingolipid metabolism genes, with increased expression of ceramidases (ASAH1 and NAAA) and downregulation of ceramide synthases (CERS4, CERS5), consistent with adaptive regulation of the Cer/CerK/C1P axis. Together, these findings identify for the very first time CerK activity in renal BLM, establish its biochemical requirements, and highlight its potential role in modulating transporter function and sphingolipid signaling in physiology and kidney disease. - Source: PubMed
Publication date: 2025/10/24
Grelle Gloria M R SCabral Lindsey M PAlmeida Fernando GTortelote Giovane GGarrett RafaelVieyra AdalbertoValverde Rafael H FCaruso-Neves CelsoEinicker-Lamas Marcelo - Sphingolipids are bioactive lipids that are essential for cellular functions like signaling, apoptosis, and proliferation. They are also important in the biology of cancer. The complex dynamics of sphingolipid metabolism and its consequences for the advancement of cancer are examined in this review. It highlights the regulatory functions of important enzymes such as ceramide kinase (CERK) and sphingosine kinases (SPHKs) in preserving the equilibrium between sphingosine-1-phosphate (S1P), a pro-survival chemical, and ceramides, which encourage cell death. Tumour growth, metastasis, and treatment resistance are all significantly affected by disturbances in this equilibrium. The review emphasizes the potential of sphingolipids as biomarkers for cancer prognosis and stratification, providing information on the course of the disease and the effectiveness of treatment. Their crucial functions in cellular signalling pathways that affect angiogenesis, immunological evasion, and drug resistance, all of which are linked to cancer, are also reviewed. Their role in the tumor microenvironment further highlights sphingolipids' significance as targets for novel therapeutic approaches. Improved clinical results and personalized cancer treatments are made possible by developments in sphingolipid biology and their potential as biomarkers. This thorough synthesis provides the groundwork for further studies that will use sphingolipid metabolism and signalling to create potent cancer treatments. In the fight against cancer, we can improve therapeutic efficacy and diagnostic accuracy by understanding these intricate relationships. - Source: PubMed
Desai Sharav ANagare Sandip DPatel Vipul PPagare Nishant BJangam Tejas C - Strabismus has been described since antiquity and was attributed to obscure phenomena or anatomical anomalies. The aim of this article is to examine the evolution of knowledge about strabismus and the treatments used to manage it over the centuries. This review helps us to understand how modern approaches emerged. - Source: PubMed
Publication date: 2025/09/16
Jurkiewicz Tristan