Ask about this productRelated genes to: SPHK1 antibody
- Gene:
- SPHK1 NIH gene
- Name:
- sphingosine kinase 1
- Previous symbol:
- -
- Synonyms:
- SPHK
- Chromosome:
- 17q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-01
- Date modifiied:
- 2015-08-26
Related products to: SPHK1 antibody
Related articles to: SPHK1 antibody
- Zhenwu decoction (ZWD), from the Treatise on Febrile Diseases, has been used in Chinese medicine for "kidney yang deficiency with water retention". Metabolic reprogramming has been recognized as a critical driver of renal inflammation and fibrosis in chronic kidney disease (CKD). However, whether ZWD exerts its renoprotective effects by reversing this metabolic disturbance remains unclear. - Source: PubMed
Publication date: 2026/08/13
Cao YiwenLiao YonganLong ZiyuMa JiayiJiang HuilianZeng ZhijunWang SiyiSu YingruLiang ChunlingWu JunbiaoZhou YuanZhou Jiuyao - Despite direct-acting antiviral (DAA) therapies achieving sustained virologic response (SVR) rates exceeding 95%, hepatocellular carcinoma (HCC) risk persists in cured hepatitis C virus (HCV) patients, particularly those with advanced fibrosis or concurrent metabolic dysfunction-associated steatotic liver disease (MASLD). This clinical paradox implies that HCV induces durable oncogenic molecular alterations independent of active viral replication, fundamentally challenging the notion that virologic cure equates to biological liver cure. This review aims to delineate the molecular mechanisms underlying this residual risk and to identify rational targets for chemoprevention in the post-SVR era. - Source: PubMed
Publication date: 2026/05/15
Le Duong Hoang HuyNilyanimit PornjarimHonsawek SittisakPoovorawan Yong - Sphingosine-1-phosphate (S1P) signaling has emerged as a regulator of metabolic homeostasis, but its relationship to brown adipose tissue (BAT) adaptation across physiological conditions remains unclear. We examined how S1P-related gene expression in BAT and subcutaneous white adipose tissue (scWAT) varies with acute exercise, chronic exercise, ambient temperature, aging, sex, and UCP1 deficiency. Young and aged wild-type mice, as well as aged UCP1 knockout (UCP1KO) mice, were studied across acute or chronic exercise paradigms and thermal conditions ranging from 4 °C to 30 °C. In BAT, acute exercise was associated with lower , , and expression in young females, whereas aged males showed lower and after exercise. In scWAT, exercise-associated induction of S1P-related transcripts was most evident in aged males. Female BAT also displayed broader temperature- and chronic exercise-associated differences in , , and β-adrenergic receptor transcripts, whereas male BAT showed fewer transcriptional changes. In UCP1KO mice, these exercise-associated patterns were altered or attenuated. Together, these findings identify a context-dependent adipose S1P-related transcriptional program that differs by sex, age, depot, ambient temperature, exercise condition, and UCP1 status. - Source: PubMed
Publication date: 2026/07/27
Ozabrahamyan SerenaNirengi ShinsukeVidal PabloBaer Lisa AStanford Kristin I - Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide. Tumor angiogenesis plays a crucial role in breast cancer progression, making angiogenesis-associated pathways attractive therapeutic targets. Computational drug discovery approaches, including virtual high-throughput screening (VHTS), molecular docking, molecular dynamics simulations, and binding free energy calculations, have emerged as valuable tools for identifying and optimizing anticancer compounds. This review evaluates the application of these computational techniques in the discovery of antiangiogenic therapeutic candidates for breast cancer. - Source: PubMed
Publication date: 2026/08/12
Singh RobinGupta NehaLuxmi Raj - The discovery of potential targets in Head and neck squamous cell carcinomas (HNSCC) through molecular and mechanism analyses is crucial for understanding and treating this disease. This study utilized rigorous methods, including cell lines (FaDu and SCC-15) and a xenograft tumor model. Transfections were conducted using the Lipofectamine 2000 kit, and the evaluation of HOXC11, SPHK1, apoptosis-related protein, and the Wnt signaling pathway was carried out using qPCR and WB methods. The cell proliferation, migration, invasion, and apoptosis were comprehensively evaluated using colony formation, Transwell, wound healing, and flow cytometry, respectively. HOXC11 and SPHK1 are highly expressed in HNSCC and might be involved in the Wnt signaling pathway. HOXC11 promoted cell proliferation, migration, and invasion, inhibiting apoptosis in HNSCC. Silencing SPHK1 inhibited cell progression and dysregulated the Wnt signaling pathway in HNSCC. Overexpressed SPHK1 reversed the functions of sh-HOXC11 in regulating cell progression and the Wnt signaling pathway. HOXC11 promotes HNSCC progression by regulating SPHK1 through the Wnt signaling pathway. Silencing HOXC11 inhibited the tumor growth of HNSCC. Our study demonstrates that HOXC11 promotes HNSCC progression by regulating SPHK1 through the Wnt/β-catenin signaling pathway, identifying a previously unrecognized regulatory axis in HNSCC. - Source: PubMed
Publication date: 2026/07/25
Zhang JingWu QionghuiLiu JingyuanLi Shisheng