Ask about this productRelated genes to: DKK1 antibody
- Gene:
- DKK1 NIH gene
- Name:
- dickkopf WNT signaling pathway inhibitor 1
- Previous symbol:
- -
- Synonyms:
- SK, DKK-1
- Chromosome:
- 10q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-01
- Date modifiied:
- 2018-06-28
Related products to: DKK1 antibody
Related articles to: DKK1 antibody
- Osteocytes, once viewed mainly as passive bone-embedded cells, are now recognized as active regulators of the metastatic bone niche. Emerging evidence indicates that these cells integrate mechanical, inflammatory, and tumor-derived cues to influence metastatic seeding, dormancy, reactivation, and lesion progression in bone. This review synthesizes current understanding of osteocyte contributions to skeletal metastasis. We discuss core signaling axes, including osteocyte-derived RANKL/OPG balance, Wnt antagonists (sclerostin/DKK1), mechanotransduction pathways (Piezo1 signaling and connexin-43 hemichannels), and osteocyte paracrine mediators (extracellular vesicles and senescence-associated factors), and examine how each axis modulates tumor cell dormancy, osteolysis, or osteoblastic progression. We then review translational strategies targeting osteocytes, recent preclinical and clinical insights. Emerging biomarkers (e.g., serum sclerostin, DKK1, bone turnover markers) and immune-skeletal imaging approaches are also considered. Controversies, including the paradoxical effects of sclerostin blockade and the identity of in vivo RANKL sources, are discussed. Finally, we outline key knowledge gaps and propose endpoints for future trials. In summary, an osteocyte-centric perspective reveals novel targets and strategies for managing bone metastases, guiding future translational research. - Source: PubMed
Publication date: 2026/04/20
Dabaliz AlhomamBakir MohamadFatash LanaAldoush MaisMohammad Khalid Said - : This study aimed to evaluate associations between dental caries, periodontal pockets, and radiologically detected periapical lesions in relation to serum levels of Dickkopf-1 (Dkk-1) and tartrate-resistant acid phosphatase 5B (TRAP-5B) in oncologic patients with ear, nose, and throat (ENT) cancer compared with healthy controls. : The study included 63 subjects divided into a study group of 33 patients diagnosed with ENT cancer and a control group of 30 healthy individuals. Blood samples were collected to assess serum Dkk-1 levels using a sandwich enzyme immunoassay and TRAP-5B levels. Radiological dental evaluation included orthopantomography (OPT) and cone beam computed tomography (CBCT) to assess the number and depth of dental caries and the presence of periapical lesions. Periodontal pockets were recorded through clinical examination. : Serum biomarker analysis demonstrated significant differences between groups: TRAP-5B levels were significantly higher in patients with ENT cancer, whereas Dkk-1 concentrations were significantly lower compared with healthy controls ( < 0.001). OPT revealed up to eight carious lesions in both groups. The mean number of carious lesions was higher in healthy subjects (2.97 ± 2.48) than in patients with ENT cancer (2.06 ± 2.29). CBCT evaluation revealed 0-8 carious lesions in healthy individuals and 0-6 lesions in patients with ENT cancer, with a significantly higher mean number of lesions in the control group (2.97 ± 2.48 vs. 1.85 ± 1.89). Periodontal pockets were more frequent in patients with ENT cancer (0.67 ± 1.32) than in controls (0.37 ± 0.81). OPT evaluation also showed a higher mean number of periapical lesions in patients with ENT cancer (0.82 ± 1.29) compared with controls (0.37 ± 0.67). CBCT examination demonstrated that the mean number of periapical lesions in patients with ENT cancer was more than twice that of the control group, although this difference did not reach statistical significance. : Patients with ENT cancer exhibited significantly altered systemic bone turnover biomarker profiles, characterized by increased TRAP-5B and decreased Dkk-1 levels. Clinically, these patients also presented a higher prevalence of periodontal pockets and periapical lesions, whereas carious lesions were more frequently detected in healthy individuals. The combined radiological and biochemical findings contribute to a better understanding of oral-systemic interactions in oncologic patients and highlight the importance of comprehensive dental evaluation prior to oncologic therapy. - Source: PubMed
Publication date: 2026/04/01
Antohi CristinaCernei Eduard RaduSolomon SorinaConcita Alexandra CorinaPopescu Roxana MihaelaSalceanu Mihaela - : Sclerostin or dickkopf-1 (DKK1) inhibits the canonical Wnt/β-catenin signaling pathway, which regulates vascular calcification and may contribute to the development of arterial stiffness. The brachial-ankle pulse wave velocity (baPWV) measures peripheral arterial stiffness (PAS). This study aimed to investigate the correlation between sclerostin and DKK1 levels and PAS in patients with type 2 diabetes mellitus (T2DM). : Biochemical data and sclerostin and DKK1 levels were analyzed in the fasting blood samples of 125 patients with T2DM. baPWV measurements using the VaSera VS-1000 automatic pulse wave analyzer classified patients with values > 18.0 m/s on either side into the PAS group. : Among patients with T2DM, 47 (37.6%) were classified as having PAS. These patients exhibited higher hypertension prevalence ( = 0.002); greater age ( < 0.001); elevated systolic ( < 0.001) and diastolic blood ( = 0.012) pressures; and increased fasting glucose ( = 0.001), glycated hemoglobin ( = 0.008), triglyceride ( = 0.001), blood urea nitrogen ( < 0.001), and creatinine ( = 0.001) levels, urine albumin-to-creatinine ratio ( = 0.039), and C-reactive protein ( = 0.024) and serum sclerostin ( < 0.001) levels, but decreased estimated glomerular filtration rate ( < 0.001). Multivariate logistic regression analysis identified serum sclerostin level (odds ratio, 1.127; 95% confidence interval, 1.058-1.200; < 0.001) as an independent PAS predictor in patients with T2DM. Serum log-transformed sclerostin levels were positively correlated with left ( = 0.005) and right ( = 0.001) baPWV via Spearman's rank-order correlation coefficient analysis. : Serum sclerostin levels, but not DKK1 levels, are positively correlated with PAS in patients with T2DM. - Source: PubMed
Publication date: 2026/03/27
Hsu Bang-GeeLi Jer-ChuanWu Du-AnChen Ming-Chun - Osteoarthritis (OA) is the most prevalent degenerative joint disorder worldwide, characterized by impaired anabolic activity and excessive catabolic responses in chondrocytes. However, the precise mechanisms governing chondrocyte homeostasis during OA progression remain unclear. - Source: PubMed
Publication date: 2026/05/01
Zhang Xiao-FeiZhang Bo-WenWu FanWang Zi-XuanPan Wen-MingCao Chu-YiLv Xin-YuRen Tian-XingXu Wei-HuaWang HuiZhang Jin-Xiang - This study examined the effects of resistance exercise versus interval running on post-exercise concentrations of bone metabolic markers in postmenopausal females. - Source: PubMed
Publication date: 2026/04/27
Guisado-Cuadrado IsabelRomero-Parra NuriaBell MadisonElliott-Sale Kirsty JSale CraigKlentrou PanagiotaPeinado Ana B