Ask about this productRelated genes to: DKK1 antibody
- Gene:
- DKK1 NIH gene
- Name:
- dickkopf WNT signaling pathway inhibitor 1
- Previous symbol:
- -
- Synonyms:
- SK, DKK-1
- Chromosome:
- 10q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-01
- Date modifiied:
- 2018-06-28
Related products to: DKK1 antibody
Related articles to: DKK1 antibody
- Intervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, imposing a significant economic and physiological burden on individuals and society worldwide. Although dysregulation of the WNT/β-catenin pathway is considered an important factor contributing to the dysfunction of nucleus pulposus (NP) cells and degradation of the extracellular matrix, the mechanisms by which specific subgroups of NP cells are activated and the maintenance of excessive activation of specific pathways remain unclear. - Source: PubMed
Publication date: 2026/08/22
Li QiuweiLiang GuoyanBo KaidaKang LiangJin PeilinZhao ChenhaoZhang RenjieLyu FengjuanShen Cailiang - Secreted modulators of the Wingless (WNT) pathways are associated with cardiometabolic dysregulation. Among these, Dickkopf-1 (DKK1) and secreted frizzled-related protein-3 (sFRP3) are abundantly expressed in placental tissue and secreted into the maternal circulation. We hypothesized their plasma levels would be dysregulated in women with gestational diabetes mellitus (GDM) and correlate with indices of metabolic health. - Source: PubMed
Publication date: 2026/08/14
Ueland ThorMichelsen Annika ElisabetQvigstad ElisabethRoland Marie Cecilie PaascheWesterberg Ane CecilieMichelsen Trond MelbyeAukrust PålBollerslev JensLekva Tove - Following the publication of the above paper, the authors contacted the Editorial Office to explain that they had incorrectly assembled certain of the data included in the western blots featured in Fig. 2D on p. 1033, and wished to issue a corrigendum. Upon performing an independent analysis of the data in this paper in the Editorial Office, however, it came to light that the data in question were strikingly similar to data which had already been submitted to the same journal () in a paper written by different authors at a different research institute. Upon asking the authors for an explanation concerning these data, the authors presented to the office a series of blots related to the same experiments, including the purported integral blots associated with the published data. However, owing to a number of remaining uncertainties concerning the blots provided resulting from an additional assessment of the raw underlying data made using the software analysis program, the Editor of has decided that this paper should be retracted from the Journal on account of a lack of confidence in the originally presented data. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Molecular Medicine 46: 1029‑1038, 2020; DOI: 10.3892/ijmm.2020.4672]. - Source: PubMed
Publication date: 2026/08/28
Liu JunWu MinfeiFeng GuangLi RuiWang YangJiao Jianhang - Semen quality is a critical determinant of reproductive efficiency in poultry, yet its molecular regulation remains poorly understood. - Source: PubMed
Publication date: 2026/08/12
Zhang LeiSun GuoboZhu RuiLi XiaomingZhang GanshengDuan Xiujun - Achondroplasia is the most common genetic skeletal dysplasia associated with disproportionate short stature and is primarily caused by gain-of-function variants in the fibroblast growth factor receptor 3 (FGFR3) gene. Constitutive FGFR3 activation disrupts growth plate homeostasis and endochondral ossification through complex alterations in chondrocyte proliferation, differentiation, hypertrophy, extracellular matrix organization, and intracellular signaling. The increasing understanding of these mechanisms has enabled the transition from exclusively supportive management toward disease-modifying and precision-based therapeutic strategies. This narrative review aimed to critically synthesize current evidence on the genetic basis, molecular pathogenesis, growth plate abnormalities, and current and emerging targeted therapies in achondroplasia. - Source: PubMed
Publication date: 2026/08/21
Șerban Rebecca CristianaMitut-Veliscu AndreeaDumitra AlexandraMarica LianaPopescu CristinaCostache AndreiTeona ȘerbanRiza Anca-LeliaDirnu RodicaVarut Renata-MariaStreață Ioana