Ask about this productRelated genes to: BRS3 antibody
- Gene:
- BRS3 NIH gene
- Name:
- bombesin receptor subtype 3
- Previous symbol:
- -
- Synonyms:
- BB3, BB3R
- Chromosome:
- Xq26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2016-06-07
Related products to: BRS3 antibody
Related articles to: BRS3 antibody
- The parabrachial nucleus (PBN) is a critical hub for pain processing that acts as a switchboard for nociceptive signals, relaying sensory information to forebrain regions that integrate the sensory and affective dimensions of pain. Although the PBN is well established as a key regulator of pain, the remarkable heterogeneity of its neuronal populations has hindered efforts to identify specific cell types responsible for distinct aspects of pain processing. Here, we identify bombesin receptor subtype 3 ()-expressing neurons as a distinct glutamatergic PBN subpopulation involved in heat hypersensitivity associated with persistent pain. Using expression analysis and calcium imaging, we demonstrate that neurons exhibit heightened activity in response to heat stimulation following an inflammatory insult or neuropathic injury. Inhibition of neurons effectively reduces heat, but not mechanical, hypersensitivity induced by both inflammatory and neuropathic pain, suggesting a specific role in processing heat hypersensitivity. Ablation of parabrachial neurons prior to induction of pain also selectively prevents the development of heat hypersensitivity induced by persistent inflammation in mice. -expressing neurons encompass multiple previously identified pain-related PBN subpopulations, including those expressing the mu opioid receptor (), tachykinin 1 receptor (), and neuropeptide Y Y1 receptor (), positioning as a potential unifying marker of heat hypersensitivity circuits. These findings provide new insight into the organization of pain-processing networks in the PBN and highlight neurons as a crucial population for heat pain. - Source: PubMed
Publication date: 2026/07/20
Allen Heather NRodríguez-Palma Erick JNelson Tyler SGrabus Naomi KDufeal Nia AKhanna Rajesh - This study characterized the joint-specific time course of upper-limb spasticity to identify predictors of subsequent spasticity progression in post-stroke patients undergoing inpatient rehabilitation in a convalescent (Kaifukuki) rehabilitation ward (KRW). - Source: PubMed
Publication date: 2026/06/27
Tamashiro HiroakiUrushidani NaokiOkita KeikoOkamoto Takatsugu - : High recurrence rates and intensive lifelong surveillance make bladder cancer among the costliest malignancies to treat. Although Bacillus Calmette-Guérin (BCG) immunotherapy is the standard treatment for high-risk non-muscle-invasive bladder cancer (NMIBC), up to 50% of patients fail to respond, and predictive biomarkers are lacking. Molecular profiling has established three BCG response subtypes (BRS1-3), with BRS3 characterized by an immunosuppressive, BCG-resistant phenotype; however, these features have not been validated at single-cell spatial resolution. : We applied imaging mass cytometry (IMC) to 82 BCG-treated high-risk NMIBC samples and performed (i) single-cell IMC with unsupervised clustering to identify phenotypic cell clusters and quantify cluster abundances and (ii) a convolutional neural network-based gated attention multiple instance learning model trained on IMC images (IMC-GA-MIL) to predict BCG response. Cluster abundances were summarized using II (immune composition within the immune compartment), TT (tumor phenotypic composition), and IT (immune/stromal abundance relative to tumor cells) indices. : Single-cell IMC identified 18 distinct phenotypic cell clusters. In BCG responders, immune cells localized within the tumor compartment were enriched and independently protective (HR 0.67, 95% CI 0.49-0.92). BCG nonresponse was associated with a higher abundance of fibroblast-dominant clusters relative to tumor cells (IT index). Plasma cell-dominant clusters were the strongest predictors of progression (II index HR 2.28, 95% CI 1.37-3.79; IT index HR 1.25, 95% CI 1.06-1.48). The IMC-GA-MIL model predicted BCG response with 90% accuracy (9/10) and identified myeloid- and T-cell-associated marker patterns involving CD14, CD11b, CD68, CD8, and FOXP3 as the most informative contributors. : Spatial single-cell profiling and IMC-GA-MIL identify spatial immune and stromal features associated with BCG failure. However, findings from both analyses should be considered exploratory and will require validation in larger, independent cohorts. - Source: PubMed
Publication date: 2026/03/13
Lillesand MelindaAustdal MarieMroz JakubSkaland IvarGudlaugsson EinarJong Florus C deZuiverloon Tahlita C MEngan KjerstiJanssen Emiel A M - The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1 and 29 GABAergic neuron populations from the PVH and surrounding areas. Additionally, projection-based profiling identified neurons that project to the parabrachial region (PB) and spinal cord, helping to determine PVH populations that regulate satiety and sympathetic nervous system activity, respectively. Notably, activation of PB-projecting PVH neurons expressing Brs3 reduces food intake, and silencing them causes obesity. Together, this atlas contributes high-resolution PVH spatial and circuit-based gene expression profiles, representing a valuable resource for the field of homeostasis. - Source: PubMed
Publication date: 2026/01/23
Li YuxiButler Trevor CNardone StefanoJacobs Christopher LDouglass Amelia MMadara Joseph CMcDonough Miriam CTao JenkangLowenstein Elijah DWang LuhongPant DeeptiWalker Samuel JWang AnnetteSrinivasan HariniYang ZongfangCampbell John NTsai Linus TLowell Bradford BResch Jon M - Fever or inflammation state may enhance the Brugada syndrome (BrS) phenotype in some but not all patients. However, the underlying mechanism in human cardiomyocytes has not yet been clarified. - Source: PubMed
Publication date: 2025/12/01
Li YingruiRose LenaPrädel TimoKleinsorge MandyFan XuehuiMeng ZenghuiYan ChenLiu RuiLei XinhaoZhao BinyiYang GuoqiangLiao ZhenxingDinkel HendrikBusley Alexandra ViktoriaZhong RujiaZhang FengXu QiangMaywald LasseAweimer AssemHuang MengyingMoscu-Gregor AlexanderHamdani NazhaSchneider LucaZemedi YeweynwuhaZhazykbayeva SaltanatHohn AlyssaYang ZhenQiao LinMügge AndreasCyganek LukasZhou XiaoboAkin IbrahimEl-Battrawy Ibrahim