Ask about this productRelated genes to: GPR171 antibody
- Gene:
- GPR171 NIH gene
- Name:
- G protein-coupled receptor 171
- Previous symbol:
- -
- Synonyms:
- H963
- Chromosome:
- 3q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-12
- Date modifiied:
- 2016-05-09
Related products to: GPR171 antibody
Related articles to: GPR171 antibody
- A 52-year-old man presented with sarcomatoid diffuse pleural mesothelioma that had relapsed at an isolated site after a complete response to dual-immune checkpoint inhibition (ICI). Targeted sequencing exhibited amplification of chromosome 9p24, encompassing JAK2, PD-L1, PD-L2, and PTPRD in the relapsed (post-ICI) tumor, compared with baseline (pre-ICI). On multiplex immunofluorescence, tumor-associated macrophages (TAMs) and CD8 cytotoxic T lymphocytes (CTLs) made up most of the cells in baseline and relapsed tumor (59% and 47%, respectively). Baseline tumor cells expressed genes linked to extracellular matrix remodeling and epithelial-mesenchymal transition, intermixed with M2-like TAMs and tissue-resident, effector-like CTLs. Relapsed tumor cells shifted to a growth factor-driven phenotype (NT5E, NOD1, GATA2, FN1, PDCD1LG2) that is known to cause functional impairment of CTLs, which then transitioned to an exhausted state (FCRL3, CST7, GPR171, TRAT1, LAG3); exhausted CD8 and CD4 T cells are seen in the peripheral blood at relapse. TAMs were enriched in antigen-presentation (CD80, CD86, CXCL10), extracellular matrix-degradation (MMP9, CTSL), and CTL-suppression (ARG1, PLA2G7) pathways. Our analyses revealed that regional immunosuppression mediated by adaptive reprogramming of tumor-cell and immune-cell (TAMs, CTLs)-intrinsic changes-rather than by immune evasion or stromal exclusion-served as a mechanism of acquired resistance to dual-ICI therapy. - Source: PubMed
Publication date: 2026/04/15
Ollila HelyKulkarni PrateekKim HyojinAnkola PratitiChintala Navin KThomas CarlosSauter Jennifer LOffin MichaelAdusumilli Prasad S - Although IFI44 is recognized for its crucial role in autoimmune disorders, its function in breast cancer (BC) remains unclear. This study aimed to investigate the immune-related and prognostic significance of IFI44 in BC. - Source: PubMed
Publication date: 2026/04/08
Wu JiahuiYi WangLiu MengtingLi YingliangZhou BoxuanWu ZiyunCao WeiShi QingfengCai XiangkaiXiong Haiwei - Graft-versus-host disease (GVHD), a major adverse event following allogeneic hematopoietic stem cell transplantation (allo-HSCT), commonly affects leukemia patients and is associated with reduced survival and impaired quality of life. Early prediction of GVHD remains a major clinical challenge. - Source: PubMed
Publication date: 2026/03/12
Lu WeiHe ZhipengHuang Xianbao - Hematopoietic stem cells (HSCs), which sustain lifelong blood cell production, emerge from hemogenic endothelium during embryonic development through the regulation of multiple signaling pathways. However, generating functional HSCs in vitro remains challenging, underscoring gaps in understanding the underlying mechanisms. Here, we identify GPR171, a P2Y-family G-protein-coupled receptor (GPCR), as a critical regulator of vertebrate embryonic HSC specification. is highly expressed in hemogenic endothelium and hematopoietic stem and progenitor cells. A deficiency in Gpr171 results in severe embryonic HSC deficits but does not impair vasculogenesis and primitive hematopoiesis. We further find that its endogenous ligand, coded by , cooperates with Gpr171 to enhance HSC generation. Mechanistically, Gpr171 activates ERK1/2 and Notch signaling pathways independently and synergistically to promote HSC generation. Pharmacological treatment of zebrafish embryos with the human GPR171 ligand BigLEN significantly increases HSC numbers. Moreover, GPR171 signaling is evolutionarily conserved, as GPR171-deficient murine embryos also exhibit a significant reduction in functional HSCs. Overall, our findings reveal GPR171 as an evolutionarily conserved regulator of embryonic HSC specification and suggest its potential for translational applications in stem cell-based therapeutics. - Source: PubMed
Publication date: 2026/01/23
Zhou KunLiu HongyanZhu KaiYu LonghaiXu Peng-FeiLi Yan - Preterm infants have the highest incidence of late-onset sepsis, which could result in life-long morbidity, neurodevelopmental disability, and even death. We aimed to explore the anti-infection role of immune cells in treating preterm sepsis. - Source: PubMed
Publication date: 2025/10/28
Wang ShengquanLiu JiXu RongrongZhang WeihongMaimaitituerxun AnaerguliAximu AlimaWu JiaMa Jiawei