Ask about this productRelated genes to: SHBG antibody
- Gene:
- SHBG NIH gene
- Name:
- sex hormone binding globulin
- Previous symbol:
- -
- Synonyms:
- ABP, TEBG, MGC126834, MGC138391
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-14
- Date modifiied:
- 2016-04-04
Related products to: SHBG antibody
Related articles to: SHBG antibody
- Tamoxifen reduces breast cancer incidence and recurrence, but uptake for primary prevention remains limited, largely because of concerns regarding adverse effects at the standard 20 mg dose. Understanding systemic endocrine effects of lower tamoxifen doses may help improve future prevention strategies. - Source: PubMed
Publication date: 2026/09/10
Nash StephenHammarström MattiasThörngen John-OlofWinqvist OlaEliasson ErikBäcklund MagnusEriksson MikaelMargolin SaraThorén LindaBorgquist SigneCzene KamilaHall PerGabrielson Marike - Perfluorooctanoic acid (PFOA), a pervasive environmental pollutant, has been implicated in hepatic injury and metabolic dysfunction. However, its role as an environmental risk factor in the pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains incompletely understood, particularly from a systems biology perspective. - Source: PubMed
Publication date: 2026/09/09
Zhang TianyuYuan YuLin ChunliSong ChaoLiao TianrongSun YuewenTang Hongzhen - Evidence linking dietary protein intake with testosterone and sex hormone-binding globulin (SHBG) is limited. We examined these associations in 2,546 Finnish men aged 42-60 years using 4-day food records and multivariable-adjusted models. Higher total and animal protein intakes and a higher animal-to-plant protein ratio were associated with lower total testosterone and SHBG, whereas plant protein intake was positively associated with both. In the highest versus lowest animal protein quartile, total testosterone was 1.2 nmol/L lower (95% CI: 0.37-2.03) and SHBG 3.0 nmol/L lower (95% CI: 1.34-4.66). In the highest versus lowest plant protein quartile, total testosterone was 1.1 nmol/L higher (95% CI: 0.34, 1.93) and SHBG 3.0 nmol/L higher (95% CI: 1.06, 4.94). Free testosterone was inversely associated with the animal-to-plant protein ratio and positively with non-grain plant protein. These cross-sectional findings suggest opposite associations of animal and plant protein intakes with total testosterone and SHBG. - Source: PubMed
Publication date: 2026/09/09
Wynne-Ellis Miika MVirtanen Heli E KBertone-Johnson ElizabethHantunen SariTuomainen Tomi-PekkaSalonen Jukka TVirtanen Jyrki K - The recurrence of breast cancer is a significant concern for survivors of the disease. This study aimed to examine the impact of 16 weeks of home-based combined exercise training (HET) and aerobic exercise training (AE) on biological markers related to breast cancer and physical function in breast cancer survivors. - Source: PubMed
Publication date: 2026/09/07
Jamali ParisaAlizadeh RostamAmiri EhsanRezaeinezhad Najmeh - Organophosphate esters (OPEs) may disrupt hormonal balance, but their specific effects in pre- and post-menopausal women have been underexplored. This investigation delves into the menopause-specific associations of OPEs with sex hormones in the National Health and Nutrition Examination Survey, 2013-2016. We included 817 premenopausal and 657 postmenopausal women. Survey-weighted multivariable linear regression, restricted cubic splines (RCS), principal component analysis (PCA), and quantile-based g computation (qgcomp) models were conducted to investigate the associations of OPE metabolites and OPEs mixture with sex hormones in pre- and postmenopausal women. In postmenopausal women, bis(2-chloroethyl) phosphate (BCEP) and Bis(1,3-dichloro-2-propyl) phosphate (BDCPP) were negatively associated with testosterone (T) (BCEP: β = -0.06 [-0.10, -0.01]; BDCPP: β = -0.07 [-0.13, -0.01]) and free androgen index (FAI) (BCEP: β = -0.08 [-0.13, -0.02]; BDCPP: β = -0.06 [-0.12, -0.01]). Diphenyl phosphate (DPHP) was also negatively associated with FAI (β = -0.08 [-0.14, -0.02]). RCS analyses revealed non-linear exposure-response relationships between DPHP and T, between BDCPP and estrogen (E2), and between BDCPP and DPHP and the T/E2 ratio. PCA and qgcomp analyses consistently found negative associations between the OPEs mixture and T and FAI. Conversely, in premenopausal women, BCEP was linearly and positively associated with sex hormone-binding globulin (SHBG) (β = 0.05 [0.01,0.09]), whereas DPHP showed a nonlinear relationship with SHBG, with a curve rising then plateauing. Overall, OPEs, alone or as mixtures, might lower T and FAI levels in postmenopausal women. In contrast, BCEP and DPHP might increase SHBG levels in premenopausal women. - Source: PubMed
Publication date: 2026/09/05
Zheng YabingFang Lanlan