Ask about this productRelated genes to: IL1b antibody
- Gene:
- IL1B NIH gene
- Name:
- interleukin 1 beta
- Previous symbol:
- -
- Synonyms:
- IL1F2, IL-1B, IL1-BETA
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-03-31
- Date modifiied:
- 2016-10-05
Related products to: IL1b antibody
Related articles to: IL1b antibody
- The objectives of this study were to evaluate the effects of dietary PB6 supplementation on inflammatory mediators in milk during an intramammary LPS challenge in dairy cows. A secondary objective was to determine if repeated LPS challenges induced the development of innate immune memory and immunological tolerance. Mid-lactation Holstein cows (n = 20; 147 ± 48 DIM; 2.2 ± 0.93 parity; 42.1 ± 7.6 kg/d of milk; mean ± SD) were enrolled in a crossover design. Treatments included PB6 (BSP) or limestone (control; CON) at 13 g/d, which were top-dressed daily onto a basal lactating TMR for 28-d periods. An intramammary LPS challenge (10 µg, O111:B4) was conducted in a rear quarter on d 24 of each period. Milk samples were collected at 0, 3, 12, and 24 h relative to the intramammary LPS challenge from the challenged quarter to measure SCC and cytokines. For cytokines, milk samples were treated with rennet and centrifuged to obtain whey, and 13 cytokines/chemokines were measured using a multiplex assay (IFNF, IL1A, IL1B, IL4, IL6, IL10, IL17A, IL36RN, CXCL10, CCL2, CCL3, TNF, and VEGFA). Linear mixed models included the fixed effects of treatment, period, and time, and their interactions, and the random effects of cow nested within period, block, and block by period. Dietary BSP supplementation increased SCS at 3 h but decreased SCS at 12 h during period 1 as compared with CON; we found were no treatment effects on SCS during period 2. Dietary BSP increased whey CCL2 (monocyte chemokine) at 3, 12, and 24 h relative to the LPS challenge during period 1; however, during period 2, dietary BSP decreased whey CCL2 at 3 and 12 h as compared with CON. These data suggest that dietary BSP supplementation may have enhanced innate immune training during period 1, and these effects carried over into the CON cows during period 2. Independent of treatment sequence, period 1 had greater concentrations of whey IL1A and IL1B at 3 h following the LPS challenge as compared with period 2, suggesting the development of endotoxin tolerance. In conclusion, our data suggest that dietary BSP supplementation may alter whey CCL2 concentrations, which may have influenced immune cell trafficking to the mammary gland during an intramammary LPS challenge. Period effects point to the development of endotoxin tolerance in cows receiving 2 intramammary LPS challenges. - Source: PubMed
Publication date: 2026/02/19
Swartz T HReyes OReisinger H LSarmiento A CeleminLarsen M BulnesMamedova L KBrown-Crowder I EHergenreder J EBradford B J - Inflammatory mediators within the tumor microenvironment contribute to lung cancer progression by enhancing cellular motility and invasive capacity through cytokine-dependent signaling networks. Modulation of these inflammation-associated pathways by dietary bioactive compounds may provide complementary strategies for limiting cancer aggressiveness. Our objective was to examine the inhibitory effects of a cyanidin-3-O-glucoside (C3G)-rich fraction from Kum Akha pigmented black rice (CKAB-P1) on inflammation-stimulated A549 cancer cell progression. - Source: PubMed
Publication date: 2026/04/10
Semmarath WarathitArjsri PunnidaSrisawad KamonwanIntanil IntraneeJamjod SansaneeProm-U-Thai ChanakanDejkriengkraikul Pornngarm - Improving rabbit welfare through alternative housing systems requires a better understanding of how environmental conditions modulate physiological and immune responses at the molecular level. This study aimed to evaluate the influence of different rearing systems on the expression of genes associated with inflammation, immune regulation, and stress response in Termond White rabbits. - Source: PubMed
Publication date: 2026/04/13
Siudak ZuzannaBielański PawełRopka-Molik KatarzynaPiórkowska KatarzynaKowalska Dorota - A549 cells are widely used as an in vitro model of alveolar type II (ATII) epithelial cells; however, their phenotype and metabolic state are highly sensitive to culture conditions, cell density, and the duration of static, non-passaged cultivation. Here, we examined how prolonged static culture affects lipid metabolism, mitochondrial bioenergetics, and viability in A549 cells. A549 cultures were maintained without passaging for up to 25 days in DMEM or Ham's F-12 and analyzed using lipid secretion assays, targeted lipidomics, [C]-acetate incorporation, Seahorse bioenergetic profiling, and transcriptional analysis of stress-associated markers. Several surfactant-associated readouts were highest during early culture, peaking on day 7, as evidenced by elevated expression of and SP-A and maximal secretion of surfactant-associated phospholipids. With prolonged cultivation and increasing culture density, cellular phosphatidylglycerol levels declined progressively and became nearly undetectable by day 25, accompanied by reduced anabolic lipid metabolism, lower oxygen consumption, and impaired glycolytic activity. These changes coincided with increased reactive oxygen species, elevated intracellular Ca levels, and increased expression of stress-associated transcripts, including , , and . Later stages were also associated with reduced mitochondrial respiration and decreased viability. Collectively, our findings show that prolonged static culture is associated with metabolic remodeling and reduced bioenergetic capacity in A549 cells. - Source: PubMed
Publication date: 2026/04/10
Ďurišová IvanaŠofranková LuciaKvasnička AlešBaláž MiroslavFábryová IvanaFriedecký DavidBalážová Mária - Interleukin-10 (IL-10) is a key immunoregulatory cytokine that suppresses inflammatory gene transcription in myeloid cells through signal transducer and activator of transcription 3 (STAT3). In Alzheimer's disease and neuroinflammation, microglia express and exhibit STAT3 Tyr705 phosphorylation following IL-10 stimulation, indicating IL-10 receptor-dependent STAT3 activation. Recent studies demonstrate that IL-10 induces promoter-selective STAT3-dependent transcriptional regulation in microglia through chromatin-associated mechanisms, whereas gp130-dependent cytokines activate STAT3 to induce transcription of defined target genes, including and . Following IL-10 receptor activation, STAT3 binds regulatory regions of inflammatory genes, including , and , with reduced RNA polymerase II and NF-κB binding. IL-10-dependent transcriptional repression involves formation of a nuclear SHIP1-STAT3 complex, localization of histone deacetylase (HDAC)1 and HDAC2 to H3K4me1-enriched enhancer regions, reduced H3K27ac, and decreased chromatin accessibility at regulatory regions of inflammatory genes. IL-10-activated STAT3 induces , which regulates JAK1 and TYK2 activity and STAT3 phosphorylation. Impairment of IL-10 receptor signaling in microglia is associated with increased inflammatory gene expression, enhanced inflammasome-related transcription, demyelination, and amyloid accumulation. This review focuses on IL-10-STAT3-dependent transcriptional regulation in microglia, including receptor signaling, chromatin-associated mechanisms, and disease-associated gene expression in Alzheimer's disease and neuroinflammation. - Source: PubMed
Publication date: 2026/04/05
Kim Mi EunLee Jun Sik