Ask about this productRelated genes to: IL1b antibody
- Gene:
- IL1B NIH gene
- Name:
- interleukin 1 beta
- Previous symbol:
- -
- Synonyms:
- IL1F2, IL-1B, IL1-BETA
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-03-31
- Date modifiied:
- 2016-10-05
Related products to: IL1b antibody
Related articles to: IL1b antibody
- Bisphenol S (BPS), a widely used substitute for Bisphenol A (BPA), is frequently detected in aquatic environments and has raised concerns due to its potential neurotoxic effects. Despite being marketed as a safer alternative, the long-term impacts of BPS on neural function and behaviour remain poorly understood. This study investigated whether embryonic exposure to environmentally relevant concentrations of BPS induces persistent neurobehavioural, neurochemical, and molecular alterations in adult zebrafish (Danio rerio). Embryos were exposed to an environmentally relevant concentration of BPS (30 µg/L) from 4 to 120 h post-fertilization (hpf) and subsequently reared in clean water until 6 months of age. Adult behavioural assessments revealed that BPS-exposed fish exhibited significant deficits in social affiliation, spending less time in the conspecific zone during group preference testing. However, shoaling behaviour and anxiety-like responses in the novel tank test, including swimming speed and zone preference, remained unaffected. Neurochemical analysis showed a significant reduction in brain dopamine levels, while serotonin (5-HT) and acetylcholine (ACh) levels were unchanged. Oxidative damage was corroborated by a significant elevation of brain lipid peroxidation (LPO) following embryonic BPS exposure. Molecular profiling of adult brain tissues revealed alterations in genes associated with oxidative stress (gpx1a), apoptosis (p53, bax, casp3), neuroinflammation (tnf-α, il1b, ngfb), and neurotransmission, particularly within serotonergic (slc6a4b, htr1d, htr2b) and cholinergic (chata) pathways. These findings indicate that embryonic BPS exposure leads to persistent neurochemical and transcriptional changes that selectively impair adult social behaviour without broadly affecting anxiety or locomotion. These observations underscore the potential neurodevelopmental toxicity of BPS and the urgent need to re-evaluate its safety in aquatic environments. - Source: PubMed
Publication date: 2026/05/05
Hasan A K M MunzurulRachamalla MaheshChivers Douglas PNiyogi Som - This study was conducted to delineate layer-specific transcriptomic alterations in the keratoconus (KC) epithelium and stroma and to identify potential biomarkers using machine learning (ML)-based analysis. - Source: PubMed
Publication date: 2026/05/08
Du KaiyuePeng RongmeiXiao GegeQu YiHan LiangHong Jing - Inflammatory cytokines, particularly interleukin-1β (IL-1β), have a main role in diabetic nephropathy (DN) pathogenesis. Genetic variations within the IL1B promoter region may modulate cytokine expression and affect vulnerability to renal injury in type 2 diabetes mellitus (T2DM). We aimed to assess the correlation between the IL1B (-511C/T;rs16944) polymorphism, IL-1β serum levels, and renal function among Egyptian cases with T2DM. - Source: PubMed
Publication date: 2026/05/07
Zaki Maysaa El SayedSalem Eman Hosney MohammedElbaz Amro Abdel-HamidEssa Sara Ghaleb - Reliable molecular biomarkers for poststroke cognitive impairment (PSCI) remain limited. Using publicly available bulk transcriptomic and single-cell RNA-seq datasets from GEO, we investigated lactate metabolism- and pyroptosis-related signatures and developed a diagnostic model. Differential expression analysis, KEGG pathway enrichment, and weighted gene coexpression network analysis (WGCNA) were performed, followed by multialgorithm feature selection (LASSO, SVM-RFE, and random forest). A logistic regression classifier was trained in the discovery cohort and externally validated in an independent cohort. Glycolysis/lactate metabolism, HIF-1 signaling, and NOD-like receptor-related pathways were enriched in PSCI-associated samples, and key coexpression modules were strongly correlated with ischemic injury traits. Cross-model consensus identified LDHA, GSDMD, and CASP1 as hub genes, yielding an AUC of 0.912 (95% bootstrap CI: 0.841-0.983) in the training cohort and 0.885 (95% bootstrap CI: 0.798-0.972) in the validation cohort. Immune deconvolution and scRNA-seq validation suggested increased proinflammatory microglia-associated signals, with relatively higher LDHA expression in microglia than in neurons; cell-cell communication analysis highlighted inflammatory interactions including IL1B-IL1R1. Connectivity map (CMap) analysis nominated candidate compounds, and molecular docking predicted favorable binding between oxamate and LDHA (binding energy = -9.5 kcal/mol). Collectively, these findings propose a compact LDHA/GSDMD/CASP1 biomarker panel for PSCI diagnosis and provide hypothesis-generating therapeutic leads that warrant further experimental validation. - Source: PubMed
Publication date: 2026/05/06
Ge ShulongZhang QiyingLiu NingZheng XueyanXu HanZhang Li - » There is a poor understanding of the significance of biomarkers in the blood, synovial fluid, and tissue in patients with shoulder instability and posttraumatic osteoarthritis (PTOA). » Identification of biomarkers associated with injury severity in shoulder instability may provide prognostic information to help guide surgical treatment algorithms. » Current evidence suggests that the biomarkers of periostin, tumor necrosis factor-alpha, IL1B, and cartilage oligomeric matrix protein are associated with injury severity in patients with recurrent anterior shoulder instability. » There is limited information on genetic, transcriptomic, and protein biomarkers which may indicate individuals who are at more risk for development of shoulder instability. » An improved understanding of the local biomolecular tissue response to first-time and recurrent anterior shoulder instability may contribute to the development of novel therapeutic strategies for gene and protein targets to halt the early cascade of PTOA. - Source: PubMed
Publication date: 2026/05/12
Rooney Patrick WCorken ReillyWishman Mark DCall CoryBozoghlian MariaLane CarterColeman Mitchell CNepola James VPatterson Brendan MGalvin Joseph W