Ask about this productRelated genes to: ApoB antibody
- Gene:
- APOB NIH gene
- Name:
- apolipoprotein B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: ApoB antibody
Related articles to: ApoB antibody
- High plasma cholesterol levels substantially contribute to cardiovascular disease. Hepatic delivery of the microRNA-30c analog C2 decreased plasma cholesterol in apoB-containing lipoproteins in hypercholesterolemic C57BL/6 mice, in African green monkeys that spontaneously developed diabetes and hyperlipidemia and prevented diet-induced hypercholesterolemia in mice with humanized livers. Furthermore, C2 significantly reduced plasma cholesterol and atherosclerosis in LDL receptor knockout mice. C2 did not affect hepatic triglyceride and cholesterol, plasma ALT, AST, CK-MB, ALP, IL-6, TNF-α, and INF-ϒ, thus indicating an absence of tissue lipid accumulation and inflammatory response. In contrast, MTP inhibitor lomitapide significantly reduced plasma lipids and caused hepatic steatosis. Mechanistic studies revealed that C2 reduced hepatic microsomal triglyceride transfer protein expression, secretion of apolipoprotein B-containing lipoproteins and FA synthesis and increased hepatic FA oxidation, plasma bile acids and fecal cholesterol excretion. C2 is a first-in-class microRNA therapeutic that decreases plasma cholesterol and atherosclerosis, without causing hepatic injury and inflammatory response. - Source: PubMed
Publication date: 2026/04/24
Prakash BinuChang ZhihuaRajan SujithScarberry Shannon RGangula BhargaviHossain Md MusaPrakashmurthy ChandanaValmiki SwatiPulatov OtabekYadav Pradeep KumarCarsons Steven ETemel Ryan EKavanagh KylieSheng JiaHussain M Mahmood - Women with type 1 diabetes (T1D) experience a greater diabetes-related increase in cardiovascular disease (CVD) and mortality risk than men. This study aimed to examine early sex-related differences in CVD risk factors among youth with T1D. - Source: PubMed
Publication date: 2026/04/21
Schweiger Darja ŠmigocMlinarič ZalaMacedoni MaddalenaGiani ElisaPlesnik EmilHovnik TinkaKotnik PrimožDovč KlemenBratina NatašaBattelino TadejGrošelj Urh - - Source: PubMed
Publication date: 2026/04/22
Essalmani RachidEvagelidis AlexandraRoubtsova AnnaChong MichaelPathan NaziaPare GuillaumePetrochenko Evgeniy VReimund MartRemaley Alan TChalifour LorraineSchweitzer MorrisSeidah Nabil G - - Source: PubMed
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Ueki YasushiLosdat SylvainKoskinas Konstantinos CRäber Lorenz - - Source: PubMed
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