Ask about this productRelated genes to: MMP7 antibody
- Gene:
- MMP7 NIH gene
- Name:
- matrix metallopeptidase 7
- Previous symbol:
- MPSL1
- Synonyms:
- PUMP-1
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-15
- Date modifiied:
- 2015-08-25
Related products to: MMP7 antibody
Related articles to: MMP7 antibody
- Differentiating between malignant and benign biliary strictures remains a clinical challenge because current diagnostic tools have limited sensitivity. The detection of tumour-related biomarkers directly in bile, which is in close contact with the lesion, may enhance diagnostic accuracy. This study aimed at evaluating the diagnostic and prognostic values of biliary concentrations of VEGF, PDGF-AA, IGF and MMPs in patients with extrahepatic cholangiocarcinoma (CCA), pancreatic ductal adenocarcinoma (PDAC), or benign obstruction. - Source: PubMed
Gigante EUntereiner VCaruso SRhaiem RGrados LBoulagnon-Rombi CAdam SSockalingum G DGarnotel RThiefin G - ASPSCR1::TFE3 renal cell carcinoma (RCC) is a distinct subtype of renal cell carcinoma characterized by a high rate of lymph node metastasis and poor prognosis. Its unclear pathogenesis and immune microenvironment have hindered clinical treatment. This study analyzed FFPE samples of ASPSCR1::TFE3 RCC and clear cell renal cell carcinoma (ccRCC) using single-cell sequencing and high-resolution spatial transcriptomics.The results showed significant differences in tumor and immune microenvironment between ASPSCR1::TFE3 RCC and ccRCC: ccRCC was enriched in pathways such as interferon response and hypoxia, while ASPSCR1::TFE3 RCC was involved in processes including oxidative phosphorylation and epithelial-mesenchymal transition. Tumor cells of ASPSCR1::TFE3 RCC could be divided into C3/C4 subtypes; among them, the C3 subtype, which is mainly involved in cell metastasis, showed significantly higher expression of pro-invasive genes such as MDK, MMP7, and VCAN. In terms of the immune microenvironment, ASPSCR1::TFE3 RCC exhibited an immunosuppressive phenotype, manifested by an increase in macrophages and exhausted T/NK cells. Moreover, the interaction between tumor cells and macrophages mediated by MDK-LRP1 led to its immune escape.This study confirms that ASPSCR1::TFE3 RCC is a malignant tumor with immunosuppressive features and high metastatic potential, characterized by the enrichment of the C3 subgroup and elevated MDK expression. It provides new insights for the clinical targeted therapy of ASPSCR1::TFE3 RCC and is expected to expand the population of beneficiaries of immunotherapy. - Source: PubMed
Publication date: 2026/04/18
Wang YingjingWu XiaCheng XiaoFang RongZhang PingWang HeliYu SenxiaoZhang HuizhiZhao Ming - Quantifying how biological and chemical exposures reshape spatial gene regulation across tissues remains challenging due to technical and statistical constraints. Moreover, spatial transcriptomic comparisons are often hindered by tissue misalignment between conditions and the pervasive zero inflation of single-cell gene expression data. Existing differential expression approaches typically ignore spatial dependencies and fail to capture differential gene activation. We present Spatial-ZEDNet, a hierarchical Gaussian random field framework that jointly detects spatially differentially expressed genes (DEGs) and differentially activated genes (DAGs) while explicitly modeling zero inflation. Unlike previous tools, Spatial-ZEDNet aligns biological signals across conditions without requiring spatial coordinate matching, improving spatial inference robustness. In both simulations and real biological applications, Spatial-ZEDNet demonstrates superior power and specificity relative to standard methods and is robust in distinguishing DEGs from spatially variable genes. Applied to colitis and Plasmodium infection datasets, the method identified spatially localized expression and activation of immune genes, including Mmp7, Olr1, Ifitm3, and Gbp3, several of which correspond to known inflammatory disease loci, highlighting coordinated tissue-specific responses often missed by conventional methods. These findings demonstrate that explicitly modeling excess zeros improves the detection of spatially regulated activation states. Spatial-ZEDNet provides a statistically rigorous, interpretable framework for integrating spatial transcriptomic data across environmental and therapeutic exposures, advancing mechanistic understanding of exposure-induced tissue remodeling. - Source: PubMed
Egbon Osafu AugustineAtitey KomlanLi JiaqiAnchang Benedict - Infected wound healing is delayed due to compromised immunity and antimicrobial resistance. Antibiotic resistance is an emerging threat due to the unnecessary use of antibiotics. Current wound dressings that promote chronic wound healing either require additional processes, such as photothermal irradiation, or leave behind large amounts of undesirable residues. Gramicidin D (GCN), a mixture of gramicidin A, B, and C derived from , is a linear antimicrobial peptide that has been shown to exhibit wound healing properties in recent studies. molecular docking simulations of GCN were conducted to preliminarily explore its potential interactions with proteins associated with the wound-healing process. The analysis suggested possible binding interactions with MMP3 and MMP7, indicating a hypothetical mechanism that may warrant further experimental validation, rather than establishing a direct role in the observed wound-healing effects. Therefore, in this study, we report a dual-functionality chitosan (CS) hydrogel dressing enriched with GCN and a multifunctional, non-reducing carbohydrate moiety called trehalose (TH) for combating antimicrobial resistance and accelerating infected wound healing. The GCN- and TH-enriched hydrogel matrix was successfully developed using an ionic-crosslinking method and optimised with the Box-Behnken Design (BBD) approach using Design Expert Software. The developed hydrogel formulation demonstrated controlled GCN release, suitable physicochemical properties, and excellent antibacterial and antibiofilm potential. Moreover, the cell line data on HaCaT cells indicated suitable biocompatibility, non-toxic behaviour and enhanced cell migration. Additionally, an chronic infectious wound healing study confirmed that the GCN and TH dual-functional hydrogel promotes accelerated healing in rats. This approach represents a potential therapeutic strategy for the rapid healing of chronically infected wounds in a multifunctional manner. - Source: PubMed
Publication date: 2026/04/17
Kanaujia Kunal AgamArya Dilip KumarKumar AnitKanaujiya ShubhamPandey PrashantGanjipete SrinivasSaraf Shubhini APavadai ParasuramRajinikanth P S - Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of interstitial lung disease (ILD). However, the causal role of MMPs in ILD pathogenesis remains to be elucidated. This study aimed to investigate the causal effects of circulating MMPs on ILD risk and to evaluate whether immune cell phenotypes mediate this relationship. A comprehensive Mendelian randomization (MR) and mediation analysis was conducted using publicly available data of genome-wide association study (GWAS) summary statistics. Genetic instruments for 6 MMPs (MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-12) and 731 immune cell traits were selected. Inverse-variance weighted (IVW) was the primary analytical method, supplemented by other MR techniques. Sensitivity analyses included MR-Egger regression, Cochran Q test, and MR-PRESSO to assess pleiotropy and heterogeneity. Mediation analysis was performed to quantify the proportion of the effect mediated by significant immune cells. Genetically predicted MMP-9 levels showed a significant positive causal effect on ILD risk (odds ratio [OR] = 1.034, 95% confidence interval [CI]: 1.006-1.064, P = .018). Among 731 immune cell phenotypes, 8 were identified as causal for ILD, including effector memory double negative T cells (EM DNT; OR = 1.170, P = .001). MMP-9 was further found to increase the abundance of EM DNT (OR = 1.041, 95% CI: 1.009-1.074, P = .012). Mediation analysis indicated that EM DNT mediated 18.5% of the total effect of MMP-9 on ILD. Sensitivity analyses revealed no evidence of horizontal pleiotropy or significant heterogeneity. This study provides genetic evidence supporting a causal role of MMP-9 in the development of ILD, partially mediated through EM DNT. These findings suggest that MMP-9 and EM DNT could be potential therapeutic targets for preventing or treating ILD. - Source: PubMed
Ren QijieSun FengyuanYang LeileiSu DingleiShen Minning