Ask about this productRelated genes to: CD154 antibody
- Gene:
- CD40LG NIH gene
- Name:
- CD40 ligand
- Previous symbol:
- HIGM1, IMD3, TNFSF5
- Synonyms:
- CD40L, TRAP, gp39, hCD40L, CD154
- Chromosome:
- Xq26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD154 antibody
Related articles to: CD154 antibody
- Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic mutations, where chronic inflammation drives disabling complications affecting quality of life and survival. Effective inflammatory control remains a major unmet need. While systemic administration of mesenchymal stromal cells (MSC) from various sources has proven safe with transient benefits yet only one recent placebo-controlled study in RDEB. Consistent type VII collagen (C7) deposition is lacking, and therapeutic mechanisms and predictive biomarkers remain undefined. The MesenSistem-EB trial evaluated for the first time the use of haploidentical BM-MSC and extensively explored their anti-inflammatory potential as a monotherapy in RDEB. - Source: PubMed
Publication date: 2026/05/05
Maseda RocíoArriba María CarmenMartínez-Santamaría LucíaJiménez EvaHerráiz-Gil SaraIllera NuriaQuintana-Castanedo LucíaGarcía MartaSuárez-Sancho SusanaYáñez RosaPérez-Conde IsabelCarretero MartaMartínez-Queipo Magdalenade Paz RaquelLeón CarlosJiménez-Yuste VíctorBorobia Alberto MVicente ÁngelesLwin Su MMcGrath John AFernández-Santos María EugeniaButta NoraSacedón RosaDel Río Marcelade Lucas RaúlEscámez María José - Bacillus Calmette-Guérin (BCG) vaccination exerts non-specific immunomodulatory effects through trained immunity, potentially modulating inflammatory responses in COVID-19. Tumor necrosis factor-alpha (TNF-α) and soluble CD40 ligand (sCD40L) are key inflammatory and pro-thrombotic mediators implicated in COVID-19 pathogenesis. - Source: PubMed
Publication date: 2026/05/13
Fávero CarolineBarbosa GabrielaPellegrini VanessaMelo DayaneShariat Shahrokh FPascoal Lívia BitencourtReis Leonardo O - Nucleolar protein 16 (NOP16) has been increasingly implicated in promoting tumorigenesis and was recently identified as a novel epigenetic regulator. However, its physiological role in nonmalignant cells remains poorly understood. Although NOP16 is ubiquitously expressed across various tissues and cell types, we found it to be preferentially upregulated in activated B cells, whereas its level in light zone germinal center (GC) B cells within human tonsils and vaccinated mice-derived spleen were higher than in dark zone levels. In 2 independent murine B cell lines, stimulation with TGF-β, IL-4, and CD40 ligand, to induce class switch recombination (CSR) from IgM to IgA, led to a downregulation of NOP16 and a concomitant upregulation of activation-induced cytidine deaminase (AID). We found that TGF-β mediates the downregulation of NOP16. Moreover, RNA-seq analysis revealed that knockdown of NOP16 markedly increased AID expression in B cells. Interestingly, knockdown of NOP16 enhanced class switching to IgA by upregulating AID induction in both murine B cell lines. NOP16 knockdown did not affect class switching to IgG2b or IgG3, suggesting isotype-specific regulation. These findings identify NOP16 as a previously unrecognized modulator of CSR, highlighting its physiological relevance in adaptive immunity and extending its functional significance beyond cancer biology. - Source: PubMed
Mtali Yohana SilasTakashima KenGreer Eric LiebermanOshiumi Hiroyuki - Megakaryopoiesis is an elaborate biological process that primarily occurs in the bone marrow. To gain deeper insights into molecular mechanisms driving normal megakaryopoiesis, we utilized an in vitro human megakaryocytic culture system based on mobilized peripheral blood-derived CD34 cells. Following fluorescence-activated cell sorting (FACS) isolation of CD41 and CD41 megakaryocyte (MK) subsets, mature MKs were confirmed through characterization of MK-specific surface markers, ploidy analysis, Giemsa staining, and immunofluorescence. Subsequent bulk RNA sequencing of these distinct populations enabled the identification of differentially expressed genes (DEGs) and enriched pathways. Based on our CD34-derived MK differentiation model, the expression of CD41 was found robustly induced by day 4 and further elevated by day 10. The CD41 population exhibited marked co-expression of CD42b and CD61, a significantly higher proportion of polyploid cells (≥16 N), along with characteristic morphological features of mature MKs, including proplatelet formation, cytoplasmic maturation, and cell size enlargement compared to the CD41 subset. Transcriptomic profiling of these two populations identified 1877 up-regulated and 1817 down-regulated DEGs in CD41 MKs. Protein-protein interaction (PPI) network analysis of the key DEGs revealed hub genes including VWF, PF4V1, SELP, PF4, GP1BA, CD40LG, PPBP, CLEC1B, P2RY12, and THBS1. Functional enrichment underscored the acquisition of migratory, adhesive, and secretory capacities, marked by significant upregulation of platelet activation and wound healing signatures. Pathway analysis further indicated coordinated activation of focal adhesion, cytoskeletal reorganization, glycerolipid metabolism, and neuroactive ligand-receptor interaction during maturation. This study provides an integrative transcriptomic blueprint of human MK maturation and highlights the novel candidate targets for thrombopoiesis. - Source: PubMed
Publication date: 2026/05/15
Zhang ZiyanWang YueLiu Peng - Diabetic retinopathy is one of the most important complications of diabetes. It is a leading cause of visual loss in the world. While adequate control of hyperglycemia, hypertension and hyperlipidemia can decrease the prevalence of diabetic retinopathy, 60% of patients with type 2 diabetes develop this complication whereas it is estimated that most patients with type 1 diabetes will develop diabetic retinopathy. Upregulation of various pro-inflammatory molecules and vascular endothelial growth factor (VEGF) play a central role in the pathogenesis of the disease. Here we review the role of CD40 as an upstream inducer of these abnormalities and the development of diabetic retinopathy. - Source: PubMed
Publication date: 2026/04/27
Subauste Carlos S