Ask about this productRelated genes to: Sox2 antibody
- Gene:
- SOX2 NIH gene
- Name:
- SRY-box 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q26.33
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-30
- Date modifiied:
- 2019-04-23
Related products to: Sox2 antibody
Related articles to: Sox2 antibody
- The development of effective evaluation tools for anti-hair loss therapies is critical due to limitations in existing experimental systems. Hairy 3D skin models and hairy skin explants are not yet commercially viable, necessitating alternative approaches for assessing androgenic alopecia (AGA). - Source: PubMed
Publication date: 2026/04/12
Kyung SeoyeonLim Su JinLee Kyung EunNho Youn-HwaLee Bo EunWulansari NovianaYoo JongmanKim Soon RePark Byung CheolYon Dong KeonKang Seunghyun - Increased Src kinase activity is known to correlate with cancer progression and poor prognosis, indicating that Src plays a central role in cell migration and invasion. In this study, we investigated the effects of saracatinib, a Src kinase inhibitor, under anoikis-resistant conditions in colorectal cancer cells. - Source: PubMed
Publication date: 2026/04/22
Yoon ChanwoongNa EuihyeonChoi Min JooYoon Sang-Pil - Acute monocytic leukaemia (AML-M5) disease models are scarce. To address this, we reprogrammed THP-1 cells from a patient into AML-M5-specific induced pluripotent stem cells (AML-M5-iPSCs) and differentiated them into monocytic-like cells. Unexpectedly, reprogramming transgenes Oct3/4, Sox2 and c-Myc were reactivated in the AML-M5-iPSC genome. This study examined how transgene reactivation influences responses to doxorubicin in differentiated monocytic-like cells; MATERIALS AND METHODS: AML-M5-iPSCs were differentiated into monocytic-like cells using hM-CSF and IL-3. Cell morphology, phagocytotic activity and surface markers expression of monocytic-like and THP-1 cells were assessed and compared. Cytotoxicity and apoptotic effects of doxorubicin were investigated with CCK-SK assay and flow cytometry; RESULTS: Monocytic-like cells showed morphology, size, and phagocytosis comparable to THP-1 cells. However, they expressed lower surface markers CD4, CD117, CD33, CD64 and HLA-DR than THP-1 cells. Following 24h doxorubicin exposure, THP-1 cells exhibited an IC of 0.59 μM, while the IC for monocytic-like cells could not be determined. Upon similar treatment conditions, 92.47±3.90% of THP-1 cells underwent late apoptosis. In contrast, only 0.26±0.21% of monocytic-like cells entered late apoptosis, 37.23±1.52% underwent necrosis and 62.47±1.63% remained viable; CONCLUSION: Reactivation of Oct3/4, Sox2 and c-Myc in AML-M5-iPSCs induced lower surface marker expression and doxorubicin resistance in monocytic-like cells. Moreover, the apoptotic effect of doxorubicin had been switched to necrotic effect. Surprisingly, morphology and phagocytic function were unaffected. We postulate that transgene reactivation disrupts epigenetic stability and downstream apoptotic pathways. Further investigations are warranted to clarify mechanisms underlying transgene-mediated drug resistance in iPSC-derived disease models. - Source: PubMed
Kim K LLeong P PCheong S KSaik A Y H - An induced pluripotent stem cell (iPSC) line was successfully generated from dermal fibroblasts of a patient with Duchenne muscular dystrophy (DMD) harboring the pathogenic nonsense variant c.1286C>G (p.Ser429Ter) in the DMD gene using non-integrating Sendai virus reprogramming. The iPSC clone exhibited typical pluripotent stem cell morphology, expressed key pluripotency markers (OCT4, SSEA4, NANOG, and TRA-1-60), and retained trilineage differentiation potential. The cell line had a normal karyotype, and elimination of reprogramming vectors (OCT3/4, SOX2, KLF4, and c-MYC) was confirmed. This isogenic cell model provides a valuable platform for investigating DMD pathogenesis associated with this specific mutation and for developing targeted therapeutic approaches, including CRISPR/Cas9-mediated gene correction. - Source: PubMed
Publication date: 2026/04/29
Panchuk I OGrigorieva O VKurshakova E VNagieva S EShchagina O ALevchenko O APozhitnova V OVoronina E STabakov V YuSmirnikhina S ALavrov A V - To study the effect of low-estrogen and the menopause state upon female pituitary function, we used the 4-vinylcyclohexene diepoxide (VCD)-induced ovarian failure model to gradually reduce serum estradiol (E2) levels. We utilized single-cell RNA sequencing transcriptomics analysis (scRNA-seq) to determine how reduced E2 levels influence pituitary gonadotrope gene expression and cell state, with a focus on potential contributions from pituitary stem cells to gonadotrope population growth. VCD-treated mice were acyclic and exhibited 8-15-fold increases in serum levels of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Serum E2 levels were half those of normally cycling proestrous females. Pituitary scRNA-seq identified two gonadotrope populations based upon distinct gene expression signatures (a higher cell number primary cluster, designated here as GON1 and a smaller cell number secondary cluster, designated GON2). The GON1 population increased in number significantly in low-E2, VCD-treated mice, expressing markers indicative of contributions from pituitary stem cell activation. Both gonadotrope populations showed upregulated genes for canonical pathways supporting mRNA translation and hormone secretion, which correlated well with the high serum gonadotropin levels. Consistent with the high serum gonadotropin levels, Fshb and Lhb mRNAs were increased in whole pituitary samples (RT-qPCR). The pituitary Sox2-positive stem cell population exhibited increased expression of more mature transitional progenitors, including Sox9 mRNA, and showed upregulation of pathways involved in stem cell development and mitotic activity. This model provides insight into the cellular and molecular adaptations of the pituitary to the low-E2, menopausal state, with potential relevance for understanding human perimenopausal and menopausal physiology. - Source: PubMed
Publication date: 2026/04/29
Odle Angela KMiles Tiffany KHerdman Ashley KClark Lillian GByrum Stephanie DLagasse Alex NHaney Anessa CMacNicol Angus MChilds Gwen VMacNicol Melanie C