Ask about this productRelated genes to: GATA1 antibody
- Gene:
- GATA1 NIH gene
- Name:
- GATA binding protein 1
- Previous symbol:
- GF1
- Synonyms:
- ERYF1, NFE1, GATA-1, NF-E1
- Chromosome:
- Xp11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2019-04-23
Related products to: GATA1 antibody
Related articles to: GATA1 antibody
- The GATA family of zinc finger DNA-binding transcription factors plays a crucial role in regulating genes responsible for embryogenesis, cellular differentiation, and normal physiological development. This family comprises six members, designated as GATA1 to GATA6, with GATA4 being of particular significance due to its prominent tissue-specific functions. Mutations in GATA4 have been extensively linked with human congenital diseases affecting the heart, lungs, and reproductive system. It is regulated by post-translational modifications, notably phosphorylation at serine 105 by ERK and p38MAPK kinases. The expression and oncogenic/tumor-suppressive roles of GATA4 in cancer have sparked substantial research interest. GATA4 forms essential regulatory complexes with its family members, GATA5 and GATA6 during early myocardial development, and with transcriptional cofactors such as TBX5 and NKx2-5, underscoring its importance in maintaining cellular and molecular homeostasis. Emerging evidence highlights that dysregulated GATA4 expression contributes not only to developmental abnormalities but also to cancer progression, where it may exhibit oncogenic or tumor-suppressive functions depending on the tissue context. These dual roles highlight GATA4 as a crucial molecular node in pathways governing cell survival, proliferation, and tumorigenesis. Therefore, understanding the multifaceted biological implications of GATA4 is indispensable for identifying novel therapeutic targets. This review aims to comprehensively summarize the functional significance of GATA4 in the pathophysiology of developmental disorders and diverse cancers. - Source: PubMed
Publication date: 2026/05/07
Dharshini Loganathan Chandramani PriyaRasmi Rajan RadhaSakthivel Kunnathur MurugesanMuniandi Balakumar - The pathogenesis of unexplained miscarriage (UM) is largely unclear. Environmental Zn pollution is widely present in various environments and inevitably ingested by pregnant women, which has shown reproductive toxicity. Disulfidptosis is a newly identified programmed cell death caused by excessive disulfide stress. Notably, the association, causation, and underlying mechanisms among Zn exposure, disulfidptosis, and unexplained miscarriage are completely unknown. In this study, based on two UM case-control groups, four ZnCl-exposed mouse models, and a ZnCl-exposed trophoblast Swan 71 cell model, we obtain a consistent conclusion that excessive Zn exposure causes disulfidptosis and thus induces miscarriage by up-regulating the GATA1/METTL1/SLC7A11 axis. In the mechanism, Zn exposure up-regulates GATA1 expression levels, which promotes GATA1-mediated METTL1 and SLC7A11 transcription. Meanwhile, Zn exposure also promotes METTL1-mediated m7G modification on SLC7A11 mRNA and thus increases SLC7A11 mRNA stability. Ultimately, Zn exposure up-regulates SLC7A11 expression levels at both transcription and post-transcription levels and thus causes disulfidptosis. Knockdown of murine Slc7a11, Gata1, or Mettl1, or supplement with NADPH suppresses mouse placental disulfidptosis and alleviates mouse miscarriage. This study not only discovers pathogenesis and biological mechanisms of Zn exposure-induced unexplained miscarriage but also provides potential targets, uncovering new health risk effects of Zn exposure in the environment-health field. - Source: PubMed
Publication date: 2026/05/07
Huang WenxinSun YiWang YanxinYan HaijunYue XiaopingWu WeidongChen XueyuZhang JinfangLin YanbingLei QiongJi NanXing ShuaishuaiZeng LiqinKang QingzhengZhao DepengGuo GengZhang Huidong - Generation of megakaryocytes (MKs) from stem cells in vitro to produce platelets (PLTs) is an appealing approach for providing an alternative source of PLTs. Understanding the transcriptomic characteristics of MKs in vitro is crucial for providing a theoretical foundation for producing functional MKs more efficiently in the future. - Source: PubMed
Publication date: 2026/05/02
He YanminLiang YueHe JiShen YuWu ZhipanPei ShanshanZhu Faming - GATA1 and GATA2 are zinc-finger transcription factors essential for normal hematopoiesis. As genetic testing becomes more widely integrated into clinical practice, -related disorders are increasingly recognized, making it important for clinicians to understand their diagnosis and management. - Source: PubMed
Publication date: 2026/04/24
Karr MatthewPalmisiano NeilChen Xiaoyi - Postpartum depression (PPD) is a common and serious mental disorder after childbirth, imposing a heavy burden on mothers, infants, and families. Abnormalities in the tryptophan-kynurenine (TRP-KYN) metabolic pathway are considered to be involved in its pathogenesis, but the role of quinolinic acid phosphoribosyltransferase (QPRT), a key downstream enzyme in this pathway, remains unclear. This study aims to explore the association between PPD in women undergoing cesarean section and gene polymorphisms, as well as other risk factors for PPD. - Source: PubMed
Zhao ShanshanLin GuoxinLi ZiyuanPing AnqiWang SaiyingDuan Kaiming